Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way

Hallmarks of neurodegenerative diseases

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Somatic genomic changes in single Alzheimer’s disease neurons

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Interplay of cGAS with micronuclei: regulation and diseases

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Effects of dietary restriction on genome stability are sex and feeding regimen dependent

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Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease

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Alzheimer disease

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Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations

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Loss of Y chromosome at the interface between aging and Alzheimer’s disease

(2021) Xihan Guo   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss of Y chromosome: An emerging next-generation biomarker for disease prediction and early detection?

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NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

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Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells

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Mosaic loss of human Y chromosome: what, how and why

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Understanding the birth of rupture-prone and irreparable micronuclei

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Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes

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DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains

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A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease

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Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases

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PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

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Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model

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γH2AX is increased in peripheral blood lymphocytes of Alzheimer’s disease patients in the South Australian Neurodegeneration, Nutrition and DNA Damage (SAND) study of aging

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The human microglial HMC3 cell line: where do we stand? A systematic literature review

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The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem

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Microglia in Alzheimer’s disease

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Genome instability in Alzheimer disease

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Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways

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Guanine-quadruplexes are increased in mild cognitive impairment and correlate with cognitive function and chromosomal DNA damage

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Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

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Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease

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Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels

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X chromosome aneuploidy in the Alzheimer’s disease brain

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Selective Cell Death of Hyperploid Neurons in Alzheimer’s Disease

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Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the Presenilin-1 Alzheimer's disease brain

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Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions

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Alzheimer Aβ Peptide Induces Chromosome Mis-Segregation and Aneuploidy, Including Trisomy 21: Requirement for Tau and APP

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Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease

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Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

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Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy

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