Carbon source availability drives nutrient utilization in CD8+ T cells

Metabolic adaptation of lymphocytes in immunity and disease

(2022) Nicole M. Chapman et al.   IMMUNITY

Clinically-relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function

(2022) Sarah MacPherson et al.   Molecular Therapy-Methods & Clinical Development

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

(2021) Ke Xu et al.   SCIENCE

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

(2021) Nicholas J. Rossiter et al.   Cell Metabolism

Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response

(2021) Lauren S. Levine et al.   IMMUNITY

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Interrogating in vivo T-cell metabolism in mice using stable isotope labeling metabolomics and rapid cell sorting

(2021) Ryan D. Sheldon et al.   Nature Protocols

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

(2020) Dominic G. Roy et al.   Cell Metabolism

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity

(2020) Dalton Hermans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

(2020) Jean-Christophe Beltra et al.   IMMUNITY

Quantitative Fluxomics of Circulating Metabolites

(2020) Sheng Hui et al.   Cell Metabolism

TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells

(2020) Takuya Sekine et al.   Science Immunology

Single-cell metabolic profiling of human cytotoxic T cells

(2020) Felix J. Hartmann et al.   NATURE BIOTECHNOLOGY

Immunometabolic Interplay in the Tumor Microenvironment

(2020) Irem Kaymak et al.   CANCER CELL

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

(2020) Rafael J. Argüello et al.   Cell Metabolism

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

(2020) Alba Luengo et al.   MOLECULAR CELL

Lactate Limits T Cell Proliferation via the NAD(H) Redox State

(2020) William J. Quinn et al.   Cell Reports

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

(2019) Johan Vande Voorde et al.   Science Advances

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

(2019) Chen Yao et al.   NATURE IMMUNOLOGY

T Cell Activation Depends on Extracellular Alanine

(2019) Noga Ron-Harel et al.   Cell Reports

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

The Rise of Physiologic Media

(2019) Jason R. Cantor   TRENDS IN CELL BIOLOGY

Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

(2019) Alexander Lercher et al.   IMMUNITY

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

(2018) Alexander Muir et al.   Disease Models & Mechanisms

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

(2017) Benjamin A. Olenchock et al.   IMMUNITY

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

(2017) Shona A. Mookerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

FluxFix: automatic isotopologue normalization for metabolic tracer analysis

(2016) Sophie Trefely et al.   BMC BIOINFORMATICS

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Systems-level analysis of mechanisms regulating yeast metabolic flux

(2016) S. R. Hackett et al.   SCIENCE

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

(2015) Takla Griss et al.   PLOS BIOLOGY

INCA: a computational platform for isotopically non-stationary metabolic flux analysis

(2014) J. D. Young   BIOINFORMATICS

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

In Vivo RNA Interference Screens Identify Regulators of Antiviral CD4+ and CD8+ T Cell Differentiation

(2014) Runqiang Chen et al.   IMMUNITY

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Pathogen-Induced Inflammatory Environment Controls Effector and Memory CD8 + T Cell Differentiation

(2011) Joshua J. Obar et al.   JOURNAL OF IMMUNOLOGY

MMMDB: Mouse Multiple Tissue Metabolome Database

(2011) Masahiro Sugimoto et al.   NUCLEIC ACIDS RESEARCH

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

GAGE: generally applicable gene set enrichment for pathway analysis

(2009) Weijun Luo et al.   BMC BIOINFORMATICS

Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development

(2009) E. Teixeiro et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE