Small but strong: Mutational and functional landscapes of micronuclei in cancer genomes

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

(2020) Maria Grazia Vizioli et al.   GENES & DEVELOPMENT

Mosaic loss of human Y chromosome: what, how and why

(2020) Xihan Guo et al.   HUMAN GENETICS

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

(2020) Isidro Cortés-Ciriano et al.   NATURE GENETICS

Stem Cell DNA Damage and Genome Mutation in the Context of Aging and Cancer Initiation

(2020) Lara Al zouabi et al.   Cold Spring Harbor Perspectives in Biology

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

(2020) Yuka Nakazawa et al.   CELL

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

(2020) Ana Tufegdžić Vidaković et al.   CELL

DNA damage induced during mitosis undergoes DNA repair synthesis

(2020) Veronica Gomez Godinez et al.   PLoS One

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

The landscape of chromothripsis across adult cancer types

(2020) Natalia Voronina et al.   Nature Communications

Long-term fate of etoposide-induced micronuclei and micronucleated cells in Hela-H2B-GFP cells

(2020) Hauke Reimann et al.   ARCHIVES OF TOXICOLOGY

How to maintain the genome in nuclear space

(2020) Ioanna Mitrentsi et al.   CURRENT OPINION IN CELL BIOLOGY

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

(2020) Marina Vietri et al.   NATURE CELL BIOLOGY

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

(2020) John Maciejowski et al.   NATURE GENETICS

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

(2019) Peter Ly et al.   NATURE GENETICS

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

(2019) Lin Deng et al.   MOLECULAR CELL

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

(2019) Jessica Willan et al.   Oncogenesis

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle

(2019) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

The roles of kinetochore of micronucleus in mitosis of HeLa cells: a live cell imaging study

(2019) Erkang Jiang et al.   Cancer Cell International

Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

(2019) Hui Jiang et al.   EMBO JOURNAL

Context is everything: aneuploidy in cancer

(2019) Uri Ben-David et al.   NATURE REVIEWS GENETICS

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

(2019) Remi Sonneville et al.   eLife

Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis

(2019) Pantelias et al.   Cancers

Morphofunctional Differences of Micronuclei in Cultures of Human p53-Positive and p53-Negative Tumor Cells

(2019) O. I. Sutyagina et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Double‐strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation

(2019) Yoshihiro Oobatake et al.   GENES CHROMOSOMES & CANCER

Cellular survival over genomic perfection

(2019) Serena Nik-Zainal et al.   SCIENCE

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

(2019) Maja Kneissig et al.   eLife

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma

(2019) Richard P. Koche et al.   NATURE GENETICS

Active DNA end processing in micronuclei of ovarian cancer cells

(2018) Zizhi Tang et al.   BMC CANCER

Aneuploidy: Cancer strength or vulnerability?

(2018) Giorgia Simonetti et al.   INTERNATIONAL JOURNAL OF CANCER

Chromosomes trapped in micronuclei are liable to segregation errors

(2018) Mar Soto et al.   JOURNAL OF CELL SCIENCE

Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells

(2018) Teressa Paulsen et al.   TRENDS IN GENETICS

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

(2018) Theo A. Knijnenburg et al.   Cell Reports

Chromothripsis, a credible chromosomal mechanism in evolutionary process

(2018) Franck Pellestor et al.   CHROMOSOMA

Altered nuclear envelope structure and proteasome function of micronuclei

(2018) Kendra K. Maass et al.   EXPERIMENTAL CELL RESEARCH

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

Micronucleus formation in human cancer cells is biased by chromosome size

(2018) Tilmann Bochtler et al.   GENES CHROMOSOMES & CANCER

The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem

(2018) Xihan Guo et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

Homologous Recombination and the Formation of Complex Genomic Rearrangements

(2018) Aurèle Piazza et al.   TRENDS IN CELL BIOLOGY

Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells

(2017) Ayeong So et al.   FEBS Journal

Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair

(2017) Vincent Duheron et al.   JOURNAL OF CELL SCIENCE

Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events

(2017) Douglas R. Mackay et al.   JOURNAL OF CELL SCIENCE

CDK1 and PLK1 coordinate the disassembly and reassembly of the nuclear envelope in vertebrate mitosis

(2017) Ines J de Castro et al.   Oncotarget

Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells

(2017) Roshan L. Shrestha et al.   Oncotarget

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

(2017) Mar Soto et al.   Cell Reports

Cancer cells that survive checkpoint adaptation contain micronuclei that harbor damaged DNA

(2016) Cody W. Lewis et al.   CELL CYCLE

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

Micronucleus formation causes perpetual unilateral chromosome inheritance in mouse embryos

(2016) Cayetana Vázquez-Diez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

(2016) Alberto Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis

(2015) Georgia I. Terzoudi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin Dynamics during DNA Repair Revealed by Pair Correlation Analysis of Molecular Flow in the Nucleus

(2014) Elizabeth Hinde et al.   BIOPHYSICAL JOURNAL

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

(2014) A. Orthwein et al.   SCIENCE

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

Punctuated Evolution of Prostate Cancer Genomes

(2013) Sylvan C. Baca et al.   CELL

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Regulation of Nucleotide Excision Repair by Nuclear Lamin B1

(2013) Veronika Butin-Israeli et al.   PLoS One

Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer

(2013) Kyle R. Cron et al.   PLoS One

DNA Damage Response: Three Levels of DNA Repair Regulation

(2013) B. M. Sirbu et al.   Cold Spring Harbor Perspectives in Biology

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response

(2012) C Lemaître et al.   ONCOGENE

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements

(2011) Pengfei Liu et al.   CELL

DNA replication occurs in all lamina positive micronuclei, but never in lamina negative micronuclei

(2011) A. Okamoto et al.   MUTAGENESIS

Nuclear envelope defects impede a proper response to micronuclear DNA lesions

(2011) Mariona Terradas et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Generation of Micronuclei during Interphase by Coupling between Cytoplasmic Membrane Blebbing and Nuclear Budding

(2011) Koh-ichi Utani et al.   PLoS One

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Molecular mechanisms of the origin of micronuclei from extrachromosomal elements

(2010) N. Shimizu   MUTAGENESIS

GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage

(2010) Ruifeng Guo et al.   NUCLEIC ACIDS RESEARCH

Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress

(2010) Koh-ichi Utani et al.   PLoS One

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY