Neurobiology of local and intercellular BDNF signaling

GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

(2017) J Deckert et al.   MOLECULAR PSYCHIATRY

Axonal Endoplasmic Reticulum Ca 2+ Content Controls Release Probability in CNS Nerve Terminals

(2017) Jaime de Juan-Sanz et al.   NEURON

Editing DNA Methylation in the Mammalian Genome

(2016) X. Shawn Liu et al.   CELL

Brain-derived Neurotrophic Factor in Megakaryocytes

(2016) Pedro Chacón-Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat

(2016) M D Lange et al.   MOLECULAR PSYCHIATRY

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity

(2016) Nathan G. Hedrick et al.   NATURE

Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention

(2016) Beatrice Vignoli et al.   NEURON

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

(2016) Xiaobei Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamatergic axon-derived BDNF controls GABAergic synaptic differentiation in the cerebellum

(2016) Albert I. Chen et al.   Scientific Reports

The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders

(2016) A Cattaneo et al.   Translational Psychiatry

proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons

(2015) J. Gibon et al.   JOURNAL OF NEUROSCIENCE

Autocrine Action of BDNF on Dendrite Development of Adult-Born Hippocampal Neurons

(2015) L. Wang et al.   JOURNAL OF NEUROSCIENCE

Impermanence of dendritic spines in live adult CA1 hippocampus

(2015) Alessio Attardo et al.   NATURE

Labelling and optical erasure of synaptic memory traces in the motor cortex

(2015) Akiko Hayashi-Takagi et al.   NATURE

Neuronal circuits for fear and anxiety

(2015) Philip Tovote et al.   NATURE REVIEWS NEUROSCIENCE

The BDNF Val66Met variant affects gene expression through miR-146b

(2015) Pei-Ken Hsu et al.   NEUROBIOLOGY OF DISEASE

Spontaneous Activity Drives Local Synaptic Plasticity In Vivo

(2015) Johan Winnubst et al.   NEURON

Theta Burst Firing Recruits BDNF Release and Signaling in Postsynaptic CA1 Neurons in Spike-Timing-Dependent LTP

(2015) Elke Edelmann et al.   NEURON

A computational theory of hippocampal function, and tests of the theory: New developments

(2015) Raymond P. Kesner et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin

(2015) Yu-Hui Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo

(2014) Jeffrey Helgager et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Positive Autoregulatory BDNF Feedback Loop via C/EBP  Mediates Hippocampal Memory Consolidation

(2014) D. Bambah-Mukku et al.   JOURNAL OF NEUROSCIENCE

Engineering a memory with LTD and LTP

(2014) Sadegh Nabavi et al.   NATURE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease

(2014) Joshua L. Plotkin et al.   NEURON

Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP

(2014) Hyungju Park et al.   NEURON

High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons

(2014) Thomas Andreska et al.   Frontiers in Cellular Neuroscience

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

(2014) Jianmin Yang et al.   Cell Reports

Two-Stage Translational Control of Dentate Gyrus LTP Consolidation Is Mediated by Sustained BDNF-TrkB Signaling to MNK

(2014) Debabrata Panja et al.   Cell Reports

Polarized Expression of p75NTR Specifies Axons during Development and Adult Neurogenesis

(2014) Emanuela Zuccaro et al.   Cell Reports

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

TrkB Signaling Directs the Incorporation of Newly Generated Periglomerular Cells in the Adult Olfactory Bulb

(2013) M. Bergami et al.   JOURNAL OF NEUROSCIENCE

EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons

(2013) Dirk Puehringer et al.   NATURE NEUROSCIENCE

The contextual brain: implications for fear conditioning, extinction and psychopathology

(2013) Stephen Maren et al.   NATURE REVIEWS NEUROSCIENCE

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

Acute and chronic interference with BDNF/TrkB-signaling impair LTP selectively at mossy fiber synapses in the CA3 region of mouse hippocampus

(2013) Sandra Schildt et al.   NEUROPHARMACOLOGY

Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity

(2013) Elke Edelmann et al.   NEUROPHARMACOLOGY

BDNF mechanisms in late LTP formation: A synthesis and breakdown

(2013) Debabrata Panja et al.   NEUROPHARMACOLOGY

The BDNF Val66Met Polymorphism Modulates the Generalization of Cued Fear Responses to a Novel Context

(2013) Andreas Mühlberger et al.   NEUROPSYCHOPHARMACOLOGY

Deep Sequencing and High-Resolution Imaging Reveal Compartment-Specific Localization of Bdnf mRNA in Hippocampal Neurons

(2013) T. J. Will et al.   Science Signaling

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

(2013) Agustin Anastasia et al.   Nature Communications

NMDA-Dependent Switch of proBDNF Actions on Developing GABAergic Synapses

(2012) A. Langlois et al.   CEREBRAL CORTEX

Genetics of Anxiety Disorders - Status Quo and Quo Vadis

(2012) Katharina Domschke et al.   CURRENT PHARMACEUTICAL DESIGN

BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons

(2012) Sandra Dieni et al.   JOURNAL OF CELL BIOLOGY

TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

(2012) Kwok-On Lai et al.   NATURE NEUROSCIENCE

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice

(2012) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses

(2012) H. S. Je et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The size and burden of mental disorders and other disorders of the brain in Europe 2010

(2011) H.U. Wittchen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

TrkB as a Potential Synaptic and Behavioral Tag

(2011) Y. Lu et al.   JOURNAL OF NEUROSCIENCE

Postsynaptic BDNF signalling regulates long-term potentiation at thalamo-amygdala afferents

(2011) S. Meis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Learning-related feedforward inhibitory connectivity growth required for memory precision

(2011) Sarah Ruediger et al.   NATURE

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse

(2011) Enhui Pan et al.   NEURON

Seeking a Spotless Mind: Extinction, Deconsolidation, and Erasure of Fear Memory

(2011) Stephen Maren   NEURON

Self-amplifying autocrine actions of BDNF in axon development

(2011) P.-L. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review on experimental and clinical genetic associations studies on fear conditioning, extinction and cognitive-behavioral treatment

(2011) T B Lonsdorf et al.   Translational Psychiatry

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Neurotrophin receptors TrkB.T1 and p75NTR cooperate in modulating both functional and structural plasticity in mature hippocampal neurons

(2010) K. Michaelsen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Activity-Dependent Release of Endogenous BDNF From Mossy Fibers Evokes a TRPC3 Current and Ca2+ Elevations in CA3 Pyramidal Neurons

(2010) Yong Li et al.   JOURNAL OF NEUROPHYSIOLOGY

Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth

(2010) S. Rauskolb et al.   JOURNAL OF NEUROSCIENCE

BNDF modulates normal human hippocampal ageing

(2010) F Sambataro et al.   MOLECULAR PSYCHIATRY

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

(2010) Vassiliki Nikoletopoulou et al.   NATURE

Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons

(2010) Yuanyuan Ji et al.   NATURE NEUROSCIENCE

Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear

(2010) Hans-Christian Pape et al.   PHYSIOLOGICAL REVIEWS

A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human

(2010) F. Soliman et al.   SCIENCE

Experience-dependent regulation of TrkB isoforms in rodent visual cortex

(2009) Bethany K. Bracken et al.   Developmental Neurobiology

TrkB Modulates Fear Learning and Amygdalar Synaptic Plasticity by Specific Docking Sites

(2009) G. Musumeci et al.   JOURNAL OF NEUROSCIENCE

Endogenous Truncated TrkB.T1 Receptor Regulates Neuronal Complexity and TrkB Kinase Receptor Function In Vivo

(2009) L. Carim-Todd et al.   JOURNAL OF NEUROSCIENCE

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Rapid formation and selective stabilization of synapses for enduring motor memories

(2009) Tonghui Xu et al.   NATURE

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

Ama“Zinc” Link between TrkB Transactivation and Synaptic Plasticity

(2009) Guhan Nagappan et al.   NEURON

Zinc-Mediated Transactivation of TrkB Potentiates the Hippocampal Mossy Fiber-CA3 Pyramid Synapse

(2009) Yang Z. Huang et al.   NEURON

Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety

(2009) Michael Davis et al.   NEUROPSYCHOPHARMACOLOGY

Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update

(2009) Volkmar Leßmann et al.   NEUROSCIENCE RESEARCH

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

(2009) G. Nagappan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation

(2009) C. Chiaruttini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

Dopamine D1 Receptor-induced Signaling through TrkB Receptors in Striatal Neurons

(2008) Yuriko Iwakura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes

(2008) Matteo Bergami et al.   JOURNAL OF CELL BIOLOGY

Backpropagating Action Potentials Trigger Dendritic Release of BDNF during Spontaneous Network Activity

(2008) N. Kuczewski et al.   JOURNAL OF NEUROSCIENCE

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

(2008) M. Bergami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines

(2008) J.-i. Tanaka et al.   SCIENCE

Brain-Derived Neurotrophic Factor Levels in the Nervous System of Wild-Type and Neurotrophin Gene Mutant Mice

(2003) Roland Kolbeck et al.   JOURNAL OF NEUROCHEMISTRY