Loss of Y chromosome: An emerging next-generation biomarker for disease prediction and early detection?

Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes

(2021) Weiyin Zhou et al.   Scientific Reports

Chromosome Y loss and drivers of clonal hematopoiesis in myelodysplastic syndrome

(2021) Panagiotis Baliakas et al.   HAEMATOLOGICA

Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis

(2021) Tsuyoshi Hachiya et al.   Scientific Reports

Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

(2021) Jan P. Dumanski et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deletions on Chromosome Y and Downregulation of the SRY Gene in Tumor Tissue Are Associated with Worse Survival of Glioblastoma Patients

(2021) Małgorzata Łysiak et al.   Cancers

Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations

(2021) Xueqin Dai et al.   AGEING RESEARCH REVIEWS

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

(2021) Seyedeh M. Zekavat et al.   NATURE MEDICINE

Mosaic loss of human Y chromosome: what, how and why

(2020) Xihan Guo et al.   HUMAN GENETICS

A brief history of human disease genetics

(2020) Melina Claussnitzer et al.   NATURE

Extreme down-regulation of chromosome Y and Alzheimer’s disease in men

(2020) Alejandro Caceres et al.   NEUROBIOLOGY OF AGING

Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men

(2020) Shu-Hong Lin et al.   Scientific Reports

Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells

(2020) Madhu M. Ouseph et al.   HAEMATOLOGICA

Loss of Y-Chromosome during Male Breast Carcinogenesis

(2020) Marie Colombe Agahozo et al.   Cancers

Understanding the birth of rupture-prone and irreparable micronuclei

(2020) Xihan Guo et al.   CHROMOSOMA

Chromosomal alterations among age-related haematopoietic clones in Japan

(2020) Chikashi Terao et al.   NATURE

Monogenic and polygenic inheritance become instruments for clonal selection

(2020) Po-Ru Loh et al.   NATURE

Unraveling Hematopoiesis through the Lens of Genomics

(2020) L. Alexander Liggett et al.   CELL

Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes

(2020) Xihan Guo et al.   INTERNATIONAL JOURNAL OF CANCER

The genomic landscapes of individual melanocytes from human skin

(2020) Jessica Tang et al.   NATURE

Genomic copy number predicts esophageal cancer years before transformation

(2020) Sarah Killcoyne et al.   NATURE MEDICINE

Investigation of LOY in Prostate, Pancreatic, and Colorectal Cancers in males: A case–control study

(2020) Ambreen Asim et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

(2019) Peter Ly et al.   NATURE GENETICS

Somatic mosaicism of sex chromosomes in the blood and brain

(2019) Emma J. Graham et al.   BRAIN RESEARCH

Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

(2019) Marcus Danielsson et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Loss of the Y chromosome predicts a high relapse risk in younger adult male patients with t(8;21) acute myeloid leukemia on high-dose cytarabine consolidation therapy: a retrospective multicenter study

(2019) Wei Zhou et al.   LEUKEMIA & LYMPHOMA

Genetic predisposition to mosaic Y chromosome loss in blood

(2019) Deborah J. Thompson et al.   NATURE

GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

(2019) Chikashi Terao et al.   Nature Communications

Why Y? Down-regulation of chromosome Y genes potentially contributes to elevated cancer risk

(2019) Derek W Brown et al.   JNCI-Journal of the National Cancer Institute

Extreme down-regulation of chromosome Y and cancer risk in men

(2019) Alejandro Cáceres et al.   JNCI-Journal of the National Cancer Institute

The GenomeAsia 100K Project enables genetic discoveries across Asia

(2019)   NATURE

Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study

(2018) Jason Y.Y. Wong et al.   ENVIRONMENT INTERNATIONAL

Loss of chromosome Y in blood, but not in brain, of suicide completers

(2018) Atsushi Kimura et al.   PLoS One

Quantitation of the cellular content of saliva and buccal swab samples

(2018) Christiane Theda et al.   Scientific Reports

Y chromosome mosaicism is associated with age-related macular degeneration

(2018) Felix Grassmann et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mosaic Turner syndrome shows reduced penetrance in an adult population study

(2018) Marcus A. Tuke et al.   GENETICS IN MEDICINE

Association of mosaic loss of chromosome Y with lung cancer risk and prognosis in a Chinese population

(2018) Na Qin et al.   Journal of Thoracic Oncology

Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

(2018) Po-Ru Loh et al.   NATURE

Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank

(2018) Erikka Loftfield et al.   Scientific Reports

Mosaic Y loss is moderately associated with solid tumor risk

(2018) Erikka Loftfield et al.   CANCER RESEARCH

Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma

(2018) Robert Hollows et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem

(2018) Xihan Guo et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Mosaic loss of chromosome Y in leukocytes matters

(2018) Lars A. Forsberg et al.   NATURE GENETICS

Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’

(2018) Weiyin Zhou et al.   NATURE GENETICS

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis

(2017) Curtis J. Henry et al.   HAEMATOLOGICA

Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men

(2017) Lars A. Forsberg   HUMAN GENETICS

Mosaic chromosome Y loss and testicular germ cell tumor risk

(2017) Mitchell J Machiela et al.   JOURNAL OF HUMAN GENETICS

Folate deficiency induces mitotic aberrations and chromosomal instability by compromising the spindle assembly checkpoint in cultured human colon cells

(2017) Xihan Guo et al.   MUTAGENESIS

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility

(2017) Daniel J Wright et al.   NATURE GENETICS

Loss of Y Chromosome in Blood Is Associated With Major Cardiovascular Events During Follow-Up in Men After Carotid EndarterectomyCLINICAL PERSPECTIVE

(2017) Saskia Haitjema et al.   Circulation-Cardiovascular Genetics

Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis

(2017) Curtis J. Henry et al.   HAEMATOLOGICA

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

(2016) Jan P. Dumanski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Vitamin C Facilitates Demethylation of theFoxp3Enhancer in a Tet-Dependent Manner

(2016) Varun Sasidharan Nair et al.   JOURNAL OF IMMUNOLOGY

Use of the lymphocyte cytokinesis-block micronucleus assay in occupational biomonitoring of genome damage caused by in vivo exposure to chemical genotoxins: Past, present and future

(2016) Armen Nersesyan et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

Mosaic loss of chromosome Y is associated with common variation near TCL1A

(2016) Weiyin Zhou et al.   NATURE GENETICS

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

(2016) Mitchell J. Machiela et al.   Nature Communications

Characterization of Large Structural Genetic Mosaicism in Human Autosomes

(2015) Mitchell J. Machiela et al.   AMERICAN JOURNAL OF HUMAN GENETICS

New data shed light on Y-loss-related pathogenesis in myelodysplastic syndromes

(2015) Christina Ganster et al.   GENES CHROMOSOMES & CANCER

TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer

(2015) Hong Yuen Wong et al.   Oncotarget

A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly

(2014) V Chouraki et al.   MOLECULAR PSYCHIATRY

Commentary: Critical questions, misconceptions and a road map for improving the use of the lymphocyte cytokinesis-block micronucleus assay for in vivo biomonitoring of human exposure to genotoxic chemicals—A HUMN project perspective

(2014) Micheline Kirsch-Volders et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

(2014) Lars A Forsberg et al.   NATURE GENETICS

Smoking is associated with mosaic loss of chromosome Y

(2014) J. P. Dumanski et al.   SCIENCE

Sex chromosome loss may represent a disease-associated clonal population in chronic lymphocytic leukemia

(2013) Elise Chapiro et al.   GENES CHROMOSOMES & CANCER

The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease

(2013) L. K. Case et al.   GENOME RESEARCH

Y chromosome loss in male patients with primary biliary cirrhosis

(2013) Ana Lleo et al.   JOURNAL OF AUTOIMMUNITY

Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells

(2012) Lars A. Forsberg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Detectable clonal mosaicism and its relationship to aging and cancer

(2012) Kevin B Jacobs et al.   NATURE GENETICS

Detectable clonal mosaicism from birth to old age and its relationship to cancer

(2012) Cathy C Laurie et al.   NATURE GENETICS

Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis

(2011) Luca Persani et al.   JOURNAL OF AUTOIMMUNITY

Chronic alcohol exposure induces genome damage measured using the cytokinesis-block micronucleus cytome assay and aneuploidy in human B lymphoblastoid cell lines

(2011) B. Benassi-Evans et al.   MUTAGENESIS

Admixture mapping of end stage kidney disease genetic susceptibility using estimated mutual information ancestry informative markers

(2010) Liran I Shlush et al.   BMC Medical Genomics

Loss of the Y chromosome in Philadelphia-positive cells predicts a poor response of chronic myeloid leukemia patients to imatinib mesylate therapy

(2010) E. Lippert et al.   HAEMATOLOGICA