Physiological impact of in vivo stable isotope tracing on cancer metabolism

The Source of Glycolytic Intermediates in Mammalian Tissues

(2021) Tara TeSlaa et al.   Cell Metabolism

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

(2021) Mylène Tajan et al.   Nature Communications

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

(2021) Nicholas J. Rossiter et al.   Cell Metabolism

Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver

(2021) Fuad J. Naser et al.   Cell Metabolism

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

Amino acids in cancer

(2020) Elizabeth L. Lieu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo

(2020) Juan Fernández-García et al.   TRENDS IN BIOCHEMICAL SCIENCES

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia

(2020) Martina Chiu et al.   Frontiers in Oncology

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

(2020) Juan C. García-Cañaveras et al.   LEUKEMIA

Dietary modifications for enhanced cancer therapy

(2020) Naama Kanarek et al.   NATURE

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance

(2020) Nick van Gastel et al.   Cell Metabolism

Quantitative Fluxomics of Circulating Metabolites

(2020) Sheng Hui et al.   Cell Metabolism

The role of asparagine synthetase on nutrient metabolism in pancreatic disease

(2020) Cheng-Yu Tsai et al.   PANCREATOLOGY

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

(2020) Bryan Ngo et al.   Cancer Discovery

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

(2020) Allison N Lau et al.   eLife

Metabolite AutoPlotter - an application to process and visualise metabolite data in the web browser

(2020) Matthias Pietzke et al.   Cancer & Metabolism

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

(2020) Gianmarco Rinaldi et al.   MOLECULAR CELL

Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics

(2020) Holden C. Williams et al.   Metabolites

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

(2019) Yuanyuan Wang et al.   Nature Communications

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

(2019) Johan Vande Voorde et al.   Science Advances

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

(2019) Min Yuan et al.   Nature Protocols

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting

(2019) Mark R. Sullivan et al.   Cell Metabolism

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

The Diverse Functions of Non-Essential Amino Acids in Cancer

(2019) Bo-Hyun Choi et al.   Cancers

Metabolite Exchange between Mammalian Organs Quantified in Pigs

(2019) Cholsoon Jang et al.   Cell Metabolism

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

(2019) Xia Gao et al.   NATURE

Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running

(2019) Simon Lønbro et al.   PLoS One

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Targeting extracellular nutrient dependencies of cancer cells

(2019) Javier Garcia-Bermudez et al.   Molecular Metabolism

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids

(2018) Cholsoon Jang et al.   Cell Metabolism

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer

(2018) Yongliang Wang et al.   Cell Reports

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

(2018) Xiaojing Liu et al.   CELL

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

(2018) Thomas Bertero et al.   Cell Metabolism

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

(2017) Jessica B. Spinelli et al.   SCIENCE

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing

(2017) Ramon C. Sun et al.   Nature Communications

Human splanchnic amino-acid metabolism

(2016) Evelien P. J. G. Neis et al.   AMINO ACIDS

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points—a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine

(2016) Børge G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

Pivotal role of glutamine synthetase in ammonia detoxification

(2016) Theodorus B.M. Hakvoort et al.   HEPATOLOGY

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

(2016) Michael E Pacold et al.   Nature Chemical Biology

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Circadian Metabolism: From Mechanisms to Metabolomics and Medicine

(2016) Steven A. Brown   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Daily Eating Patterns and Their Impact on Health and Disease

(2016) Amir Zarrinpar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

(2015) Shiran Rabinovich et al.   NATURE

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

(2015) Sriram Venneti et al.   Science Translational Medicine

Intravenous glutamine supplementation enhances renal de novo arginine synthesis in humans: a stable isotope study

(2014) Nikki Buijs et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides

(2014) Yaarit Adamovich et al.   Cell Metabolism

Comparison of bolus injection and constant infusion methods for measuring muscle protein fractional synthesis rate in humans

(2014) Demidmaa Tuvdendorj et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation

(2012) Maarten R. Soeters et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

(2012) Wan Zhang et al.   NATURE CELL BIOLOGY

Metabolism of [U-13C]glucose in human brain tumorsin vivo

(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Is Glutamine a Conditionally Essential Amino Acid?

(2010) Janet M. Lacey et al.   NUTRITION REVIEWS

Amino acids: metabolism, functions, and nutrition

(2009) Guoyao Wu   AMINO ACIDS

Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression

(2009) Christopher Vollmers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA