13C metabolic flux analysis clarifies distinct metabolic phenotypes of cancer cell spheroid mimicking tumor hypoxia

Challenges of applying multicellular tumor spheroids in preclinical phase

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Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

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Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer

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Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells

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Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies

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3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

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Reductive carboxylation supports redox homeostasis during anchorage-independent growth

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Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

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Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma

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Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data

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Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

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Metabolic characterization of cultured mammalian cells by mass balance analysis, tracer labeling experiments and computer-aided simulations

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Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

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Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

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Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

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IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

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Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport

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Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

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Rational design of 13C-labeling experiments for metabolic flux analysis in mammalian cells

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Parallel labeling experiments with [1,2-13C]glucose and [U-13C]glutamine provide new insights into CHO cell metabolism

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NIH Image to ImageJ: 25 years of image analysis

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A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

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Hallmarks of Cancer: The Next Generation

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

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pyOpt: a Python-based object-oriented framework for nonlinear constrained optimization

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Quiescent Fibroblasts Exhibit High Metabolic Activity

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Sensitive and Rapid Method for Amino Acid Quantitation in Malaria Biological Samples Using AccQ•Tag Ultra Performance Liquid Chromatography-Electrospray Ionization-MS/MS with Multiple Reaction Monitoring

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Effect of Anaplerotic Fluxes and Amino Acid Availability on Hepatic Lipoapoptosis

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Modeling Hybridoma Cell Metabolism Using a Generic Genome-Scale Metabolic Model of Mus musculus

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