Recent Advances in Metal‐catalyzed Alkylation, Alkenylation and Alkynylation of Indole/indoline Benzenoid Nucleus

Site-Selective Rh-Catalyzed C-7 and C-6 Dual C–H Functionalization of Indolines: Synthesis of Functionalized Pyrrolocarbazoles

(2020) Sonbidya Banerjee et al.   JOURNAL OF ORGANIC CHEMISTRY

Chromium(III)-Catalyzed C(sp2)–H Alkynylation, Allylation, and Naphthalenation of Secondary Amides with Trimethylaluminum as Base

(2020) Mengqing Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Weak Coordination Enabled Switchable C4-Alkenylation and Alkylation of Indoles with Allyl Alcohols

(2020) Sourav Pradhan et al.   ORGANIC LETTERS

Aerobic Oxidative Functionalization of Indoles

(2020) Saiwen Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Cp*Co(III)-Catalyzed C-7 C–C Coupling of Indolines with Aziridines: Merging C–H Activation and Ring Opening

(2020) Pinaki Bhusan De et al.   JOURNAL OF ORGANIC CHEMISTRY

Weak Coordinating Carbonyl-Directed Rhodium(III)-Catalyzed C–H Activation at the C4-Position of Indole with Allyl Alcohols

(2020) Mahadev Sharanappa Sherikar et al.   JOURNAL OF ORGANIC CHEMISTRY

Cobalt-Catalyzed One-Step Access to Pyroquilon and C-7 Alkenylation of Indoline with Activated Alkenes Using Weakly Coordinating Functional Groups

(2020) Shyam Kumar Banjare et al.   JOURNAL OF ORGANIC CHEMISTRY

Thioether-Directed C4-Selective C–H Acylmethylation of Indoles Using α-Carbonyl Sulfoxonium Ylides

(2020) Chandrababu Naidu Kona et al.   ORGANIC LETTERS

C7‐Indole Amidations and Alkenylations by Ruthenium(II) Catalysis

(2020) Isaac Choi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed C(sp2)–H Alkylation of Indolines and Benzo[h]quinoline with Unactivated Alkyl Chlorides through Chelation Assistance

(2020) Rahul A. Jagtap et al.   ACS Catalysis

Palladium Catalyzed Site-Selective C4-Arylation and Olefination of Indoles and Azaindoles

(2019) Thrimurtulu Neetipalli et al.   ADVANCED SYNTHESIS & CATALYSIS

RuII -Catalysed Regioselective C-N Bond Formation of Indolines and Carbazole with Acyl Azides

(2019) Sonbidya Banerjee et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Pentacyclic (−)-Ambiguine P Using Sequential Indole Functionalizations

(2019) Rebecca E. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Direct C4- and C7-Selective Alkynylation of Indoles Using Sulfur-Directing Groups

(2019) Masahiro Miura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed Selective C–H Trideuteromethylation of Indole at C7 Position Using Acetic-d6 Anhydride

(2019) Xiaowei Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Ga(OTf)3-Catalyzed Temperature-Controlled Regioselective Friedel–Crafts Alkylation of Trifluoromethylated 3-Indolylmethanols with 2-Substituted Indoles: Divergent Synthesis of Trifluoromethylated Unsymmetrical 3,3′-and 3,6′-Bis(indolyl)methanes

(2019) Yuan Ling et al.   ORGANIC LETTERS

Cobalt Catalyzed Hydroarylation of Michael Acceptors with Indolines Directed by a Weakly Coordinating Functional Group

(2019) Shyam Kumar Banjare et al.   ORGANIC LETTERS

C2/C4 Regioselective Heteroarylation of Indoles by Tuning C–H Metalation Modes

(2019) Shuyou Chen et al.   ACS Catalysis

Exploiting Strained Rings in Chelation Guided C‐H Functionalization: Integration of C‐H Activation with Ring Cleavage

(2019) Tharmalingam Punniyamurthy et al.   Chemistry-An Asian Journal

Iron-Catalyzed Regioselective Remote C(sp2)-H Carboxylation of Naphthyl and Quinoline Amides

(2019) Sandeep Kumar et al.   JOURNAL OF ORGANIC CHEMISTRY

Cobalt-Catalyzed Regioselective Direct C-4 Alkenylation of 3-Acetylindole with Michael Acceptors Using a Weakly Coordinating Functional Group

(2019) Shyam Kumar Banjare et al.   ORGANIC LETTERS

Cp*Co(III)-Catalyzed Regioselective C2 Amidation of Indoles Using Acyl Azides

(2019) Tariq A. Shah et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective C–H Olefination of Indolines (C5) and Tetrahydroquinolines (C6) by Pd/S,O-Ligand Catalysis

(2019) Wen-Liang Jia et al.   ORGANIC LETTERS

Weak Coordination-Guided Regioselective Direct Redox-Neutral C4 Allylation of Indoles with Morita–Baylis–Hillman Adducts

(2019) Sourav Pradhan et al.   ORGANIC LETTERS

C−H Functionalization of Indoles by 3d Transition‐Metal Catalysis

(2019) Rahul A. Jagtap et al.   Asian Journal of Organic Chemistry

Expedient cobalt(ii)-catalyzed site-selective C7-arylation of indolines with arylboronic acids

(2018) Pinaki Bhusan De et al.   CHEMICAL COMMUNICATIONS

Copper-mediated regioselective C–H etherification of naphthylamides with arylboronic acids using water as an oxygen source

(2018) Subhasish Roy et al.   CHEMICAL COMMUNICATIONS

Regioselective direct arylation of indoles on the benzenoid moiety

(2018) Youqing Yang et al.   CHEMICAL COMMUNICATIONS

Remote C−H Activation of Various N-Heterocycles Using a Single Template

(2018) Guoqiang Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rhodium-catalyzed oxidative homologation of N -pyrimidyl indolines with alkynes via dual C H activation: Facile synthesis of benzo[ g ]indolines

(2018) Lianhui Wang et al.   CHINESE CHEMICAL LETTERS

Rhodium(III)-Catalyzed Regioselective Direct C4-Alkylation and C2-Annulation of Indoles: Straightforward Access to Indolopyridone

(2018) Aniruddha Biswas et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Weak Directing Group Steered Formal Oxidative [2+2+2]-Cyclization for Selective Benzannulation of Indoles

(2018) Kiran R. Bettadapur et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium(III)-Catalyzed Oxidative Coupling of N-Phenylindole-3-carboxylic Acids with Alkenes and Alkynes via C4–H and C2–H/C2′–H Bond Cleavage

(2018) Takeshi Okada et al.   JOURNAL OF ORGANIC CHEMISTRY

Access to C5-Alkylated Indolines/Indoles via Michael-Type Friedel–Crafts Alkylation Using Aryl-Nitroolefins

(2018) Berrak Ertugrul et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed, Remote Terminal Hydroarylation of Activated Olefins through a Long-Range Deconjugative Isomerization

(2018) Arun Jyoti Borah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium-catalyzed C7-alkylation of indolines with maleimides

(2018) Changduo Pan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles

(2018) Wenzheng Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

C4–H indole functionalisation: precedent and prospects

(2018) Jagadeesh Kalepu et al.   Chemical Science

Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives

(2018) Chunchen Yuan et al.   Nature Communications

Beyond Friedel and Crafts: Directed Alkylation of C-H Bonds in Arenes

(2018) Gwilherm Evano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(iii)-catalyzed C–H activation at the C4-position of indole: switchable hydroarylation and oxidative Heck-type reactions of maleimides

(2018) Mahadev Sharanappa Sherikar et al.   CHEMICAL COMMUNICATIONS

Ru(ii)-Catalyzed C7-acyloxylation of indolines with carboxylic acids

(2018) Pinaki Bhusan De et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Thioether-Directed Selective C4 C–H Alkenylation of Indoles under Rhodium Catalysis

(2018) Chandrababu Naidu Kona et al.   ORGANIC LETTERS

Rhodium(III)-Catalyzed Direct C7 Allylation of Indolines via Sequential C-H and C-C Activation

(2018) Qiuling Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

PIII -Chelation-Assisted Indole C7-Arylation, Olefination, Methylation, and Acylation with Carboxylic Acids/Anhydrides by Rhodium Catalysis

(2018) Xiaodong Qiu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RhIII-Catalyzed CF3-Carbenoid C-7 Functionalization of Indolines

(2017) Irina E. Iagafarova et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Regioselective C–H Bond Alkynylation of Carbonyl Compounds through Ir(III) Catalysis

(2017) Xianwei Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper(II)-Mediated Chelation-Assisted Regioselective N-Naphthylation of Indoles, Pyrazoles and Pyrrole through Dehydrogenative Cross-Coupling

(2017) Sourav Pradhan et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper(II)-Catalyzed Oxidative Coupling of Anilines, Methyl Arenes, and TMSN3 via C(sp3/sp2)–H Functionalization and C–N Bond Formation

(2017) Devulapally Mahesh et al.   ORGANIC LETTERS

Regioselective Direct C-4 Functionalization of Indole: Total Syntheses of (−)-Agroclavine and (−)-Elymoclavine

(2017) Jianbo Lv et al.   ORGANIC LETTERS

Rhodium-Catalyzed Site-Selective Coupling of Indoles with Diazo Esters: C4-Alkylation versus C2-Annulation

(2017) Xiaohong Chen et al.   ORGANIC LETTERS

Rh(III)-catalyzed C−H alkylation of indolines with enones through conjugate addition and protonation pathway

(2017) Hyunjung Oh et al.   TETRAHEDRON

Remote C6-Selective Ruthenium-Catalyzed C–H Alkylation of Indole Derivatives via σ-Activation

(2017) Jamie A. Leitch et al.   ACS Catalysis

Beyond C2 and C3: Transition-Metal-Catalyzed C–H Functionalization of Indole

(2017) Jamie A. Leitch et al.   ACS Catalysis

One-pot synthesis of fluorescent 2,4-dialkenylindoles by rhodium-catalyzed dual C–H functionalization

(2017) Hui Chen et al.   Organic Chemistry Frontiers

Copper(ii)-mediated regioselective N-arylation of pyrroles, indoles, pyrazoles and carbazole via dehydrogenative coupling

(2016) Pradeep Sadhu et al.   CHEMICAL COMMUNICATIONS

Alkenylation of Arenes and Heteroarenes with Alkynes

(2016) Vadim P. Boyarskiy et al.   CHEMICAL REVIEWS

Rhodium(III)-Catalyzed Mild Alkylation of (Hetero)Arenes with Cyclopropanols via C–H Activation and Ring Opening

(2016) Xukai Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed C–H Arylation of Indoles at the C7 Position

(2016) Youqing Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh(III)-Catalyzed Carbocyclization of 3-(Indolin-1-yl)-3-oxopropanenitriles with Alkynes and Alkenes through C–H Activation

(2016) Tao Zhou et al.   ORGANIC LETTERS

Electronic Nature of Ketone Directing Group as a Key To Control C-2 vs C-4 Alkenylation of Indoles

(2016) Veeranjaneyulu Lanke et al.   ORGANIC LETTERS

Rh(III)-Catalyzed Aryl and Alkenyl C–H Bond Addition to Diverse Nitroalkenes

(2016) Tyler J. Potter et al.   ACS Catalysis

Ru-Catalyzed selective C–H oxidative olefination with N-heteroarenes directed by pivaloyl amide

(2016) Li Zhang et al.   Organic Chemistry Frontiers

Transition Metal-Catalyzed CH Activation of Indoles

(2015) Alexander H. Sandtorv   ADVANCED SYNTHESIS & CATALYSIS

Rhodium-Catalyzed Regioselective C7-Functionalization of N -Pivaloylindoles

(2015) Lanting Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(iii)-catalyzed C7-position C–H alkenylation and alkynylation of indolines

(2015) Xiao-Fei Yang et al.   CHEMICAL COMMUNICATIONS

A review on recent developments of indole-containing antiviral agents

(2015) Ming-Zhi Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rhodium-Catalyzed C–H Alkylation of Indolines with Allylic Alcohols: Direct Access to β-Aryl Carbonyl Compounds

(2015) Sang Hoon Han et al.   JOURNAL OF ORGANIC CHEMISTRY

Mild Rh(III)-Catalyzed C7-Allylation of Indolines with Allylic Carbonates

(2015) Jihye Park et al.   JOURNAL OF ORGANIC CHEMISTRY

Access to Six- and Seven-Membered 1,7-Fused Indolines via Rh(III)-Catalyzed Redox-Neutral C7-Selective C–H Functionalization of Indolines with Alkynes and Alkenes

(2015) Xuan Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Ruthenium-catalyzed cyclization of N-carbamoyl indolines with alkynes: an efficient route to pyrroloquinolinones

(2015) Ramasamy Manoharan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Expedient Synthesis of Pyrroloquinolinones by Rh-Catalyzed Annulation of N-Carbamoyl Indolines with Alkynes through a Directed C–H Functionalization/C–N Cleavage Sequence

(2015) Xiao-Fei Yang et al.   ORGANIC LETTERS

Palladium-Catalyzed Regioselective Decarboxylative Alkylation of Arenes and Heteroarenes with Aliphatic Carboxylic Acids

(2015) Chanchal Premi et al.   ORGANIC LETTERS

Sequential one-pot Rh(III)-catalyzed direct C2 and C7 alkylation of (hetero)aromatic C–H bonds of indoles

(2015) Liang Wang et al.   TETRAHEDRON LETTERS

Iridium(I)-Catalyzed Direct CH Bond Alkylation of the C-7 Position of Indolines with Alkenes

(2014) Shiguang Pan et al.   ADVANCED SYNTHESIS & CATALYSIS

Rhodium(iii)-catalyzed C2-selective carbenoid functionalization and subsequent C7-alkenylation of indoles

(2014) Jingjing Shi et al.   CHEMICAL COMMUNICATIONS

Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds

(2014) Wen Ai  et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ir(III)-Catalyzed C7-Position-Selective Oxidative CH Alkenylation of Indolines with Alkenes in Air

(2014) Shiguang Pan et al.   Chemistry-An Asian Journal

Rings in Drugs

(2014) Richard D. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic C6 Functionalization of 2,3-Disubstituted Indoles by Scandium Triflate

(2014) Hua Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd(II)-Catalyzed meta-C–H Olefination, Arylation, and Acetoxylation of Indolines Using a U-Shaped Template

(2014) Guoqiang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unexpected regioselective carbon–hydrogen bond activation/cyclization of indolyl aldehydes or ketones with alkynes to benzo-fused oxindoles

(2014) Xingyan Liu et al.   Nature Communications

The Witkop Cyclization: A Photoinduced CH Activation of the Indole System

(2013) Philipp J. Gritsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidative Palladium(II)-Catalyzed C-7 Alkenylation of Indolines

(2013) Lin-Yu Jiao et al.   ORGANIC LETTERS

Direct Olefination at the C-4 Position of Tryptophan via C–H Activation: Application to Biomimetic Synthesis of Clavicipitic Acid

(2013) Qiang Liu et al.   ORGANIC LETTERS

Rhodium(III)-Catalyzed Direct Regioselective Synthesis of 7-Substituted Indoles

(2013) Zengqiang Song et al.   ORGANIC LETTERS

Regioselective Synthesis of 4-Substituted Indoles via C–H Activation: A Ruthenium Catalyzed Novel Directing Group Strategy

(2013) Veeranjaneyulu Lanke et al.   ORGANIC LETTERS

Catalytic Coupling of Arene C–H Bonds and Alkynes for the Synthesis of Coumarins: Substrate Scope and Application to the Development of Neuroimaging Agents

(2012) Paul A. Vadola et al.   JOURNAL OF ORGANIC CHEMISTRY

Ruthenium-catalyzed direct oxidative alkenylation of arenes through twofold C–H bond functionalization

(2012) Sergei I. Kozhushkov et al.   Chemical Science

Directed Oxidative Cyclizations to C2- or C4-Positions of Indole: Efficient Construction of the Bicyclo[4.3.1]Decane Core of Welwitindolinones

(2011) Vikram Bhat et al.   ORGANIC LETTERS

Indole synthesis: a review and proposed classification

(2011) Douglass F. Taber et al.   TETRAHEDRON

Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety

(2010) Anna J. Kochanowska-Karamyan et al.   CHEMICAL REVIEWS

The Raputindoles: Novel Cyclopentyl Bisindole Alkaloids from Raputia simulans

(2010) Konstantina Vougogiannopoulou et al.   ORGANIC LETTERS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS