BDNF and Lactate as Modulators of Hippocampal CA3 Network Physiology

NMDA receptor activity during postnatal development determines intrinsic excitability and mossy fiber long‐term potentiation of CA3 pyramidal cells

(2023) Luis A. Márquez et al.   HIPPOCAMPUS

Exogenous lactate augments exercise-induced improvement in memory but not in hippocampal neurogenesis

(2023) Deunsol Hwang et al.   Scientific Reports

Lactate as a determinant of neuronal excitability, neuroenergetics and beyond

(2023) Bruno Cauli et al.   NEUROBIOLOGY OF DISEASE

Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminals

(2022) Hannah R. Monday et al.   NEURON

Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations

(2022) Martina Sgritta et al.   iScience

Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain

(2021) Maksim Storozhuka et al.   Current Neuropharmacology

Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

(2021) Pablo J Lituma et al.   eLife

Astrocyte control of the entorhinal cortex‐dentate gyrus circuit: Relevance to cognitive processing and impairment in pathology

(2021) Maria Amalia Di Castro et al.   GLIA

Lactate ions induce synaptic plasticity to enhance output from the central respiratory network

(2021) Nikolaus Bueschke et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabotropic Glutamate Receptors at the Aged Mossy Fiber – CA3 Synapse of the Hippocampus

(2020) Ernesto Griego et al.   NEUROSCIENCE

Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?

(2020) Patrick Müller et al.   Journal of Clinical Medicine

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy

(2020) Sara Fernández-García et al.   Cell Death & Disease

Immature Dentate Granule Cells Require Ntrk2/Trkb for the Formation of Functional Hippocampal Circuitry

(2020) Sylvia Badurek et al.   iScience

The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease

(2020) Meysam Amidfar et al.   LIFE SCIENCES

Functional expression of TrkB receptors on interneurones and pyramidal cells of area CA3 of the rat hippocampus

(2020) Ernesto Griego et al.   NEUROPHARMACOLOGY

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

(2019) Lauretta El Hayek et al.   JOURNAL OF NEUROSCIENCE

The lactate receptor HCAR1 modulates neuronal network activity through the activation of Gα and Gβɣ subunits

(2019) Haíssa de Castro Abrantes et al.   JOURNAL OF NEUROSCIENCE

Exercise and Hippocampal Memory Systems

(2019) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity

(2019) Ana Paula De Vincenti et al.   Frontiers in Cellular Neuroscience

Acid-sensing ion channels (ASICs) influence excitability of stellate neurons in the mouse cochlear nucleus

(2019) Ziya Cakir et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY

Lactate reduces epileptiform activity through HCA1 and GIRK channel activation in rat subicular neurons in an in vitro model

(2019) Pooja Jorwal et al.   EPILEPSIA

BDNF induces in vivo long-lasting enhancement of synaptic transmission and structural reorganization at the hippocampal mossy fibers in a transcription and translation-independent manner

(2019) Araceli Martínez-Moreno et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The contribution of ion channels in input-output plasticity

(2019) Dominique Debanne et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus

(2018) Carolina Tecuatl et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Modulation of hippocampal excitability via the hydroxycarboxylic acid receptor 1

(2018) Gabriel Herrera-López et al.   HIPPOCAMPUS

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation

(2018) Feng-Ju Weng et al.   NEURON

BDNF and TrkB Mediate the Improvement from Chronic Stress-induced Spatial Memory Deficits and CA3 Dendritic Retraction

(2018) J. Bryce Ortiz et al.   NEUROSCIENCE

LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling

(2018) Enhui Pan et al.   JOURNAL OF NEUROPHYSIOLOGY

Function of local circuits in the hippocampal dentate gyrus-CA3 system

(2018) Yuta Senzai   NEUROSCIENCE RESEARCH

L-Lactate Regulates the Expression of Synaptic Plasticity and Neuroprotection Genes in Cortical Neurons: A Transcriptome Analysis

(2018) Michael B. Margineanu et al.   Frontiers in Molecular Neuroscience

Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding

(2017) Nelson Rebola et al.   NATURE REVIEWS NEUROSCIENCE

CaMKII requirement for the persistence of in vivo hippocampal mossy fiber synaptic plasticity and structural reorganization

(2017) Yectivani Juárez-Muñoz et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance

(2017) Yuki Hashimotodani et al.   NEURON

Neurobiology of local and intercellular BDNF signaling

(2017) Manju Sasi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Lactate as a Metabolite and a Regulator in the Central Nervous System

(2016) Patrizia Proia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain-derived neurotrophic factor differentially modulates excitability of two classes of hippocampal output neurons

(2016) A. R. Graves et al.   JOURNAL OF NEUROPHYSIOLOGY

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

Npas4: Linking Neuronal Activity to Memory

(2016) Xiaochen Sun et al.   TRENDS IN NEUROSCIENCES

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

(2016) Keiichiro Minatohara et al.   Frontiers in Molecular Neuroscience

Regulation of hippocampal synaptic plasticity by BDNF

(2015) Graciano Leal et al.   BRAIN RESEARCH

The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

(2015) Cecilie Morland et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The BDNF Val66Met variant affects gene expression through miR-146b

(2015) Pei-Ken Hsu et al.   NEUROBIOLOGY OF DISEASE

Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons

(2015) E.J. Galván et al.   NEUROSCIENCE

A computational theory of hippocampal function, and tests of the theory: New developments

(2015) Raymond P. Kesner et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mossy fiber mis-pathfinding and semaphorin reduction in the hippocampus of α-CaMKII hKO mice

(2015) Soichiro Nakahara et al.   NEUROSCIENCE LETTERS

Lactate and the injured brain

(2014) Pierre Bouzat et al.   Current Opinion in Critical Care

Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins

(2014) Masaki Takimoto et al.   JOURNAL OF APPLIED PHYSIOLOGY

Information processing and synaptic plasticity at hippocampal mossy fiber terminals

(2014) Alesya Evstratova et al.   Frontiers in Cellular Neuroscience

Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network

(2014) Caroline Le Duigou et al.   Frontiers in Cellular Neuroscience

Lactate-mediated glia-neuronal signalling in the mammalian brain

(2014) F. Tang et al.   Nature Communications

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors

(2013) Mario Carta et al.   EMBO JOURNAL

Acute and chronic interference with BDNF/TrkB-signaling impair LTP selectively at mossy fiber synapses in the CA3 region of mouse hippocampus

(2013) Sandra Schildt et al.   NEUROPHARMACOLOGY

The synaptic plasticity and memory hypothesis: encoding, storage and persistence

(2013) T. Takeuchi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway

(2013) Luigi Bozzo et al.   PLoS One

A process analysis of the CA3 subregion of the hippocampus

(2013) Raymond P. Kesner   Frontiers in Cellular Neuroscience

Involvement of TrkB- and p75NTR-signaling pathways in two contrasting forms of long-lasting synaptic plasticity

(2013) Shigeo Sakuragi et al.   Scientific Reports

Physical Exercise and Antidepressants Enhance BDNF Targeting in Hippocampal CA3 Dendrites: Further Evidence of a Spatial Code for BDNF Splice Variants

(2012) Gabriele Baj et al.   NEUROPSYCHOPHARMACOLOGY

Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice

(2012) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)

(2011) S. Offermanns et al.   PHARMACOLOGICAL REVIEWS

Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation

(2011) K. Ramamoorthi et al.   SCIENCE

In vivo BDNF modulation of hippocampal mossy fiber plasticity induced by high frequency stimulation

(2010) Andrea Gómez-Palacio Schjetnan et al.   HIPPOCAMPUS

Activity-Dependent Release of Endogenous BDNF From Mossy Fibers Evokes a TRPC3 Current and Ca2+ Elevations in CA3 Pyramidal Neurons

(2010) Yong Li et al.   JOURNAL OF NEUROPHYSIOLOGY

Multiple forms of long-term synaptic plasticity at hippocampal mossy fiber synapses on interneurons

(2010) Emilio J. Galván et al.   NEUROPHARMACOLOGY

Exercise and time-dependent benefits to learning and memory

(2010) N.C. Berchtold et al.   NEUROSCIENCE

Blood Lactate is an Important Energy Source for the Human Brain

(2009) Gerrit van Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

Mature BDNF, But Not proBDNF, Reduces Excitability of Fast-Spiking Interneurons in Mouse Dentate Gyrus

(2009) M. M. Holm et al.   JOURNAL OF NEUROSCIENCE

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

Zinc-Mediated Transactivation of TrkB Potentiates the Hippocampal Mossy Fiber-CA3 Pyramid Synapse

(2009) Yang Z. Huang et al.   NEURON

The role of the CA3 hippocampal subregion in spatial memory: A process oriented behavioral assessment

(2009) Paul E. Gilbert et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function

(2008) C. R. Bramham et al.   JOURNAL OF NEUROSCIENCE

Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines

(2008) J.-i. Tanaka et al.   SCIENCE