G-Protein-Coupled Receptor Signaling in Cilia

β-Adrenergic Control of Hippocampal Function: Subserving the Choreography of Synaptic Information Storage and Memory

(2016) Hardy Hagena et al.   CEREBRAL CORTEX

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

(2016) Keren I Hilgendorf et al.   CURRENT OPINION IN CELL BIOLOGY

Cystic Kidney Disease: A Primer

(2015) Monica T. Cramer et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

TGR5 in the Cholangiociliopathies

(2015) Tatyana V. Masyuk et al.   DIGESTIVE DISEASES

The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels

(2015) Jaskirat Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of β-arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization

(2015) Jill A. Green et al.   MOLECULAR AND CELLULAR BIOLOGY

The pharmacology of bitter taste receptors and their role in human airways

(2015) Philippe Devillier et al.   PHARMACOLOGY & THERAPEUTICS

Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment

(2015) Yue Jiang et al.   Nature Communications

Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control

(2015) Yoshihiro Omori et al.   PLoS One

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

(2014) Daqing Jin et al.   NATURE CELL BIOLOGY

Hippocampal and Cortical Primary Cilia Are Required for Aversive Memory in Mice

(2014) Nicolas F. Berbari et al.   PLoS One

Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons

(2014) A. I. Koemeter-Cox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

(2013) Anatoliy I. Masyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli

(2013) Xingjian Jin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Intrarenal Renin-Angiotensin and Dopaminergic Systems

(2013) Robert M. Carey   HYPERTENSION

Heterotrimeric G Protein Subunit G 13 Is Critical to Olfaction

(2013) F. Li et al.   JOURNAL OF NEUROSCIENCE

Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease

(2013) V. E. Torres et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

GPR88 Reveals a Discrete Function of Primary Cilia as Selective Insulators of GPCR Cross-Talk

(2013) Aaron Marley et al.   PLoS One

Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

(2013) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia

(2013) Alexander V. Loktev et al.   Cell Reports

A Chemical Screen Identifies Class A G-Protein Coupled Receptors As Regulators of Cilia

(2012) Prachee Avasthi et al.   ACS Chemical Biology

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

(2012) Xiao-long Tang et al.   ACTA PHARMACOLOGICA SINICA

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

(2012) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Heteromerization of Ciliary G Protein-Coupled Receptors in the Mouse Brain

(2012) Jill A. Green et al.   PLoS One

Perspective: TGR5 (Gpbar-1) in liver physiology and disease

(2012) Verena Keitel et al.   Clinics and Research in Hepatology and Gastroenterology

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

(2011) M. Tuson et al.   DEVELOPMENT

TGR5 in the Biliary Tree

(2011) Verena Keitel et al.   DIGESTIVE DISEASES

Dopamine Receptor Type 5 in the Primary Cilia Has Dual Chemo- and Mechano-Sensory Roles

(2011) Shakila Abdul-Majeed et al.   HYPERTENSION

Photoreceptor Signaling: Supporting Vision across a Wide Range of Light Intensities

(2011) Vadim Y. Arshavsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Type 3 Adenylyl Cyclase Is Required for Novel Object Learning and Extinction of Contextual Memory: Role of cAMP Signaling in Primary Cilia

(2011) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

(2010) Verena Keitel et al.   BIOLOGICAL CHEMISTRY

Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins

(2010) Jacqueline S. Domire et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Beta-arrestins as regulators of signal termination and transduction: How do they determine what to scaffold?

(2010) Kathryn A. DeFea   CELLULAR SIGNALLING

Somatostatin Signaling in Neuronal Cilia Is Criticalfor Object Recognition Memory

(2010) E. B. Einstein et al.   JOURNAL OF NEUROSCIENCE

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Olfactory Cilia: Linking Sensory Cilia Function and Human Disease

(2009) P. M. Jenkins et al.   CHEMICAL SENSES

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

(2009) Verena Keitel et al.   HEPATOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese

(2009) Zhenshan Wang et al.   PLoS One

ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification

(2009) Aaron B. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors

(2008) Anatoliy I. Masyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cholangiocyte primary cilia in liver health and disease

(2008) Anatoliy I. Masyuk et al.   DEVELOPMENTAL DYNAMICS

Ric-8B interacts with Gαolf and Gγ13 and co-localizes with Gαolf, Gβ1 and Gγ13 in the cilia of olfactory sensory neurons

(2008) Daniel S. Kerr et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-coupled Receptors

(2008) Nicolas F. Berbari et al.   MOLECULAR BIOLOGY OF THE CELL

G Protein–Coupled Receptor Sorting to Endosomes and Lysosomes

(2007) Adriano Marchese et al.   Annual Review of Pharmacology and Toxicology

Agonist-selective mechanisms of GPCR desensitization

(2007) E Kelly et al.   BRITISH JOURNAL OF PHARMACOLOGY

Somatostatinergic systems in brain: Networks and functions

(2007) Cécile Viollet et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY