Functions of cilia in cardiac development and disease

Immotile cilia mechanically sense the direction of fluid flow for left-right determination

(2023) Takanobu A. Katoh et al.   SCIENCE

Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry

(2023) Lydia Djenoune et al.   SCIENCE

Multiple pkd and piezo gene family members are required for atrioventricular valve formation

(2023) Thomas Juan et al.   Nature Communications

ATP‐induced conformational change of axonemal outer dynein arms revealed by cryo‐electron tomography

(2023) Noemi Zimmermann et al.   EMBO JOURNAL

Primary cilia as dynamic and diverse signalling hubs in development and disease

(2023) Pleasantine Mill et al.   NATURE REVIEWS GENETICS

IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans

(2023) Zeineb Bakey et al.   PLoS Genetics

Editorial: Signaling by primary cilia in development and disease

(2023) Sung-Eun Kim et al.   Frontiers in Cell and Developmental Biology

Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain

(2023) Kathryn M. Brewer et al.   eNeuro

Primary Cilia and Their Role in Acquired Heart Disease

(2022) Zachariah E. Hale et al.   Cells

Endocardial-Myocardial Interactions During Early Cardiac Differentiation and Trabeculation

(2022) Xianghu Qu et al.   Frontiers in Cardiovascular Medicine

Situs Inversus Totalis: A Clinical Review

(2022) Katalin Eitler et al.   International Journal of General Medicine

A multi-disciplinary, comprehensive approach to management of children with heterotaxy

(2022) Thomas G. Saba et al.   Orphanet Journal of Rare Diseases

Genetic insights into non-syndromic Tetralogy of Fallot

(2022) Nouf J. Althali et al.   Frontiers in Physiology

Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development

(2022) Cayla E Jewett et al.   eLife

ALMS1 Regulates TGF-β Signaling and Morphology of Primary Cilia

(2021) María Álvarez-Satta et al.   Frontiers in Cell and Developmental Biology

Phosphorylation and Ubiquitylation Regulate Protein Trafficking, Signaling, and the Biogenesis of Primary Cilia

(2021) Elena A. May et al.   Frontiers in Cell and Developmental Biology

Epigenetic Regulation of Cardiac Neural Crest Cells

(2021) Shun Yan et al.   Frontiers in Cell and Developmental Biology

Heart Development and Congenital Structural Heart Defects

(2021) Lucile Houyel et al.   Annual Review of Genomics and Human Genetics

Creld1 regulates myocardial development and function

(2021) Vera Beckert et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genomic frontiers in congenital heart disease

(2021) Sarah U. Morton et al.   Nature Reviews Cardiology

Clinical characteristics and genetic spectrum of 26 individuals of Chinese origin with primary ciliary dyskinesia

(2021) Xinyue Zhao et al.   Orphanet Journal of Rare Diseases

DNAH11 compound heterozygous variants cause heterotaxy and congenital heart disease

(2021) Hong Xia et al.   PLoS One

Oviductal motile cilia are essential for oocyte pickup but dispensable for sperm and embryo transport

(2021) Shuiqiao Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitral valve prolapse with ventricular arrhythmias: does it carries a worse prognosis?

(2021) Gloria Vassilikì Coutsoumbas et al.   EUROPEAN HEART JOURNAL SUPPLEMENTS

An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field

(2021) Suly Saray Villa Vasquez et al.   MOLECULAR BIOLOGY OF THE CELL

A change of heart: new roles for cilia in cardiac development and disease

(2021) Lydia Djenoune et al.   Nature Reviews Cardiology

Cilia locally synthesize proteins to sustain their ultrastructure and functions

(2021) Kai Hao et al.   Nature Communications

Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis

(2021) Jordan E. Morningstar et al.   Journal of the American Heart Association

Development of the human heart

(2020) Marieke F.J. Buijtendijk et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Desert Hedgehog-Primary Cilia Cross Talk Shapes Mitral Valve Tissue by Organizing Smooth Muscle Actin

(2020) Diana Fulmer et al.   DEVELOPMENTAL BIOLOGY

Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

(2020) Mi-Lang Kyun et al.   Cell Reports

Transport of Ciliary Membrane Proteins

(2020) Huan Long et al.   Frontiers in Cell and Developmental Biology

Role of cilia in the pathogenesis of congenital heart disease

(2020) George C. Gabriel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart

(2020) Xueyu Li et al.   Protein & Cell

Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure

(2020) Charles E MacKay et al.   eLife

Mechanisms of heart valve development and disease

(2020) Anna O'Donnell et al.   DEVELOPMENT

Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis

(2020) Marina Peralta et al.   Cell Reports

The heart of the neural crest: cardiac neural crest cells in development and regeneration

(2020) Rajani M. George et al.   DEVELOPMENT

The molecular structure of mammalian primary cilia revealed by cryo-electron tomography

(2020) Petra Kiesel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Survival in Children With Congenital Heart Disease: Have We Reached a Peak at 97%?

(2020) Zacharias Mandalenakis et al.   Journal of the American Heart Association

Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development

(2019) Emilie W. Olstad et al.   CURRENT BIOLOGY

The non‐genetic paternal factors for congenital heart defects: A systematic review and meta‐analysis

(2019) Jiayu Peng et al.   CLINICAL CARDIOLOGY

Three-dimensional architecture of epithelial primary cilia

(2019) Shufeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary cilia defects causing mitral valve prolapse

(2019) Katelynn A. Toomer et al.   Science Translational Medicine

Meta‐analysis of genotype‐phenotype associations in Bardet‐Biedl syndrome uncovers differences among causative genes

(2019) Veronika Niederlova et al.   HUMAN MUTATION

The cilium as a force sensor−myth versus reality

(2019) Rita R. Ferreira et al.   JOURNAL OF CELL SCIENCE

Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis

(2019) Martin D. Burkhalter et al.   JOURNAL OF CLINICAL INVESTIGATION

DNAH11 variants and its association with congenital heart disease and heterotaxy syndrome

(2019) Sida Liu et al.   Scientific Reports

Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis

(2019) Diana Fulmer et al.   CIRCULATION

The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life

(2019) Cheryl Mei Jun Tan et al.   FETAL DIAGNOSIS AND THERAPY

The Chiral Looping of the Embryonic Heart Is Formed by the Combination of Three Axial Asymmetries

(2019) Hisao Honda et al.   BIOPHYSICAL JOURNAL

Loss of ciliary transition zone protein TMEM107 leads to heterotaxy in mice

(2019) Natalia A. Shylo et al.   DEVELOPMENTAL BIOLOGY

Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila

(2019) Jean-André Lapart et al.   eLife

Mechanotransduction in the Cardiovascular System: From Developmental Origins to Homeostasis and Pathology

(2019) Gloria Garoffolo et al.   Cells

Intraflagellar transporter protein 140 (IFT140), a component of IFT-A complex, is essential for male fertility and spermiogenesis in mice

(2018) Yong Zhang et al.   Cytoskeleton

CRELD1 gene variants and atrioventricular septal defects in Down syndrome

(2018) Ambreen Asim et al.   GENE

Mechanisms of Trabecular Formation and Specification During Cardiogenesis

(2018) Mingfu Wu   PEDIATRIC CARDIOLOGY

Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects

(2018) Chunjie Liu et al.   Genome Medicine

Cilium structure, assembly, and disassembly regulated by the cytoskeleton

(2018) Mary Mirvis et al.   BIOCHEMICAL JOURNAL

Trisomy 21 Represses Cilia Formation and Function

(2018) Domenico F. Galati et al.   DEVELOPMENTAL CELL

Risk factors for situs defects and congenital heart disease in primary ciliary dyskinesia

(2018) Sunayna Best et al.   THORAX

Homozygous loss-of-function mutations in MNS1 cause laterality defects and likely male infertility

(2018) Asaf Ta-Shma et al.   PLoS Genetics

A Novel Mouse Model for Cilia-Associated Cardiovascular Anomalies with a High Penetrance of Total Anomalous Pulmonary Venous Return

(2018) Tara A. Burns et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association

(2018) Mary Ella Pierpont et al.   CIRCULATION

Thoraco-Abdominal Abnormalities in Bardet-Biedl Syndrome: Situs Inversus and Heterotaxy

(2018) Andrew J. Olson et al.   JOURNAL OF PEDIATRICS

Primary Cilia as Signaling Hubs in Health and Disease

(2018) Yuhei Nishimura et al.   Advanced Science

DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport

(2017) Verity L Hartill et al.   HUMAN MOLECULAR GENETICS

Primary Cilium-Dependent Signaling Mechanisms

(2017) Rajasekharreddy Pala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases

(2017) Fabian Marc Schmid et al.   JOURNAL OF CELL BIOLOGY

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism for generation of left isomerism in Ccdc40 mutant embryos

(2017) Kelsey F. Sugrue et al.   PLoS One

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis

(2017) Salih Gencer et al.   Science Signaling

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

G-Protein-Coupled Receptor Signaling in Cilia

(2017) Kirk Mykytyn et al.   Cold Spring Harbor Perspectives in Biology

Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development

(2017) Liam A. Ridge et al.   PLoS Genetics

Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

(2017) Kenzo Ivanovitch et al.   eLife

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis

(2017) Salih Gencer et al.   Science Signaling

TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization

(2016) Julia Wallmeier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes

(2016) Gerard W. Dougherty et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Congenital Heart Disease and Primary Ciliary Dyskinesia

(2016) Mike John Harrison et al.   Paediatric Respiratory Reviews

Axoneme Structure from Motile Cilia

(2016) Takashi Ishikawa   Cold Spring Harbor Perspectives in Biology

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

The Intraflagellar Transport Machinery

(2016) Michael Taschner et al.   Cold Spring Harbor Perspectives in Biology

Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling

(2016) Søren T. Christensen et al.   Cold Spring Harbor Perspectives in Biology

DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia

(2016) You Li et al.   PLoS Genetics

Left-right asymmetry in the light of TOR: An update on what we know so far

(2015) Teresa Casar Tena et al.   BIOLOGY OF THE CELL

Intraciliary Calcium Oscillations Initiate Vertebrate Left-Right Asymmetry

(2015) Shiaulou Yuan et al.   CURRENT BIOLOGY

Cilia: Organelles at the Heart of Heart Disease

(2015) Vijay Narasimhan et al.   CURRENT BIOLOGY

Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish

(2015) L. A. Samsa et al.   DEVELOPMENT

IFT46 plays an essential role in cilia development

(2015) Mi-Sun Lee et al.   DEVELOPMENTAL BIOLOGY

Absence of Radial Spokes in Mouse Node Cilia Is Required for Rotational Movement but Confers Ultrastructural Instability as a Trade-Off

(2015) Kyosuke Shinohara et al.   DEVELOPMENTAL CELL

Mutations in DCHS1 cause mitral valve prolapse

(2015) Ronen Durst et al.   NATURE

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

(2015) You Li et al.   NATURE

IFT–Cargo Interactions and Protein Transport in Cilia

(2015) Karl F. Lechtreck   TRENDS IN BIOCHEMICAL SCIENCES

GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis

(2015) Boyan Zhang et al.   PLOS BIOLOGY

CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation

(2014) Rim Hjeij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Role of cilia in structural birth defects: Insights from ciliopathy mutant mouse models

(2014) Rama Rao Damerla et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Laterality Defects Other Than Situs Inversus Totalis in Primary Ciliary Dyskinesia

(2014) Adam J Shapiro et al.   CHEST

Left-Right Organizer Flow Dynamics: How Much Cilia Activity Reliably Yields Laterality?

(2014) Pedro Sampaio et al.   DEVELOPMENTAL CELL

Meckel–Gruber Syndrome: a population-based study on prevalence, prenatal diagnosis, clinical features, and survival in Europe

(2014) Ingeborg Barisic et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The functional diversity of essential genes required for mammalian cardiac development

(2014) Christopher Clowes et al.   GENESIS

How do cilia organize signalling cascades?

(2014) M. V. Nachury   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Talpid3-Binding Centrosomal Protein Cep120 Is Required for Centriole Duplication and Proliferation of Cerebellar Granule Neuron Progenitors

(2014) Chuanqing Wu et al.   PLoS One

Orphan G-Protein Coupled Receptor 22 (Gpr22) Regulates Cilia Length and Structure in the Zebrafish Kupffer’s Vesicle

(2014) Daphne Verleyen et al.   PLoS One

The primary cilium

(2014) Andrew M Fry et al.   Organogenesis

Genetics of Valvular Heart Disease

(2014) Stephanie LaHaye et al.   Current Cardiology Reports

Mutations in SPAG1 Cause Primary Ciliary Dyskinesia Associated with Defective Outer and Inner Dynein Arms

(2013) Michael R. Knowles et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ARMC4 Mutations Cause Primary Ciliary Dyskinesia with Randomization of Left/Right Body Asymmetry

(2013) Rim Hjeij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation

(2013) Leigh Ann Samsa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Primary Ciliary Dyskinesia. Recent Advances in Diagnostics, Genetics, and Characterization of Clinical Disease

(2013) Michael R. Knowles et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Congenital heart disease: emerging themes linking genetics and development

(2013) Shiaulou Yuan et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo

(2013) J. P. Mahaffey et al.   DEVELOPMENT

Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left–right axis formation

(2013) Daisuke Takao et al.   DEVELOPMENTAL BIOLOGY

Centrosomal Protein DZIP1 Regulates Hedgehog Signaling by Promoting Cytoplasmic Retention of Transcription Factor GLI3 and Affecting Ciliogenesis

(2013) Chengbing Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined exome and whole-genome sequencing identifies mutations inARMC4as a cause of primary ciliary dyskinesia with defects in the outer dynein arm

(2013) Alexandros Onoufriadis et al.   JOURNAL OF MEDICAL GENETICS

DYX1C1 is required for axonemal dynein assembly and ciliary motility

(2013) Aarti Tarkar et al.   NATURE GENETICS

Nongenetic Risk Factors and Congenital Heart Defects

(2013) Sonali S. Patel et al.   PEDIATRIC CARDIOLOGY

LRRC6 Mutation Causes Primary Ciliary Dyskinesia with Dynein Arm Defects

(2013) Amjad Horani et al.   PLoS One

The Dynamic Right-to-Left Translocation of Cerl2 Is Involved in the Regulation and Termination of Nodal Activity in the Mouse Node

(2013) José Manuel Inácio et al.   PLoS One

The Ciliary Protein Ftm Is Required for Ventricular Wall and Septal Development

(2013) Christoph Gerhardt et al.   PLoS One

Roles of cilia, fluid flow, and Ca2+ signaling in breaking of left–right symmetry

(2013) Satoko Yoshiba et al.   TRENDS IN GENETICS

Signaling and Transcriptional Networks in Heart Development and Regeneration

(2013) B. G. Bruneau   Cold Spring Harbor Perspectives in Biology

Cilia and coordination of signaling networks during heart development

(2013) Karen Koefoed et al.   Organogenesis

Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking

(2013) Martin D. Burkhalter et al.   Cell Reports

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

(2013) Christian Alexandro Clement et al.   Cell Reports

Cauli: A Mouse Strain with an Ift140 Mutation That Results in a Skeletal Ciliopathy Modelling Jeune Syndrome

(2013) Kerry A. Miller et al.   PLoS Genetics

Whole-Exome Capture and Sequencing Identifies HEATR2 Mutation as a Cause of Primary Ciliary Dyskinesia

(2012) Amjad Horani et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Congenital heart disease and the specification of left-right asymmetry

(2012) Richard J. B. Francis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High Prevalence of Respiratory Ciliary Dysfunction in Congenital Heart Disease Patients With Heterotaxy

(2012) Nader Nakhleh et al.   CIRCULATION

Cilia, KIF3 molecular motor and nodal flow

(2012) Nobutaka Hirokawa et al.   CURRENT OPINION IN CELL BIOLOGY

Cilia functions in development

(2012) Iain A Drummond   CURRENT OPINION IN CELL BIOLOGY

Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1

(2012) L. Alten et al.   DEVELOPMENT

Defective Nodal and Cerl2 expression in the Arl13bhnn mutant node underlie its heterotaxia

(2012) Christine E. Larkins et al.   DEVELOPMENTAL BIOLOGY

Severe aortic stenosis, bicuspid aortic valve and atrial septal defect in a child with Joubert Syndrome and Related Disorders (JSRD) – A case report and review of congenital heart defects reported in the human ciliopathies

(2012) Natalya Karp et al.   European Journal of Medical Genetics

Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia

(2012) Hannah M Mitchison et al.   NATURE GENETICS

Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation

(2012) S. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2

(2012) S. Yoshiba et al.   SCIENCE

Two rotating cilia in the node cavity are sufficient to break left–right symmetry in the mouse embryo

(2012) Kyosuke Shinohara et al.   Nature Communications

Fluid flow and interlinked feedback loops establish left–right asymmetric decay of Cerl2 mRNA

(2012) Tetsuya Nakamura et al.   Nature Communications

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

(2011) Liyun Sang et al.   CELL

Primary cilia and organogenesis: is Hedgehog the only sculptor?

(2011) Evangelia Tasouri et al.   CELL AND TISSUE RESEARCH

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2

(2011) S. Field et al.   DEVELOPMENT

Pkd1l1 complexes with Pkd2 on motile cilia and functions to establish the left-right axis

(2011) K. Kamura et al.   DEVELOPMENT

Left–right asymmetry in the level of active Nodal protein produced in the node is translated into left–right asymmetry in the lateral plate of mouse embryos

(2011) Aiko Kawasumi et al.   DEVELOPMENTAL BIOLOGY

The gastrocoel roof plate in embryos of different frogs

(2011) Natalia Sáenz-Ponce et al.   DIFFERENTIATION

Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia

(2011) J. B. Wallingford et al.   GENES & DEVELOPMENT

Birth Prevalence of Congenital Heart Disease Worldwide

(2011) Denise van der Linde et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning

(2011) K. A. Fakhro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow

(2010) Jonathan Stevens et al.   BMC DEVELOPMENTAL BIOLOGY

Neuregulin 1 Sustains the Gene Regulatory Network in Both Trabecular and Nontrabecular Myocardium

(2010) Donna Lai et al.   CIRCULATION RESEARCH

The Nodal Inhibitor Coco Is a Critical Target of Leftward Flow in Xenopus

(2010) Axel Schweickert et al.   CURRENT BIOLOGY

Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome

(2010) C. Cui et al.   Disease Models & Mechanisms

Origin of cardiac progenitor cells in the developing and postnatal heart

(2010) Elizabeth N. Kuhn et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning

(2010) Hai Song et al.   NATURE

Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia

(2010) Antonia Borovina et al.   NATURE CELL BIOLOGY

The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation

(2010) Anita Becker-Heck et al.   NATURE GENETICS

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Cardiac progenitor migration and specification

(2010) Andrea Münsterberg et al.   Cell Adhesion & Migration

Making sense of cilia in disease: The human ciliopathies

(2009) Kate Baker et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

An Hh-Dependent Pathway in Lateral Plate Mesoderm Enables the Generation of Left/Right Asymmetry

(2009) Charisios D. Tsiairis et al.   CURRENT BIOLOGY

Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos

(2009) S. Oki et al.   DEVELOPMENT

sonic hedgehog is required in pulmonary endoderm for atrial septation

(2009) A. D. Hoffmann et al.   DEVELOPMENT

Electron-tomographic analysis of intraflagellar transport particle trains in situ

(2009) Gaia Pigino et al.   JOURNAL OF CELL BIOLOGY

The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation

(2009) C. A. Clement et al.   JOURNAL OF CELL SCIENCE

Various facets of vertebrate cilia: motility, signaling, and role in adult neurogenesis

(2009) Shihhui HUANG et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy

(2009) Z. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

Histology Atlas of the Developing Mouse Heart with Emphasis on E11.5 to E18.5

(2009) Saija M. Savolainen et al.   TOXICOLOGIC PATHOLOGY

Left-Right Determination: Involvement of Molecular Motor KIF3, Cilia, and Nodal Flow

(2009) N. Hirokawa et al.   Cold Spring Harbor Perspectives in Biology

Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart

(2008) M. M. Goddeeris et al.   DEVELOPMENT

Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain

(2008) Marat Gorivodsky et al.   DEVELOPMENTAL BIOLOGY

Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis

(2008) Jennifer Slough et al.   DEVELOPMENTAL DYNAMICS

Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells

(2008) Tae Joo Park et al.   NATURE GENETICS