Left-right asymmetry in the light of TOR: An update on what we know so far

Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity

(2015) Nicole L. Umberger et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle

(2014) Peixiang Zhang et al.   Cell Metabolism

The myosin ID pathway and left-right asymmetry in Drosophila

(2014) Charles Géminard et al.   GENESIS

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGFβ signaling in establishing left–right asymmetry

(2014) Hidetaka Shiratori et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish

(2013) A. Navis et al.   DEVELOPMENT

Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left–right axis formation

(2013) Daisuke Takao et al.   DEVELOPMENTAL BIOLOGY

A unified model for left–right asymmetry? Comparison and synthesis of molecular models of embryonic laterality

(2013) Laura N. Vandenberg et al.   DEVELOPMENTAL BIOLOGY

Drosophila Left/Right Asymmetry Establishment Is Controlled by the Hox Gene Abdominal-B

(2013) Jean-Baptiste Coutelis et al.   DEVELOPMENTAL CELL

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking

(2013) Martin D. Burkhalter et al.   Cell Reports

Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro

(2012) Xianghua Yan et al.   Autophagy

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Left–right asymmetry in zebrafish

(2012) Takaaki Matsui et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

 -Catenin 1 and  -catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos

(2012) M. Zhang et al.   DEVELOPMENT

Regional cell shape changes control form and function of Kupffer's vesicle in the zebrafish embryo

(2012) Guangliang Wang et al.   DEVELOPMENTAL BIOLOGY

Tuberous sclerosis in a patient with situs inversus totalis and polysplenia

(2012) Efstathios Rallis et al.   Indian Journal of Dermatology Venereology & Leprology

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

mTOR is required for asymmetric division through small GTPases in mouse oocytes

(2012) Seung-Eun Lee et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation

(2012) S. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2

(2012) S. Yoshiba et al.   SCIENCE

Two rotating cilia in the node cavity are sufficient to break left–right symmetry in the mouse embryo

(2012) Kyosuke Shinohara et al.   Nature Communications

IP3 signaling is required for cilia formation and left–right body axis determination in Xenopus embryos

(2011) Minoru Hatayama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum is a main localization site of mTORC2

(2011) Delphine R. Boulbés et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2

(2011) S. Field et al.   DEVELOPMENT

Left–right asymmetry in the level of active Nodal protein produced in the node is translated into left–right asymmetry in the lateral plate of mouse embryos

(2011) Aiko Kawasumi et al.   DEVELOPMENTAL BIOLOGY

Wdr18 Is Required for Kupffer's Vesicle Formation and Regulation of Body Asymmetry in Zebrafish

(2011) Wei Gao et al.   PLoS One

Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis

(2011) T. Matsui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

An Updated Overview on Wnt Signaling Pathways

(2010) Tata Purushothama Rao et al.   CIRCULATION RESEARCH

The activation of membrane targeted CaMK-II in the zebrafish Kupffer's vesicle is required for left-right asymmetry

(2010) L. Francescatto et al.   DEVELOPMENT

Chiral Forces Organize Left-Right Patterning in C. elegans by Uncoupling Midline and Anteroposterior Axis

(2010) Christian Pohl et al.   DEVELOPMENTAL CELL

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

(2010) Takeshi Kaizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disorders of left-right asymmetry: Heterotaxy and situs inversus

(2009) Mardi J. Sutherland et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor?

(2009) Melanie Philipp et al.   CURRENT BIOLOGY

Xenopus, an ideal model system to study vertebrate left-right asymmetry

(2009) Martin Blum et al.   DEVELOPMENTAL DYNAMICS

Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones

(2009) Seong Hwan Hwahng et al.   HEPATOLOGY

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

The orphan G protein-coupled receptor 161 is required for left–right patterning

(2008) TinChung Leung et al.   DEVELOPMENTAL BIOLOGY

Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway

(2008) Linda M. DiBella et al.   HUMAN MOLECULAR GENETICS

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

(2008) Tiffiney R. Hartman et al.   HUMAN MOLECULAR GENETICS

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Left–right asymmetry in Drosophila

(2008) J.B. Coutelis et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Perspectives and open problems in the early phases of left–right patterning

(2008) Laura N. Vandenberg et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY