Transition‐Metal‐Catalyzed Directed C−H Functionalization in/on Water

Transition-Metal-Catalyzed C–H Bond Activation for the Formation of C–C Bonds in Complex Molecules

(2023) Jamie H. Docherty et al.   Chemical Reviews

Redox-Neutral Site-Selective C–H Allylation and Iodolactonization of Benzoic Acids Using Morita–Baylis–Hillman Adducts in Water

(2023) Hemanga Bhattacharyya et al.   ORGANIC LETTERS

Sustainable Ruthenium(II)-Catalyzed C–H Activations in and on H2O

(2022) Nikolaos Kaplaneris et al.   ACS Sustainable Chemistry & Engineering

Aqueous Mediated Reactions Involving Hypervalent Iodine Reagents

(2022) Rinku Soni et al.   Asian Journal of Organic Chemistry

Transition-Metal-Catalyzed Directing-Group-Assisted C4-H Carbon–Carbon Bond Formation of Indole

(2022) Tharmalingam Punniyamurthy et al.   SYNLETT

Recent Advances in Copper Promoted Inert C(sp3)–H Functionalization

(2021) Yuhang Yang et al.   ACS Catalysis

A Water-Soluble Rhenium(I) Catalyst for the Regio- and Stereoselective C(sp2)–H Alkenylation of N-Pyridyl-/N-Pyrimidylindole and the N–H Alkenylation of N-Pyrimidylaniline Derivatives with Ynamides

(2021) Sundaramoorthi Sarathkumar et al.   ORGANIC LETTERS

2-(Pyridin-2-yl)isopropyl (PIP) Amine: An Enabling Directing Group for Divergent and Asymmetric Functionalization of Unactivated Methylene C(sp3)–H Bonds

(2021) Qi Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Transition‐Metal‐Catalyzed Directing Group Assisted (Hetero)aryl C−H Functionalization: Construction of C−C/C‐Heteroatom Bonds

(2021) Tanumay Sarkar et al.   CHEMICAL RECORD

Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(sp3)–H Bonds

(2021) Bin Liu et al.   CHEMICAL REVIEWS

Bidentate Directing Groups: An Efficient Tool in C–H Bond Functionalization Chemistry for the Expedient Construction of C–C Bonds

(2020) Supriya Rej et al.   CHEMICAL REVIEWS

From Pd(OAc)2 to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C–H Functionalization Reactions

(2020) Qian Shao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cross‐Dehydrogenative Coupling/Annulation of Arene Carboxylic Acids and Alkenes in Water with Ruthenium(II) Catalyst and Air

(2020) Anup Mandal et al.   Chemistry-An Asian Journal

Ruthenium(II)‐Catalyzed C‐H Annulation of Aromatic Acids with Alkynes Using Air as the Sole Oxidant in Water

(2020) Jiaping Wu et al.   ChemistrySelect

Recent Advances in Metal‐catalyzed Alkylation, Alkenylation and Alkynylation of Indole/indoline Benzenoid Nucleus

(2020) Sourav Pradhan et al.   Chemistry-An Asian Journal

Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions

(2020) Supriya Rej et al.   COORDINATION CHEMISTRY REVIEWS

Ruthenium-catalyzed C–H bond functionalization in cascade and one-pot transformations

(2020) Rafael Gramage-Doria et al.   COORDINATION CHEMISTRY REVIEWS

Ligand-Enabled Pd(II)-Catalyzed Iterative γ-C(sp3)−H Arylation of Free Aliphatic Acid

(2019) Pravas Dolui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploiting Strained Rings in Chelation Guided C‐H Functionalization: Integration of C‐H Activation with Ring Cleavage

(2019) Tharmalingam Punniyamurthy et al.   Chemistry-An Asian Journal

Hydrophilic (η6-Arene)–Ruthenium(II) Complexes with P–OH Ligands as Catalysts for the Isomerization of Allylbenzenes and C–H Bond Arylation Reactions in Water

(2019) Rebeca González-Fernández et al.   ORGANOMETALLICS

Iridium-Catalyzed Synthesis of Substituted Indanones from Aromatic Carboxylates and Unsaturated Ketones

(2019) Guodong Zhang et al.   ACS Catalysis

Ruthenium(II)‐Catalyzed C−H Bond [3+2] Annulation of N ‐Nitrosoanilines with Alkynes in Water

(2019) Xun Chen et al.   Asian Journal of Organic Chemistry

Additive-Free, Pd-Catalyzed 3-Amino-1-methyl-1H-pyridin-2-one-Directed C(sp2)–H Arylation and Methylation in Water

(2019) Trisha Mitra et al.   JOURNAL OF ORGANIC CHEMISTRY

Microwave-Promoted ortho -C−H Bond (Hetero)arylation of Arylpyrimidines in Water Catalyzed by Ruthenium(II)−Carboxylate

(2018) Miha Drev et al.   ChemCatChem

Regioselective direct arylation of indoles on the benzenoid moiety

(2018) Youqing Yang et al.   CHEMICAL COMMUNICATIONS

Rhodium(iii)-catalyzed chemodivergent annulations between N-methoxybenzamides and sulfoxonium ylides via C–H activation

(2018) Youwei Xu et al.   CHEMICAL COMMUNICATIONS

Rhodium(III)-Catalyzed C–H Functionalization in Water for Isoindolin-1-one Synthesis

(2018) Shangze Wu et al.   ORGANIC LETTERS

Visible-Light-Mediated Nickel(II)-Catalyzed C–N Cross-Coupling in Water: Green and Regioselective Access for the Synthesis of Pyrazole-Containing Compounds

(2018) Guirong You et al.   ORGANIC LETTERS

Transient Directing Groups for Transformative C–H Activation by Synergistic Metal Catalysis

(2018) Parthasarathy Gandeepan et al.   Chem

A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

(2018) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

Ruthenium(II)-Catalyzed Microwave-Promoted Multiple C–H Activation in Synthesis of Hexa(heteroaryl)benzenes in Water

(2018) Miha Drev et al.   ORGANIC LETTERS

3d Transition Metals for C–H Activation

(2018) Parthasarathy Gandeepan et al.   CHEMICAL REVIEWS

Rhodium(III)-catalyzed C-H alkylation of heterocycles with allylic alcohols in water: A reusable catalytic system for the synthesis of β-aryl ketones

(2018) Xiang Li et al.   TETRAHEDRON

Synthesis of isoquinolones via Rh-catalyzed C–H activation of substituted benzamides using air as the sole oxidant in water

(2017) Nitinkumar Satyadev Upadhyay et al.   GREEN CHEMISTRY

Nickel(II)-Catalyzed Site-Selective C–H Bond Trifluoromethylation of Arylamine in Water through a Coordinating Activation Strategy

(2017) Jun Xu et al.   ORGANIC LETTERS

Pd(II)-catalyzed monoarylation of 2-phenylpyridine N-oxide with iodobenzene in water

(2017) Wei Zhang et al.   SYNTHETIC COMMUNICATIONS

Beyond C2 and C3: Transition-Metal-Catalyzed C–H Functionalization of Indole

(2017) Jamie A. Leitch et al.   ACS Catalysis

Palladium-Catalyzed Mono-SelectiveorthoCH Arylation of Aryl Sulfonamides in Water: A Concise Access to Biaryl Sulfoamide Derivatives

(2016) Wei Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Rhodium-Catalyzed Regioselective Synthesis of Isoindolium Salts from 2-Arylpyridines and Alkenes in Aqueous Medium under Oxygen

(2016) Nitinkumar Satyadev Upadhyay et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper(II)-Catalyzed Nitroaldol (Henry) Reactions: Recent Developments

(2016) Govindarasu Murugavel et al.   CHEMICAL RECORD

Transition-Metal-Catalyzed C–H Bond Addition to Carbonyls, Imines, and Related Polarized π Bonds

(2016) Joshua R. Hummel et al.   CHEMICAL REVIEWS

Mild metal-catalyzed C–H activation: examples and concepts

(2016) T. Gensch et al.   CHEMICAL SOCIETY REVIEWS

C−H Bond Activation/Arylation Catalyzed by Arene-Ruthenium-Aniline Complexes in Water

(2016) Chinky Binnani et al.   Chemistry-An Asian Journal

Regioselectiveortho-Acylation ofN-Aryl-1,2,3-triazoles with Alcohols in Water

(2016) Chanchal Premi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Pd(ii) pincer type complex catalyzed tandem C–H and N–H activation of acetanilide in aqueous media: a concise access to functionalized carbazoles in a single step

(2016) Vignesh Arumugam et al.   GREEN CHEMISTRY

“On Water” C(sp3)–H Functionalization/C–O/C–N Bonds Formations: Synthesis of Functionalized Oxazolidines and Imidazolidines

(2016) Vanaparthi Satheesh et al.   JOURNAL OF ORGANIC CHEMISTRY

Recyclable Pd(II)complex catalyzed oxidative sp2 CH bond acylation of 2-aryl pyridines with toluene derivatives

(2016) Pullaiah C. Perumgani et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Palladium-catalysed directed C–H activation by anilides and ureas; water participation in a general base mechanism

(2016) Waqar Rauf et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rhodium-Catalyzed Selective Mono- and Diamination of Arenes with Single Directing Site “On Water”

(2016) Md Ashif Ali et al.   ORGANIC LETTERS

Tandem Rh(III)-Catalyzed C–H Amination/Annulation Reactions: Synthesis of Indoloquinoline Derivatives in Water

(2016) Liangliang Shi et al.   ORGANIC LETTERS

Cp*Co(III)-Catalyzed C(sp3)–H Bond Activation: A Highly Stereoselective and Regioselective Alkenylation of 8-Methylquinoline with Alkynes

(2016) Malay Sen et al.   ACS Catalysis

Evaluation of some quinoline-based hydrazone derivatives as insecticidal agents

(2016) Xiang Yu et al.   RSC Advances

Rhodium(I)-Catalyzed Regiospecific Dimerization of Aromatic Acids: Two Direct CH Bond Activations in Water

(2015) Hang Gong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quinoline-based antimalarial hybrid compounds

(2015) Stéphanie Vandekerckhove et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ru(ii)-catalyzed amidation reactions of 8-methylquinolines with azides via C(sp3)–H activation

(2015) Bingxian Liu et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Construction of Heteroatom-Containing π-Conjugated Systems by Intramolecular Oxidative CH/CH Coupling Reaction

(2015) Kenta Saito et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed C-H Bond Acylation of Acetanilides with Benzylic Alcohols under Aqueous Conditions

(2015) Feihua Luo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Oxidative Directortho-C-H Acylation of Arenes with Aldehydes under Aqueous Conditions

(2015) Fuhong Xiao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

[RhCp*Cl2]2-Catalyzed Directed N-Boc Amidation of Arenes “on Water”

(2015) Md Ashif Ali et al.   ORGANIC LETTERS

A mild and efficient carboxylate-directed C–H arylation of aryl carboxylic acids with iodobenzenes in water

(2015) Zhongmiao Xu et al.   TETRAHEDRON LETTERS

Efficient Palladium-Catalyzed Direct C−H Phenylselenylation of (Hetero)Arenes in Water

(2015) Weiwei Jin et al.   Asian Journal of Organic Chemistry

Highly Efficient “On Water” Catalyst-Free Nucleophilic Addition Reactions Using Difluoroenoxysilanes: Dramatic Fluorine Effects

(2014) Jin-Sheng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(III)-Catalyzed Alkenylation Reactions of 8-Methylquinolines with Alkynes by C(sp3)H Activation

(2014) Bingxian Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-Catalyzed Hydroaroylation of Styrenes in Water through Directed CH Bond Activation

(2014) Anis Tlili et al.   ChemCatChem

Rh(iii)-catalyzed synthesis of 1-aminoindole derivatives from 2-acetyl-1-arylhydrazines and diazo compounds in water

(2014) Yujie Liang et al.   CHEMICAL COMMUNICATIONS

Rhodium(III)-Catalyzed One-Pot Access to Isoquinolines and Heterocycle-Fused Pyridines in Aqueous Medium through C-H Cleavage

(2014) Jitan Zhang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iridium-Catalyzed Intermolecular Amidation of sp3 C–H Bonds: Late-Stage Functionalization of an Unactivated Methyl Group

(2014) Taek Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Substituted Hydroxylamines as Synthetically Versatile Amino Sources in the Iridium-Catalyzed Mild C–H Amidation Reaction

(2014) Pitambar Patel et al.   ORGANIC LETTERS

Sequential Ruthenium(II)-Acetate Catalyzed C–H Bond Diarylation in NMP or Water and Hydrosilylation of Imines

(2014) Bin Li et al.   TOPICS IN CATALYSIS

Mild Palladium-Catalyzed Oxidative Directortho-CH Acylation of Anilides under Aqueous Conditions

(2013) Fruzsina Szabó et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed Direct Functionalization of 2-Aminobutanoic Acid Derivatives: Application of a Convenient and Versatile Auxiliary

(2013) Mengyang Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-Catalyzed Carbonylative CC Coupling in Water by Directed CH Bond Activation

(2013) Anis Tlili et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed CHorthoArylation of Benzoic Acids with Diaryliodonium Salts in Water

(2013) Zhiqing Wu et al.   ChemCatChem

One-pot direct C–H arylation of arenes in water catalysed by RuCl3·nH2O–NaOAc in the presence of Zn

(2013) Luis A. Adrio et al.   CHEMICAL COMMUNICATIONS

CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group

(2013) Shangjun Cai et al.   CHEMICAL COMMUNICATIONS

Palladium-catalyzed para-selective arylation of phenols with aryl iodides in water

(2013) Zhiqing Wu et al.   CHEMICAL COMMUNICATIONS

sp2 C–H bond activation in water and catalytic cross-coupling reactions

(2013) Bin Li et al.   CHEMICAL SOCIETY REVIEWS

Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

(2013) Manoj B. Gawande et al.   CHEMICAL SOCIETY REVIEWS

Hydrogen-Bond-Assisted Controlled C–H Functionalization via Adaptive Recognition of a Purine Directing Group

(2013) Hyun Jin Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh[III]-Catalyzed C–H Amidation Using Aroyloxycarbamates To Give N-Boc Protected Arylamines

(2013) Christoph Grohmann et al.   ORGANIC LETTERS

Diazo Compounds and N-Tosylhydrazones: Novel Cross-Coupling Partners in Transition-Metal-Catalyzed Reactions

(2012) Qing Xiao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Investigation of “On Water” Conditions Using a Biphasic Fluidic Platform

(2012) Sonia Mellouli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

“On Water”: Efficient Iron-Catalyzed Cycloaddition of Aziridines with Heterocumulenes

(2012) Mani Sengoden et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Beyond Directing Groups: Transition-Metal-Catalyzed CH Activation of Simple Arenes

(2012) Nadine Kuhl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization

(2012) Percia Beatrice Arockiam et al.   CHEMICAL REVIEWS

Ruthenium(ii)-catalyzed selective monoarylation in water and sequential functionalisations of C–H bonds

(2012) Percia B. Arockiam et al.   GREEN CHEMISTRY

Palladium-Catalyzed Trifluoromethylation of Aromatic C–H Bond Directed by an Acetamino Group

(2012) Li-Sheng Zhang et al.   ORGANIC LETTERS

Copper-Catalyzed sp3 C–H Amination

(2012) Raymond T. Gephart et al.   ORGANOMETALLICS

Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

(2011) Keary M. Engle et al.   ACCOUNTS OF CHEMICAL RESEARCH

Copper-Catalyzed Aerobic Oxidative CH Functionalizations: Trends and Mechanistic Insights

(2011) Alison E. Wendlandt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation

(2011) Seung Hwan Cho et al.   CHEMICAL SOCIETY REVIEWS

Green chemistry oriented organic synthesis in water

(2011) Marc-Olivier Simon et al.   CHEMICAL SOCIETY REVIEWS

Design and Discovery of a Selective Small Molecule κ Opioid Antagonist (2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242)

(2011) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

CH Bond Functionalization in Water Catalyzed by Carboxylato Ruthenium(II) Systems

(2010) Percia B. Arockiam et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”

(2010) Richard N. Butler et al.   CHEMICAL REVIEWS

Cationic Pd(II)-Catalyzed Fujiwara−Moritani Reactions at Room Temperature in Water

(2010) Takashi Nishikata et al.   ORGANIC LETTERS

Pd-CatalyzedOrtho-C−H Acylation/Cross Coupling of Aryl KetoneO-Methyl Oximes with Aldehydes Usingtert-Butyl Hydroperoxide as Oxidant

(2010) Chun-Wo Chan et al.   ORGANIC LETTERS

Room Temperature CH Activation and Cross-Coupling of Aryl Ureas in Water

(2009) Takashi Nishikata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Secondary Alkyl Halides in Transition-Metal-Catalyzed Cross-Coupling Reactions

(2009) Alena Rudolph et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organic Synthesis “On Water”

(2009) Arani Chanda et al.   CHEMICAL REVIEWS

Construction of Nitrogen-Containing Heterocycles by CH Bond Functionalization

(2009) Praew Thansandote et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed Acylation of sp2C−H bond: Direct Access to Ketones from Aldehydes

(2009) Xiaofei Jia et al.   ORGANIC LETTERS

Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates

(2009) Jérôme Canivet et al.   ORGANIC LETTERS

Synthesis, Structure, and Application of Self-Assembled Copper(II) Aqua Complex by H-Bonding for Acceleration of the Nitroaldol Reaction on Water

(2008) Suribabu Jammi et al.   Chemistry-An Asian Journal

Vanadium(I) Chloride and Lithium Vanadium(I) Dihydride as Selective Epimetallating Reagents for π- and σ-Bonded Organic Substrates

(2008) John J. Eisch et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT

More than Bystanders: The Effect of Olefins on Transition-Metal-Catalyzed Cross-Coupling Reactions

(2007) Jeffrey B. Johnson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION