Lactate reduces epileptiform activity through HCA1 and GIRK channel activation in rat subicular neurons in an in vitro model

Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production

(2019) Jean Pierre Oses et al.   EPILEPSY RESEARCH

Modulation of hippocampal excitability via the hydroxycarboxylic acid receptor 1

(2018) Gabriel Herrera-López et al.   HIPPOCAMPUS

Effects of Systemic Metabolic Fuels on Glucose and Lactate Levels in the Brain Extracellular Compartment of the Mouse

(2017) Alexandria Béland-Millar et al.   Frontiers in Neuroscience

A Probable Dual Mode of Action for Both L- and D-Lactate Neuroprotection in Cerebral Ischemia

(2015) Ximena Castillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Is L-Lactate a Novel Signaling Molecule in the Brain?

(2015) Valentina Mosienko et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lactate: Brain Fuel in Human Traumatic Brain Injury: A Comparison with Normal Healthy Control Subjects

(2015) Thomas C. Glenn et al.   JOURNAL OF NEUROTRAUMA

Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain

(2015) Swagata Ghatak et al.   JOURNAL OF PHYSIOLOGY-LONDON

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

(2015) Masoud Ghamari-Langroudi et al.   NATURE

Targeting LDH enzymes with a stiripentol analog to treat epilepsy

(2015) N. Sada et al.   SCIENCE

Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

(2014) Zhe Shen et al.   CNS Neuroscience & Therapeutics

ILAE Official Report: A practical clinical definition of epilepsy

(2014) Robert S. Fisher et al.   EPILEPSIA

Depression biased non-Hebbian spike-timing-dependent synaptic plasticity in the rat subiculum

(2014) Anurag Pandey et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate-mediated glia-neuronal signalling in the mammalian brain

(2014) F. Tang et al.   Nature Communications

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

Transition in subicular burst firing neurons from epileptiform activity to suppressed state by feedforward inhibition

(2013) Nirnath Sah et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Experimental Models of Status Epilepticus and Neuronal Injury for Evaluation of Therapeutic Interventions

(2013) Doodipala Reddy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early Activation of Ventral Hippocampus and Subiculum during Spontaneous Seizures in a Rat Model of Temporal Lobe Epilepsy

(2013) I. Toyoda et al.   JOURNAL OF NEUROSCIENCE

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

MCT2 Expression and Lactate Influx in Anorexigenic and Orexigenic Neurons of the Arcuate Nucleus

(2013) Christian Cortes-Campos et al.   PLoS One

Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway

(2013) Luigi Bozzo et al.   PLoS One

l-pGlu-(2-propyl)-l-His-l-ProNH2 attenuates 4-aminopyridine-induced epileptiform activity and sodium current: a possible action of new thyrotropin-releasing hormone analog for its anticonvulsant potential

(2011) N. Sah et al.   NEUROSCIENCE

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

Direct Measurement of Extracellular Lactate in the Human Hippocampus During Spontaneous Seizures

(2010) Matthew J. During et al.   JOURNAL OF NEUROCHEMISTRY

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy

(2008) A. Knopp et al.   BRAIN

Epileptiform activity induces distance-dependent alterations of the Ca2+extrusion mechanism in the apical dendrites of subicular pyramidal neurons

(2008) Kalyan V. Srinivas et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte-Neuron Lactate-Shuttle Hypothesis

(2008) J. S. Erlichman et al.   JOURNAL OF NEUROSCIENCE

Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus

(2007) Karel Slais et al.   EXPERIMENTAL NEUROLOGY