Interrogating in vivo T-cell metabolism in mice using stable isotope labeling metabolomics and rapid cell sorting

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo

(2020) Juan Fernández-García et al.   TRENDS IN BIOCHEMICAL SCIENCES

NOREVA: enhanced normalization and evaluation of time-course and multi-class metabolomic data

(2020) Qingxia Yang et al.   NUCLEIC ACIDS RESEARCH

Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

(2020) Allison N Lau et al.   eLife

Immunometabolic Interplay in the Tumor Microenvironment

(2020) Irem Kaymak et al.   CANCER CELL

Immunometabolism in the Tumor Microenvironment

(2020) Dominic G. Roy et al.   Annual Review of Cancer Biology-Series

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

(2019) Johan Vande Voorde et al.   Science Advances

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

(2019) Min Yuan et al.   Nature Protocols

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

(2019) Ricardo J. Miragaia et al.   IMMUNITY

Acetate Promotes T Cell Effector Function during Glucose Restriction

(2019) Jing Qiu et al.   Cell Reports

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

(2019) Sean C. Tompkins et al.   Cell Reports

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

The Rise of Physiologic Media

(2019) Jason R. Cantor   TRENDS IN CELL BIOLOGY

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

(2019) Peter A. Szabo et al.   Nature Communications

Ketogenic diet activates protective γδ T cell responses against influenza virus infection

(2019) Emily L. Goldberg et al.   Science Immunology

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids

(2018) Cholsoon Jang et al.   Cell Metabolism

Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer

(2018) Yongliang Wang et al.   Cell Reports

Sorting cells alters their redox state and cellular metabolome

(2018) Elizabeth M. Llufrio et al.   Redox Biology

Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks

(2018) Kenneth A. Dyar et al.   CELL

Trace Phosphate Improves ZIC-pHILIC Peak Shape, Sensitivity, and Coverage for Untargeted Metabolomics

(2018) Jonathan L. Spalding et al.   JOURNAL OF PROTEOME RESEARCH

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR

(2018) Paul Heinrich et al.   Scientific Reports

Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle

(2018) Kenichiro Kinouchi et al.   Cell Reports

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

(2017) Walter W Chen et al.   Nature Protocols

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing

(2017) Ramon C. Sun et al.   Nature Communications

Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance

(2016) Lesley K. Rao et al.   ANESTHESIOLOGY

FluxFix: automatic isotopologue normalization for metabolic tracer analysis

(2016) Sophie Trefely et al.   BMC BIOINFORMATICS

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

(2016) Annelies Quaegebeur et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Targeting T cell metabolism for therapy

(2015) David O'Sullivan et al.   TRENDS IN IMMUNOLOGY

Impact of Anesthesia and Euthanasia on Metabolomics of Mammalian Tissues: Studies in a C57BL/6J Mouse Model

(2015) Katherine A. Overmyer et al.   PLoS One

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation

(2013) J Adam Best et al.   NATURE IMMUNOLOGY

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

Evaluating the glucose tolerance test in mice

(2008) Sofianos Andrikopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY