Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy

Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

(2019) Leanne M Holt et al.   eLife

Impairments in cognitive functions and emotional and social behaviors in a rat lithium-pilocarpine model of temporal lobe epilepsy

(2019) Ilya V. Smolensky et al.   BEHAVIOURAL BRAIN RESEARCH

Microstructure and functional connectivity-based evidence for memory-related regional impairments in the brains of pilocarpine-treated rats

(2019) Yin Jiang et al.   BRAIN RESEARCH BULLETIN

Early treatment with C1 esterase inhibitor improves weight but not memory deficits in a rat model of status epilepticus

(2019) Nicole D. Schartz et al.   PHYSIOLOGY & BEHAVIOR

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

(2018) Ana Covelo et al.   eLife

Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy

(2018) Chiara Falcicchia et al.   Molecular Therapy-Methods & Clinical Development

Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses

(2018) Pei-Yi Lin et al.   Cell Reports

Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies

(2017) Gonzalo Tejeda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

(2017) Philip Hasel et al.   Nature Communications

Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processes

(2016) Víctor Danelon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons

(2015) J. Gibon et al.   JOURNAL OF NEUROSCIENCE

A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus

(2015) Bin Gu et al.   NEURON

Role of brain glycogen in the response to hypoxia and in susceptibility to epilepsy

(2015) Juan C. López-Ramos et al.   Frontiers in Cellular Neuroscience

Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus

(2014) Eva M. Jimenez-Mateos et al.   Brain Structure & Function

Antiseizure effects of TrkB kinase inhibition

(2014) Gumei Liu et al.   EPILEPSIA

New In Vitro Phenotypic Assay for Epilepsy: Fluorescent Measurement of Synchronized Neuronal Calcium Oscillations

(2014) Nathalie Pacico et al.   PLoS One

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

(2014) Jianmin Yang et al.   Cell Reports

Beneficial effects of environmental enrichment and food entrainment in the R6/2 mouse model of Huntington's disease

(2014) Elizabeth A. Skillings et al.   Brain and Behavior

Neuroprotection Signaling of Nuclear Akt in Neuronal Cells

(2014) Jee-Yin Ahn   Experimental Neurobiology

TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders

(2013) Vivek Gupta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy

(2013) Gumei Liu et al.   NEURON

Diphenylarsinic Acid Increased the Synthesis and Release of Neuroactive and Vasoactive Peptides in Rat Cerebellar Astrocytes

(2012) Takayuki Negishi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Excitotoxicity Downregulates TrkB.FL Signaling and Upregulates the Neuroprotective Truncated TrkB Receptors in Cultured Hippocampal and Striatal Neurons

(2012) J. R. Gomes et al.   JOURNAL OF NEUROSCIENCE

Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity

(2012) Ó G Vidaurre et al.   Cell Death & Disease

Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

(2011) Jordi Valles-Ortega et al.   EMBO Molecular Medicine

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

(2011) Albert Giralt et al.   HUMAN MOLECULAR GENETICS

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease

(2010) A Giralt et al.   GENE THERAPY

Disruption of TrkB-Mediated Phospholipase C  Signaling Inhibits Limbic Epileptogenesis

(2010) X. P. He et al.   JOURNAL OF NEUROSCIENCE

High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision

(2010) Benjamin F Grewe et al.   NATURE METHODS

The influence of the astrocyte field on neuronal dynamics and synchronization

(2009) Paolo Allegrini et al.   JOURNAL OF BIOLOGICAL PHYSICS

Brain-derived neurotrophic factor facilitates TrkB down-regulation and neuronal injury after status epilepticus in the rat hippocampus

(2009) Nicolás Unsain et al.   JOURNAL OF NEUROCHEMISTRY

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

Endogenous Truncated TrkB.T1 Receptor Regulates Neuronal Complexity and TrkB Kinase Receptor Function In Vivo

(2009) L. Carim-Todd et al.   JOURNAL OF NEUROSCIENCE

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

Communication between neurons and astrocytes: relevance to the modulation of synaptic and network activity

(2008) Tommaso Fellin   JOURNAL OF NEUROCHEMISTRY