Sustainable Ruthenium(II)-Catalyzed C–H Activations in and on H2O

Earth-abundant 3d transition metals on the rise in catalysis

(2022) Nikolaos Kaplaneris et al.   Beilstein Journal of Organic Chemistry

A Perspective on Late-Stage Aromatic C–H Bond Functionalization

(2022) Li Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques

(2022) Maria Chatzopoulou et al.   ACS Medicinal Chemistry Letters

Organic Electrochemistry: Molecular Syntheses with Potential

(2021) Cuiju Zhu et al.   ACS Central Science

Remote C–H Functionalizations by Ruthenium Catalysis

(2021) Korkit Korvorapun et al.   SYNTHESIS-STUTTGART

Organic Synthesis in Aqueous Multiphase Systems - Challenges and Opportunities ahead of Us

(2021) Pascal Hauk et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Late-stage C–H functionalization offers new opportunities in drug discovery

(2021) Lucas Guillemard et al.   Nature Reviews Chemistry

C–H activation by immobilized heterogeneous photocatalysts

(2021) Isaac Choi et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Site-Selective C–H Functionalization via Synergistic Use of Electrochemistry and Transition Metal Catalysis

(2020) Ke-Jin Jiao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bidentate Directing Groups: An Efficient Tool in C–H Bond Functionalization Chemistry for the Expedient Construction of C–C Bonds

(2020) Supriya Rej et al.   CHEMICAL REVIEWS

Reactions in Water through “On‐Water” Mechanism

(2020) Taku Kitanosono et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium(II)-Catalyzed Ortho-C–H Alkylation of Naphthylamines with Diazo Compounds for Synthesis of 2,2-Disubstituted π-Extended 3-Oxindoles in Water

(2020) Xiaogang Wang et al.   ORGANIC LETTERS

Advancing the logic of chemical synthesis: C–H activation as strategic and tactical disconnections for C–C bond construction

(2020) Nelson Yuen Sum Lam et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fundamentals, Applications, and Future Directions of Bioelectrocatalysis

(2020) Hui Chen et al.   CHEMICAL REVIEWS

Cross‐Dehydrogenative Coupling/Annulation of Arene Carboxylic Acids and Alkenes in Water with Ruthenium(II) Catalyst and Air

(2020) Anup Mandal et al.   Chemistry-An Asian Journal

Reactivity-Controlling Factors in Carboxylate-Assisted C–H Activation under 4d and 3d Transition Metal Catalysis

(2020) Torben Rogge et al.   ACS Catalysis

Ruthenium(II)‐Catalyzed C‐H Annulation of Aromatic Acids with Alkynes Using Air as the Sole Oxidant in Water

(2020) Jiaping Wu et al.   ChemistrySelect

Regioselective C–H Alkenylation and Unsymmetrical Bis-olefination of Heteroarene Carboxylic Acids with Ruthenium Catalysis in Water

(2020) Anup Mandal et al.   JOURNAL OF ORGANIC CHEMISTRY

Biomass-Derived Solvents for Sustainable Transition Metal-Catalyzed C‒H Activation

(2019) Gandeepan Parthasarathy et al.   ACS Sustainable Chemistry & Engineering

Micellar Catalysis for Ruthenium(II)-Catalyzed C−H Arylation: Weak-Coordination-Enabled C−H Activation in H2O

(2019) Santhivardhana Reddy Yetra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Switchable C−H Alkylation of Aromatic Acids with Maleimides in Water: Carboxyl as a Diverse Directing Group

(2019) Fan Pu et al.   ChemCatChem

Hydrophilic (η6-Arene)–Ruthenium(II) Complexes with P–OH Ligands as Catalysts for the Isomerization of Allylbenzenes and C–H Bond Arylation Reactions in Water

(2019) Rebeca González-Fernández et al.   ORGANOMETALLICS

Electrochemical Oxidative Cross-Coupling with Hydrogen Evolution Reactions

(2019) Yong Yuan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Arene-Free Ruthenium(II/IV)-Catalyzed Bifurcated Arylation for Oxidative C−H/C−H Functionalizations

(2019) Torben Rogge et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis

(2019) Alexandra Schischko et al.   Nature Communications

Ruthenium(II)‐Catalyzed C−H Bond [3+2] Annulation of N ‐Nitrosoanilines with Alkynes in Water

(2019) Xun Chen et al.   Asian Journal of Organic Chemistry

Metalla-electrocatalyzed C–H Activation by Earth-Abundant 3d Metals and Beyond

(2019) Lutz Ackermann   ACCOUNTS OF CHEMICAL RESEARCH

Late-Stage Peptide Diversification by Position-Selective C-H Activation

(2018) Wei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrooxidative Ruthenium-Catalyzed C−H/O−H Annulation by Weak O -Coordination

(2018) Youai Qiu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Green and Sustainable Solvents in Chemical Processes

(2018) Coby J. Clarke et al.   CHEMICAL REVIEWS

Regioselective C−H Alkylation via Carboxylate-Directed Hydroarylation in Water

(2018) Guodong Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Hydrophobic Effect Applied to Organic Synthesis: Recent Synthetic Chemistry “in Water”

(2018) Bruce H. Lipshutz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium(ii) oxidase catalysis for C–H alkenylations in biomass-derived γ-valerolactone

(2018) Alexander Bechtoldt et al.   GREEN CHEMISTRY

Controlled mono-olefination versus diolefination of arenes via C–H activation in water: a key role of catalysts

(2018) Hailong Zhang et al.   GREEN CHEMISTRY

Recent advances in mechanochemical C–H functionalization reactions

(2018) Shujuan Zhao et al.   TETRAHEDRON LETTERS

Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

(2018) Joseph L. Howard et al.   Chemical Science

Sequential meta-/ortho-C–H Functionalizations by One-Pot Ruthenium(II/III) Catalysis

(2018) Korkit Korvorapun et al.   ACS Catalysis

Electrocatalytic C–H Activation

(2018) Nicolas Sauermann et al.   ACS Catalysis

Ruthenium-Catalyzed Intramolecular Hydroarylation of Arenes with Olefins in Water

(2018) Kallol Mukherjee et al.   Asian Journal of Organic Chemistry

Carboxyl-Directed Conjugate Addition of C−H Bonds to α ,β -Unsaturated Ketones in Air and Water

(2018) Wen-Jing Han et al.   ADVANCED SYNTHESIS & CATALYSIS

A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

(2018) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

Arene Ruthenium Catalyst MCAT-53 for the Synthesis of Heterobiaryl Compounds in Water through Aromatic C–H Bond Activation

(2018) Anita Mehta et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Game of Directors: Accessing Remote Meta- and Para-C--H Bonds With Covalently Attached Directing Groups

(2018) Aniruddha Dey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3d Transition Metals for C–H Activation

(2018) Parthasarathy Gandeepan et al.   CHEMICAL REVIEWS

Ruthenium(II)-Catalyzed Direct C–H Arylation of Indoles with Arylsilanes in Water

(2017) Pradeep Nareddy et al.   ORGANIC LETTERS

Ru-catalyzed ortho -oxidative alkenylation of 2-arylbenzo[ d ]thiazoles in aqueous solution of anionic surfactant sodium dodecylbenzenesulfonate (SDBS)

(2017) Yuanyuan Ping et al.   TETRAHEDRON

The merger of transition metal and photocatalysis

(2017) Jack Twilton et al.   Nature Reviews Chemistry

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis

(2016) Markus D. Kärkäs et al.   CHEMICAL REVIEWS

Organic Photoredox Catalysis

(2016) Nathan A. Romero et al.   CHEMICAL REVIEWS

Direct (Hetero)arylation Polymerization: Simplicity for Conjugated Polymer Synthesis

(2016) Jean-Rémi Pouliot et al.   CHEMICAL REVIEWS

Mild metal-catalyzed C–H activation: examples and concepts

(2016) T. Gensch et al.   CHEMICAL SOCIETY REVIEWS

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

C−H Bond Activation/Arylation Catalyzed by Arene-Ruthenium-Aniline Complexes in Water

(2016) Chinky Binnani et al.   Chemistry-An Asian Journal

Heterogeneous catalytic approaches in C–H activation reactions

(2016) Stefano Santoro et al.   GREEN CHEMISTRY

A New Catalytic System for Ru-Catalyzed C–H Arylation Reactions and Its Application in the Practical Syntheses of Pharmaceutical Agents

(2016) Masahiko Seki   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities

(2016) John F. Hartwig et al.   ACS Central Science

Iron-Catalyzed C–H Functionalization Processes

(2016) Gianpiero Cera et al.   Topics in Current Chemistry

Bidentate, Monoanionic Auxiliary-Directed Functionalization of Carbon–Hydrogen Bonds

(2015) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Ruthenium Oxidase Catalysis for Site-Selective C-H Alkenylations with Ambient O2 as the Sole Oxidant

(2015) Alexander Bechtoldt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single-Component Phosphinous Acid Ruthenium(II) Catalysts for Versatile C−H Activation by Metal-Ligand Cooperation

(2015) Daniel Zell et al.   CHEMISTRY-A EUROPEAN JOURNAL

Robust Ruthenium(II)-Catalyzed C–H Arylations: Carboxylate Assistance for the Efficient Synthesis of Angiotensin-II-Receptor Blockers

(2015) Lutz Ackermann   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Cobalt-Catalyzed C–H Activation

(2015) Marc Moselage et al.   ACS Catalysis

Carboxylate-assisted ruthenium(ii)-catalyzed C–H activations of monodentate amides with conjugated alkenes

(2015) Jie Li et al.   Organic Chemistry Frontiers

Low-Valent Cobalt Catalysis: New Opportunities for C–H Functionalization

(2014) Ke Gao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Carboxylate-Assisted Ruthenium-Catalyzed Alkyne Annulations by C–H/Het–H Bond Functionalizations

(2013) Lutz Ackermann   ACCOUNTS OF CHEMICAL RESEARCH

On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors

(2013) Bruce H. Lipshutz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct CH bond Arylation in Water Promoted by (O,O)- and (O,N)-Chelate Ruthenium(II) Catalysts

(2013) Keisham S. Singh et al.   ChemCatChem

One-pot direct C–H arylation of arenes in water catalysed by RuCl3·nH2O–NaOAc in the presence of Zn

(2013) Luis A. Adrio et al.   CHEMICAL COMMUNICATIONS

Sanofi’s Solvent Selection Guide: A Step Toward More Sustainable Processes

(2013) Denis Prat et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Metal-Catalyzed Nitrogen-Atom Transfer Methods for the Oxidation of Aliphatic C–H Bonds

(2012) Jennifer L. Roizen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis and Application of Water-Soluble NHC Transition-Metal Complexes

(2012) Lars-Arne Schaper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Cross-Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize

(2012) Carin C. C. Johansson Seechurn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization

(2012) Percia Beatrice Arockiam et al.   CHEMICAL REVIEWS

Ruthenium(ii)-catalyzed selective monoarylation in water and sequential functionalisations of C–H bonds

(2012) Percia B. Arockiam et al.   GREEN CHEMISTRY

Ruthenium-Catalyzed Oxidative C–H Alkenylations of Anilides and Benzamides in Water

(2012) Lutz Ackermann et al.   ORGANIC LETTERS

Well-Defined Ruthenium(II) Carboxylate as Catalyst for Direct C–H/C–O Bond Arylations with Phenols in Water

(2012) Lutz Ackermann et al.   ORGANIC LETTERS

Cationic Ruthenium(II) Catalysts for Oxidative C–H/N–H Bond Functionalizations of Anilines with Removable Directing Group: Synthesis of Indoles in Water

(2012) Lutz Ackermann et al.   ORGANIC LETTERS

Catalytic C–H bond arylation of aryl imines and oxazolines in water with ruthenium(II)-acetate catalyst

(2012) Bin Li et al.   TETRAHEDRON

Metal Impurities Cause False Positives in High-Throughput Screening Campaigns

(2012) Johannes C. Hermann et al.   ACS Medicinal Chemistry Letters

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

Direct Arylation as a Synthetic Tool for the Synthesis of Thiophene-Based Organic Electronic Materials

(2011) Derek J. Schipper et al.   CHEMISTRY OF MATERIALS

Preparative Scale Synthesis of the Biaryl Core of Anacetrapib via a Ruthenium-Catalyzed Direct Arylation Reaction: Unexpected Effect of Solvent Impurity on the Arylation Reaction†

(2011) Stéphane G. Ouellet et al.   JOURNAL OF ORGANIC CHEMISTRY

Ruthenium-Catalyzed Oxidative C–H Bond Alkenylations in Water: Expedient Synthesis of Annulated Lactones

(2011) Lutz Ackermann et al.   ORGANIC LETTERS

Ruthenium-Catalyzed C–H/N–O Bond Functionalization: Green Isoquinolone Syntheses in Water

(2011) Lutz Ackermann et al.   ORGANIC LETTERS

Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes

(2011) Concepcion Jimenez-Gonzalez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

CH Bond Functionalization in Water Catalyzed by Carboxylato Ruthenium(II) Systems

(2010) Percia B. Arockiam et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition-Metal-Catalyzed Regioselective Arylation and Vinylation of Carboxylic Acids

(2010) Tetsuya Satoh et al.   SYNTHESIS-STUTTGART

Ruthenium(II) Acetate Catalyst for Direct Functionalisation of sp2-CH Bonds with Aryl Chlorides and Access to Tris- Heterocyclic Molecules

(2009) Franc Požgan et al.   ADVANCED SYNTHESIS & CATALYSIS

Transition-Metal-Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

(2009) Lutz Ackermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organic Synthesis “On Water”

(2009) Arani Chanda et al.   CHEMICAL REVIEWS

Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

(2009) Denise A. Colby et al.   CHEMICAL REVIEWS

Assisted Ruthenium-Catalyzed C−H Bond Activation: Carboxylic Acids as Cocatalysts for Generally Applicable Direct Arylations in Apolar Solvents

(2008) Lutz Ackermann et al.   ORGANIC LETTERS

[RuCl3(H2O)n]-catalyzed direct arylations

(2008) Lutz Ackermann et al.   TETRAHEDRON