Strategies for uncovering stable isotope tracing patterns between cell populations

Slow TCA flux and ATP production in primary solid tumours but not metastases

(2023) Caroline R. Bartman et al.   NATURE

Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem

(2023) Michaela Schwaiger-Haber et al.   Nature Communications

‘On the Spot’ Digital Pathology of Breast Cancer Based on Single-Cell Mass Spectrometry Imaging

(2022) Eva Cuypers et al.   ANALYTICAL CHEMISTRY

Carbon source availability drives nutrient utilization in CD8+ T cells

(2022) Irem Kaymak et al.   Cell Metabolism

13C metabolic flux analysis clarifies distinct metabolic phenotypes of cancer cell spheroid mimicking tumor hypoxia

(2022) Shingo Noguchi et al.   METABOLIC ENGINEERING

Principles of reproducible metabolite profiling of enriched lymphocytes in tumors and ascites from human ovarian cancer

(2022) Marisa K. Kilgour et al.   Nature Protocols

In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors

(2022) Panayotis Pachnis et al.   Science Advances

Evaluation of Formalin-Fixed and FFPE Tissues for Spatially Resolved Metabolomics and Drug Distribution Studies

(2022) Andreas Dannhorn et al.   Pharmaceuticals

Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments

(2022) Adam J. Rauckhorst et al.   Molecular Metabolism

Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets

(2022) Bo Jin et al.   Acta Pharmaceutica Sinica B

Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity

(2022) Xinyi Zhang et al.   Cancer & Metabolism

Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

(2021) Andrew W DeVilbiss et al.   eLife

1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

(2021) Marisa K. Kilgour et al.   Science Advances

Spatially Resolved Mass Spectrometry at the Single Cell: Recent Innovations in Proteomics and Metabolomics

(2021) Michael J. Taylor et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

SpaceM reveals metabolic states of single cells

(2021) Luca Rappez et al.   NATURE METHODS

Stable isotope tracing to assess tumor metabolism in vivo

(2021) Brandon Faubert et al.   Nature Protocols

Interrogating in vivo T-cell metabolism in mice using stable isotope labeling metabolomics and rapid cell sorting

(2021) Ryan D. Sheldon et al.   Nature Protocols

Isotopically nonstationary 13C metabolic flux analysis in resting and activated human platelets

(2021) Cara L. Sake et al.   METABOLIC ENGINEERING

Physiological impact of in vivo stable isotope tracing on cancer metabolism

(2021) Manuel Grima-Reyes et al.   Molecular Metabolism

Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal

(2020) Tobias Baumann et al.   NATURE IMMUNOLOGY

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance

(2020) Nick van Gastel et al.   Cell Metabolism

In Vivo Estimates of Liver Metabolic Flux Assessed by 13C-Propionate and 13C-Lactate Are Impacted by Tracer Recycling and Equilibrium Assumptions

(2020) Clinton M. Hasenour et al.   Cell Reports

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

(2020) Allison N Lau et al.   eLife

Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle

(2020) Shiyu Liu et al.   Cell Metabolism

The tumor microenvironment

(2020) Nicole M. Anderson et al.   CURRENT BIOLOGY

FACS-Based Proteomics Enables Profiling of Proteins in Rare Cell Populations

(2020) Evelyne Maes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor

(2019) Jing-Yiing Wu et al.   MOLECULAR CELL

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

Sorting cells alters their redox state and cellular metabolome

(2018) Elizabeth M. Llufrio et al.   Redox Biology

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

(2018) Kevin D. Courtney et al.   Cell Metabolism

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

(2018) Marion Curtis et al.   Cell Metabolism

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells

(2016) Irena Roci et al.   ANALYTICAL CHEMISTRY

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

FDR-controlled metabolite annotation for high-resolution imaging mass spectrometry

(2016) Andrew Palmer et al.   NATURE METHODS

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY