Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?

Which Effects on Neuroanatomy and Path-Integration Survive? Results of a Randomized Controlled Study on Intensive Balance Training

(2020) Milos Dordevic et al.   Brain Sciences

Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage

(2020) Erin I. Walsh et al.   AGEING RESEARCH REVIEWS

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

(2019) Lauretta El Hayek et al.   JOURNAL OF NEUROSCIENCE

Pharmakologische Therapie der Alzheimer-Demenz

(2019) P. Müller et al.   INTERNIST

Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice

(2019) Julia Leschik et al.   MOLECULAR NEUROBIOLOGY

Physical Exercise as Personalized Medicine for Dementia Prevention?

(2019) Patrick Müllers et al.   Frontiers in Physiology

The Impact of Different Types of Exercise Training on Peripheral Blood Brain-Derived Neurotrophic Factor Concentrations in Older Adults: A Meta-Analysis

(2019) Nastasia Marinus et al.   SPORTS MEDICINE

Inter-Individual Differences in Cognitive Response to a Single Bout of Physical Exercise—A Randomized Controlled Cross-Over Study

(2019) Svenja Schwarck et al.   Journal of Clinical Medicine

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Dance training is superior to repetitive physical exercise in inducing brain plasticity in the elderly

(2018) Kathrin Rehfeld et al.   PLoS One

Insulin and Alzheimer's Disease: Untangling the Web

(2018) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Physical activity for brain health in older adults

(2018) Teresa Liu-Ambrose et al.   Applied Physiology Nutrition and Metabolism

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

(2018) Miia Kivipelto et al.   Nature Reviews Neurology

The Impact of High-Intensity Interval Training on Brain Derived Neurotrophic Factor in Brain: A Mini-Review

(2018) Alberto Jiménez-Maldonado et al.   Frontiers in Neuroscience

Brain Gray Matter Volume Is Modulated by Visual Input and Overall Learning Success but Not by Time Spent on Learning a Complex Balancing Task

(2018) Milos Dordevic et al.   Journal of Clinical Medicine

The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor in healthy adults: a meta-analysis

(2017) Adam Dinoff et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Improvements in Orientation and Balancing Abilities in Response to One Month of Intensive Slackline-Training. A Randomized Controlled Feasibility Study

(2017) Milos Dordevic et al.   Frontiers in Human Neuroscience

Dancing or Fitness Sport? The Effects of Two Training Programs on Hippocampal Plasticity and Balance Abilities in Healthy Seniors

(2017) Kathrin Rehfeld et al.   Frontiers in Human Neuroscience

The Effects of Physical Exercise and Cognitive Training on Memory and Neurotrophic Factors

(2017) Jennifer J. Heisz et al.   JOURNAL OF COGNITIVE NEUROSCIENCE

The metabolic trinity, glucose–glycogen–lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression

(2017) Gerald A. Dienel   NEUROSCIENCE LETTERS

Neurobiology of local and intercellular BDNF signaling

(2017) Manju Sasi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Effect of Interval and Continuous Aerobic Training on Basal Serum and Plasma Brain-Derived Neurotrophic Factor Values in Seniors: A Systematic Review of Intervention Studies

(2017) Lievyn Enette et al.   REJUVENATION RESEARCH

Präventionsstrategien gegen Demenz

(2017) Patrick Müller et al.   ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE

Evolution of Neuroplasticity in Response to Physical Activity in Old Age: The Case for Dancing

(2017) Patrick Müller et al.   Frontiers in Aging Neuroscience

Can physical exercise in old age improve memory and hippocampal function?

(2016) Emrah Duzel et al.   BRAIN

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

Mediators of Physical Activity on Neurocognitive Function: A Review at Multiple Levels of Analysis

(2016) Chelsea M. Stillman et al.   Frontiers in Human Neuroscience

Lactate as a Metabolite and a Regulator in the Central Nervous System

(2016) Patrizia Proia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain-derived Neurotrophic Factor in Megakaryocytes

(2016) Pedro Chacón-Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults

(2016) Anne Maass et al.   NEUROIMAGE

A systematic review of MRI studies examining the relationship between physical fitness and activity and the white matter of the ageing brain

(2016) Claire E. Sexton et al.   NEUROIMAGE

Physical activity and the incidence of multiple sclerosis

(2016) Kirsten S. Dorans et al.   NEUROLOGY

Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?

(2016) Sinéad M. Ryan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Arterial stiffness and sedentary lifestyle: Role of oxidative stress

(2016) Gianfranco Lessiani et al.   VASCULAR PHARMACOLOGY

The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis

(2016) Adam Dinoff et al.   PLoS One

Neurodegenerative Erkrankungen und zelluläre Plastizität als sportmedizinische Herausforderung

(2015) G Kempermann   deutsche zeitschrift fur sportmedizin

Einfluss von Sport auf das zentrale Nervensystem – Molekulare und zelluläre Wirkmechanismen

(2015) P Zimmer et al.   deutsche zeitschrift fur sportmedizin

High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise

(2015) Cinthia Maria Saucedo Marquez et al.   JOURNAL OF APPLIED PHYSIOLOGY

The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

(2015) Cecilie Morland et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

(2015) Kristin L. Szuhany et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

(2015) Mohammad Jodeiri Farshbaf et al.   NEUROMOLECULAR MEDICINE

Theta Burst Firing Recruits BDNF Release and Signaling in Postsynaptic CA1 Neurons in Spike-Timing-Dependent LTP

(2015) Elke Edelmann et al.   NEURON

Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins

(2014) Masaki Takimoto et al.   JOURNAL OF APPLIED PHYSIOLOGY

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

(2014) Sam Norton et al.   LANCET NEUROLOGY

Contributions of glycogen to astrocytic energetics during brain activation

(2014) Gerald A. Dienel et al.   METABOLIC BRAIN DISEASE

Comprehensive review on lactate metabolism in human health

(2014) M. Adeva-Andany et al.   MITOCHONDRION

Physical activity, fitness, and gray matter volume

(2014) Kirk I. Erickson et al.   NEUROBIOLOGY OF AGING

Acute exercise improves motor memory: Exploring potential biomarkers

(2014) Kasper Skriver et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

Benefits of Physical Exercise on the Aging Brain: The Role of the Prefrontal Cortex

(2013) Marika Berchicci et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity

(2013) Elke Edelmann et al.   NEUROPHARMACOLOGY

Structural and functional brain changes related to different types of physical activity across the life span

(2013) Claudia Voelcker-Rehage et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway

(2013) Luigi Bozzo et al.   PLoS One

The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review

(2013) T. Huang et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Metabolic signaling by lactate in the brain

(2013) L. Felipe Barros   TRENDS IN NEUROSCIENCES

Emerging role for astroglial networks in information processing: from synapse to behavior

(2013) Ulrike Pannasch et al.   TRENDS IN NEUROSCIENCES

Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia

(2013) Galit Weinstein et al.   JAMA Neurology

Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): A systematic review of experimental studies in the elderly

(2012) Flávia Gomes de Melo Coelho et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

Non-pharmacological cognitive enhancement

(2012) Martin Dresler et al.   NEUROPHARMACOLOGY

Principles of Exercise Physiology: Responses to Acute Exercise and Long-term Adaptations to Training

(2012) Anita M. Rivera-Brown et al.   PM&R

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Insulin resistance and pathological brain ageing

(2011) B. Cholerton et al.   DIABETIC MEDICINE

Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging

(2011) J. Eric Ahlskog et al.   MAYO CLINIC PROCEEDINGS

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum Brain-Derived Neurotrophic Factor Levels Are Specifically Associated with Memory Performance among Alzheimer’s Disease Cases

(2010) Sid E. O’Bryant et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth

(2010) S. Rauskolb et al.   JOURNAL OF NEUROSCIENCE

BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory

(2010) Michael E. Hopkins et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Physical activities and future risk of Parkinson disease

(2010) Q. Xu et al.   NEUROLOGY

Exercise and time-dependent benefits to learning and memory

(2010) N.C. Berchtold et al.   NEUROSCIENCE

Lactate infusion at rest increases BDNF blood concentration in humans

(2010) Thorsten Schiffer et al.   NEUROSCIENCE LETTERS

Decreased Serum Brain-Derived Neurotrophic Factor Levels in Elderly Korean with Dementia

(2010) Jung Goo Lee et al.   Psychiatry Investigation

Neuroplasticity – Exercise-Induced Response of Peripheral Brain-Derived Neurotrophic Factor

(2010) Kristel Knaepen et al.   SPORTS MEDICINE

Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment

(2010) Orestes Vicente Forlenza et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Endurance training enhances BDNF release from the human brain

(2009) Thomas Seifert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Biological Mechanisms of Physical Activity in Preventing Cognitive Decline

(2009) I. Lista et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

(2009) V. B. Matthews et al.   DIABETOLOGIA

Evidence for a release of brain-derived neurotrophic factor from the brain during exercise

(2009) Peter Rasmussen et al.   EXPERIMENTAL PHYSIOLOGY

Blood Lactate is an Important Energy Source for the Human Brain

(2009) Gerrit van Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I

(2009) Yu-Fan Liu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise and Mental Health: Many Reasons to Move

(2009) Andréa Deslandes et al.   NEUROPSYCHOBIOLOGY

Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update

(2009) Volkmar Leßmann et al.   NEUROSCIENCE RESEARCH

BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses

(2009) Kurt Gottmann et al.   EXPERIMENTAL BRAIN RESEARCH

New insights into brain BDNF function in normal aging and Alzheimer disease

(2008) Lucia Tapia-Arancibia et al.   BRAIN RESEARCH REVIEWS

Brain metabolism dictates the polarity of astrocyte control over arterioles

(2008) Grant R. J. Gordon et al.   NATURE

Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence

(2008) M. Hamer et al.   PSYCHOLOGICAL MEDICINE

Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines

(2008) J.-i. Tanaka et al.   SCIENCE