Mosaic loss of human Y chromosome: what, how and why

High Concentration of Sugars is Genotoxic in Folate Deficient Cells

(2019) Xihan Guo et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

(2019) Peter Ly et al.   NATURE GENETICS

Age-dependent DNA methylation patterns on the Y chromosome in elderly males

(2019) Jesper B. Lund et al.   AGING CELL

Male-Specific Long Noncoding RNA TTTY15 Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis via TBX4

(2019) I-Lu Lai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

iPSCs-derived nerve-like cells from familial Alzheimer’s disease PSEN 1 E280A reveal increased amyloid-beta levels and loss of the Y chromosome

(2019) Miguel Mendivil-Perez et al.   NEUROSCIENCE LETTERS

Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease

(2019) Joohyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer modeling meets human organoid technology

(2019) David Tuveson et al.   SCIENCE

Y chromosome loss is associated with age-related male patients with abdominal aortic aneurysms

(2019) Dianjun Tang et al.   Clinical Interventions in Aging

Somatic mosaicism of sex chromosomes in the blood and brain

(2019) Emma J. Graham et al.   BRAIN RESEARCH

Human chromosome‐specific aneuploidy is influenced by DNA ‐dependent centromeric features

(2019) Marie Dumont et al.   EMBO JOURNAL

Polycyclic aromatic hydrocarbons exposure and their joint effects with age, smoking, and TCL1A variants on mosaic loss of chromosome Y among coke-oven workers

(2019) Yuhang Liu et al.   ENVIRONMENTAL POLLUTION

Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

(2019) Marcus Danielsson et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Inhibition of Human Y Chromosome Gene, SRY, Promotes Naïve State of Human Pluripotent Stem Cells

(2019) Sara Taleahmad et al.   JOURNAL OF PROTEOME RESEARCH

Genetic predisposition to mosaic Y chromosome loss in blood

(2019) Deborah J. Thompson et al.   NATURE

GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

(2019) Chikashi Terao et al.   Nature Communications

Somatically Acquired Isodicentric Y and Mosaic Loss of Chromosome Y in a Boy with Hypospadias

(2018) Mami Miyado et al.   CYTOGENETIC AND GENOME RESEARCH

Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study

(2018) Jason Y.Y. Wong et al.   ENVIRONMENT INTERNATIONAL

Chromosomes trapped in micronuclei are liable to segregation errors

(2018) Mar Soto et al.   JOURNAL OF CELL SCIENCE

Differences in the Effects of EGCG on Chromosomal Stability and Cell Growth between Normal and Colon Cancer Cells

(2018) Juan Ni et al.   MOLECULES

OUP accepted manuscript

(2018)   MUTAGENESIS

Biphasic regulation of spindle assembly checkpoint by low and high concentrations of resveratrol leads to the opposite effect on chromosomal instability

(2018) Xihan Guo et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Linear assembly of a human centromere on the Y chromosome

(2018) Miten Jain et al.   NATURE BIOTECHNOLOGY

Sex differences in Alzheimer disease — the gateway to precision medicine

(2018) Maria Teresa Ferretti et al.   Nature Reviews Neurology

Loss of chromosome Y in blood, but not in brain, of suicide completers

(2018) Atsushi Kimura et al.   PLoS One

Genetics of the human Y chromosome and its association with male infertility

(2018) Stacy Colaco et al.   Reproductive Biology and Endocrinology

USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability

(2018) Agnieszka Skowyra et al.   Cell Reports

The Y Chromosome Regulates BMPR2 Expression via SRY: A Possible Reason ‘Why’ Fewer Males Develop PAH

(2018) Ling Yan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chromosome Missegregation and Aneuploidy Induction in Human Peripheral Blood Lymphocytes In vitro by Low Concentrations of Chlorpyrifos, Imidacloprid and α-Cypermethrin

(2018) Vedran Mužinić et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Y chromosome mosaicism is associated with age-related macular degeneration

(2018) Felix Grassmann et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Association of mosaic loss of chromosome Y with lung cancer risk and prognosis in a Chinese population

(2018) Na Qin et al.   Journal of Thoracic Oncology

Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

(2018) Po-Ru Loh et al.   NATURE

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

(2018) Angli Xue et al.   Nature Communications

Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank

(2018) Erikka Loftfield et al.   Scientific Reports

Mosaic Y loss is moderately associated with solid tumor risk

(2018) Erikka Loftfield et al.   CANCER RESEARCH

Geraniin Differentially Modulates Chromosome Stability of Colon Cancer and Noncancerous Cells by Oppositely Regulating their Spindle Assembly Checkpoint

(2018) Xihan Guo et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The Long Noncoding RNA TTTY15, Which Is Located on the Y Chromosome, Promotes Prostate Cancer Progression by Sponging let-7

(2018) Guang’an Xiao et al.   EUROPEAN UROLOGY

Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma

(2018) Robert Hollows et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem

(2018) Xihan Guo et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Mosaic loss of chromosome Y in leukocytes matters

(2018) Lars A. Forsberg et al.   NATURE GENETICS

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

The Y chromosome: a blueprint for men’s health?

(2017) Akhlaq A Maan et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Copy number variation arising from gene conversion on the human Y chromosome

(2017) Wentao Shi et al.   HUMAN GENETICS

Y chromosome palindromes and gene conversion

(2017) Beniamino Trombetta et al.   HUMAN GENETICS

Past successes and future opportunities for the genetics of the human Y chromosome

(2017) Yali Xue et al.   HUMAN GENETICS

Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men

(2017) Lars A. Forsberg   HUMAN GENETICS

Mosaic chromosome Y loss and testicular germ cell tumor risk

(2017) Mitchell J Machiela et al.   JOURNAL OF HUMAN GENETICS

Y Chromosome Missing Protein, TBL1Y, May Play an Important Role in Cardiac Differentiation

(2017) Anna Meyfour et al.   JOURNAL OF PROTEOME RESEARCH

Chromosome-Centric Human Proteome Project Allies with Developmental Biology: A Case Study of the Role of Y Chromosome Genes in Organ Development

(2017) Anna Meyfour et al.   JOURNAL OF PROTEOME RESEARCH

Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9

(2017) Fatwa Adikusuma et al.   MOLECULAR THERAPY

Folate deficiency induces mitotic aberrations and chromosomal instability by compromising the spindle assembly checkpoint in cultured human colon cells

(2017) Xihan Guo et al.   MUTAGENESIS

Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility

(2017) Daniel J Wright et al.   NATURE GENETICS

Human Y-chromosome variation in the genome-sequencing era

(2017) Mark A. Jobling et al.   NATURE REVIEWS GENETICS

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma

(2017) Madeleine Arseneault et al.   Scientific Reports

Loss of Y Chromosome in Blood Is Associated With Major Cardiovascular Events During Follow-Up in Men After Carotid EndarterectomyCLINICAL PERSPECTIVE

(2017) Saskia Haitjema et al.   Circulation-Cardiovascular Genetics

Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity

(2017) Jin Xu et al.   eLife

A Novel Y-Specific Long Non-Coding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosis-related Genes

(2017) Elsa Molina et al.   Scientific Reports

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

(2016) Jan P. Dumanski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ANGPTL2 is associated with an increased risk of cardiovascular events and death in diabetic patients

(2016) Barnabas Gellen et al.   DIABETOLOGIA

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

(2016) Alexandra Kautzky-Willer et al.   ENDOCRINE REVIEWS

Phyllanthus emblica Fruit Extract Activates Spindle Assembly Checkpoint, Prevents Mitotic Aberrations and Genomic Instability in Human Colon Epithelial NCM460 Cells

(2016) Xihan Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases

(2016) Melissa Christine Kander et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Relationship between spontaneous frequency of aneuploidy and cancer risk in 2145 healthy Hungarian subjects

(2016) Gyöngyi Farkas et al.   MUTAGENESIS

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

Mosaic loss of chromosome Y is associated with common variation near TCL1A

(2016) Weiyin Zhou et al.   NATURE GENETICS

Micronucleus formation causes perpetual unilateral chromosome inheritance in mouse embryos

(2016) Cayetana Vázquez-Diez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

(2016) Mitchell J. Machiela et al.   Nature Communications

ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism

(2016) Zhe Tian et al.   Nature Communications

Loss of Y Chromosome in Peripheral Blood of Colorectal and Prostate Cancer Patients

(2016) Predrag Noveski et al.   PLoS One

Selective advantage of trisomic human cells cultured in non-standard conditions

(2016) Samuel D. Rutledge et al.   Scientific Reports

Characterization of Large Structural Genetic Mosaicism in Human Autosomes

(2015) Mitchell J. Machiela et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The fragile Y hypothesis: Y chromosome aneuploidy as a selective pressure in sex chromosome and meiotic mechanism evolution

(2015) Heath Blackmon et al.   BIOESSAYS

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

(2015) Daniele Fachinetti et al.   DEVELOPMENTAL CELL

New data shed light on Y-loss-related pathogenesis in myelodysplastic syndromes

(2015) Christina Ganster et al.   GENES CHROMOSOMES & CANCER

DDX3Y, a Male-Specific Region of Y Chromosome Gene, May Modulate Neuronal Differentiation

(2015) Haghighat Vakilian et al.   JOURNAL OF PROTEOME RESEARCH

Two Splice Variants of Y Chromosome-Located Lysine-Specific Demethylase 5D Have Distinct Function in Prostate Cancer Cell Line (DU-145)

(2015) Zohreh Jangravi et al.   JOURNAL OF PROTEOME RESEARCH

The Y-chromosome point mutation rate in humans

(2015) Agnar Helgason et al.   NATURE GENETICS

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

(2015) Hong Yuen Wong et al.   Oncotarget

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

How homologous recombination maintains telomere integrity

(2014) Eliana M. C. Tacconi et al.   CHROMOSOMA

Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators

(2014) Daniel W. Bellott et al.   NATURE

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

(2014) Lars A Forsberg et al.   NATURE GENETICS

Identification of specific Y chromosomes associated with increased prostate cancer risk

(2014) Lisa A. Cannon-Albright et al.   PROSTATE

Smoking is associated with mosaic loss of chromosome Y

(2014) J. P. Dumanski et al.   SCIENCE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Y chromosome loss in male patients with primary biliary cirrhosis

(2013) Ana Lleo et al.   JOURNAL OF AUTOIMMUNITY

Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration

(2013) Doris Bachtrog   NATURE REVIEWS GENETICS

A genomic view of mosaicism and human disease

(2013) Leslie G. Biesecker et al.   NATURE REVIEWS GENETICS

The male-specific factor Sry harbors an oncogenic function

(2013) S Murakami et al.   ONCOGENE

Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity

(2013) N. Jahanshad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunosurveillance as a regulator of tissue homeostasis

(2013) Laura Senovilla et al.   TRENDS IN IMMUNOLOGY

Cancer cells preferentially lose small chromosomes

(2012) Pascal H.G. Duijf et al.   INTERNATIONAL JOURNAL OF CANCER

Detectable clonal mosaicism and its relationship to aging and cancer

(2012) Kevin B Jacobs et al.   NATURE GENETICS

Detectable clonal mosaicism from birth to old age and its relationship to cancer

(2012) Cathy C Laurie et al.   NATURE GENETICS

Gender Differences in Cancer Susceptibility: An Inadequately Addressed Issue

(2012) M. Tevfik Dorak et al.   Frontiers in Genetics

Live-Cell Chromosome Dynamics and Outcome of X Chromosome Pairing Events during ES Cell Differentiation

(2011) Osamu Masui et al.   CELL

Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis

(2011) Luca Persani et al.   JOURNAL OF AUTOIMMUNITY

The aneuploidy paradox: costs and benefits of an incorrect karyotype

(2011) Jason M. Sheltzer et al.   TRENDS IN GENETICS

Whole chromosome loss is promoted by telomere dysfunction in primary cells

(2010) Judit Pampalona et al.   GENES CHROMOSOMES & CANCER

Isodicentric Y Chromosomes and Sex Disorders as Byproducts of Homologous Recombination that Maintains Palindromes

(2009) Julian Lange et al.   CELL

Y chromosome structural and functional changes in human malignant diseases

(2009) Néstor O. Bianchi   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The Aneuploidy Paradox in Cell Growth and Tumorigenesis

(2008) Beth A. Weaver et al.   CANCER CELL

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

(2008) Kazuki Yasuda et al.   NATURE GENETICS

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

(2008) Hiroyuki Unoki et al.   NATURE GENETICS

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE