Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

Characterization of a Novel Murine Model to Study Zika Virus

(2016) Shannan L. Rossi et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Guillain-Barré syndrome associated with the Zika virus outbreak in Brazil

(2016) Lucas Masiêro Araujo et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise

(2016) Jonathan J. Miner et al.   CELL

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

(2016) Nicholas J. Barrows et al.   Cell Host & Microbe

A Mouse Model of Zika Virus Pathogenesis

(2016) Helen M. Lazear et al.   Cell Host & Microbe

Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice

(2016) Kong-Yan Wu et al.   CELL RESEARCH

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

(2016) Hengli Tang et al.   Cell Stem Cell

Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice

(2016) Cui Li et al.   Cell Stem Cell

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

(2016) Tomasz J. Nowakowski et al.   Cell Stem Cell

Drug combination therapy increases successful drug repositioning

(2016) Wei Sun et al.   DRUG DISCOVERY TODAY

Rapid Spread of Zika Virus in The Americas - Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games

(2016) Eskild Petersen et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Zika virus and microcephaly: why is this situation a PHEIC?

(2016) David L Heymann et al.   LANCET

Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study

(2016) Van-Mai Cao-Lormeau et al.   LANCET

Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen?

(2016) Jean Michel Mansuy et al.   LANCET INFECTIOUS DISEASES

Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities

(2016) Rita W. Driggers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus Associated with Microcephaly

(2016) Jernej Mlakar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika Virus and Birth Defects — Reviewing the Evidence for Causality

(2016) Sonja A. Rasmussen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence of Sexual Transmission of Zika Virus

(2016) Eric D’Ortenzio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Zika virus was transmitted by sexual contact in Texas, health officials report

(2016) Michael McCarthy   BMJ-British Medical Journal

Zika virus was transmitted by sexual contact in Texas, health officials report

(2016) Michael McCarthy   BMJ-British Medical Journal

Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039

(2015) Mika Okamoto et al.   ANTIVIRAL RESEARCH

Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1

(2015) Roger Badia et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Biology of Zika Virus Infection in Human Skin Cells

(2015) Rodolphe Hamel et al.   JOURNAL OF VIROLOGY

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection

(2015) Shanshan He et al.   Science Translational Medicine

A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity

(2015) Lisa M. Johansen et al.   Science Translational Medicine

Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients

(2015) A Topol et al.   Translational Psychiatry

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

(2014) Makoto Yamamoto et al.   JOURNAL OF CLINICAL INVESTIGATION

The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

(2014) Fernando J. Barreyro et al.   LIVER INTERNATIONAL

Synaptic dysregulation in a human iPS cell model of mental disorders

(2014) Zhexing Wen et al.   NATURE

Chemical signatures and new drug targets for gametocytocidal drug development

(2014) Wei Sun et al.   Scientific Reports

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

(2014) Jennifer Kouznetsova et al.   Emerging Microbes & Infections

A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS

(2013) Yin M. Yang et al.   Cell Stem Cell

Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

(2013) Wei Sun et al.   PLoS One

Identification of Three Antiviral Inhibitors against Japanese Encephalitis Virus from Library of Pharmacologically Active Compounds 1280

(2013) Jin'e Fang et al.   PLoS One

Novel, Selective CDK9 Inhibitors for the Treatment of HIV Infection

(2012) G. Nemeth et al.   CURRENT MEDICINAL CHEMISTRY

Effect of Mimetic CDK9 Inhibitors on HIV-1-Activated Transcription

(2012) Rachel Van Duyne et al.   JOURNAL OF MOLECULAR BIOLOGY

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

(2012) Anjan Debnath et al.   NATURE MEDICINE

Niclosamide Is a Proton Carrier and Targets Acidic Endosomes with Broad Antiviral Effects

(2012) Andreas Jurgeit et al.   PLoS Pathogens

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

(2011) R. Huang et al.   Science Translational Medicine

Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production

(2011) F L Khanim et al.   Blood Cancer Journal

High-ThroughputGiardia lambliaViability Assay Using Bioluminescent ATP Content Measurements

(2010) Catherine Z. Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II

(2010) J. Zhang et al.   JOURNAL OF VIROLOGY