Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain

(2016) Dan Xia et al.   NEURON

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease

(2015) Dan Xia et al.   NEURON

Structural basis of human γ-secretase assembly

(2015) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ

(2014) Marty A. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional structure of human γ-secretase

(2014) Peilong Lu et al.   NATURE

Highly efficient production of the Alzheimer's γ-Secretase integral membrane protease complex by a multi-gene stable integration approach

(2013) Jean-René Alattia et al.   BIOTECHNOLOGY AND BIOENGINEERING

Signature Amyloid β Profiles Are Produced by Different γ-Secretase Complexes

(2013) Hermien Acx et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-Dominant Negative Effects of Pathogenic PSEN1 Mutations on  -Secretase Activity and A  Production

(2013) E. A. Heilig et al.   JOURNAL OF NEUROSCIENCE

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes

(2012) Matthias Cacquevel et al.   PLoS One

Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations

(2011) Omar Quintero-Monzon et al.   BIOCHEMISTRY

A Presenilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of γ-Secretase Activity

(2010) Elizabeth A. Heilig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

(2010) S. W. Pimplikar et al.   JOURNAL OF NEUROSCIENCE

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Clinical Picture of a Patient With a Novel PSEN1 Mutation (L424V)

(2008) A. Robles et al.   American Journal of Alzheimers Disease and Other Dementias

Amyloid plaque imaging in vivo: current achievement and future prospects

(2008) Agneta Nordberg   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The ART of Loss: Aβ Imaging in the Evaluation of Alzheimer’s Disease and other Dementias

(2008) Victor L. Villemagne et al.   MOLECULAR NEUROBIOLOGY

Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP

(2008) Rita Joao Guerreiro et al.   NEUROBIOLOGY OF AGING