Primary Cilia and Their Role in Acquired Heart Disease

Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer

(2021) Junguee Lee et al.   Scientific Reports

Biomarkers for heart failure and prognostic prediction in patients with Fontan circulation

(2021) Kei Inai   PEDIATRICS INTERNATIONAL

The ciliary impact of nonciliary gene mutations

(2021) Marta Lovera et al.   TRENDS IN CELL BIOLOGY

Identification of Cilia in Different Mouse Tissues

(2021) Xinhua Li et al.   Cells

Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles

(2021) Ann-Kathrin Volz et al.   Nature Communications

The Structural Biology of Septins and Their Filaments: An Update

(2021) Italo A. Cavini et al.   Frontiers in Cell and Developmental Biology

Clinical and Molecular Diagnosis of Joubert Syndrome and Related Disorders

(2020) Akella Radha Rama Devi et al.   PEDIATRIC NEUROLOGY

Diastolic Heart Failure in Patients With the Fontan Circulation

(2020) Werner Budts et al.   JAMA Cardiology

Regulation of the Extracellular Matrix by Ciliary Machinery

(2020) Collins I et al.   Cells

Role of cilia in the pathogenesis of congenital heart disease

(2020) George C. Gabriel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endothelial-specific Loss of IFT88 Promotes Endothelial-to-Mesenchymal Transition and Exacerbates Bleomycin-induced Pulmonary Fibrosis

(2020) Shweta Singh et al.   Scientific Reports

Predicting sudden cardiac death in adults with congenital heart disease

(2020) Jose M Oliver et al.   HEART

Disruption of endothelial cell intraflagellar transport protein 88 exacerbates doxorubicin-induced cardiotoxicity

(2020) Vincent Z. Luu et al.   LIFE SCIENCES

Proteomic Identification Reveals the Role of Ciliary Extracellular‐Like Vesicle in Cardiovascular Function

(2020) Ashraf M. Mohieldin et al.   Advanced Science

Crosstalk of Hedgehog and mTORC1 Pathways

(2020) Lasse Jonsgaard Larsen et al.   Cells

Survival in Children With Congenital Heart Disease: Have We Reached a Peak at 97%?

(2020) Zacharias Mandalenakis et al.   Journal of the American Heart Association

Fibroblast Primary Cilia are Required for Cardiac Fibrosis

(2019) Elisa Villalobos et al.   CIRCULATION

Structure and function of polycystins: insights into polycystic kidney disease

(2019) Dominique Douguet et al.   Nature Reviews Nephrology

Primary cilia defects causing mitral valve prolapse

(2019) Katelynn A. Toomer et al.   Science Translational Medicine

Collateral Vessels Have Unique Endothelial and Smooth Muscle Cell Phenotypes

(2019) Hua Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CiliaCarta: An integrated and validated compendium of ciliary genes

(2019) Teunis J. P. van Dam et al.   PLoS One

The Role of the Primary Cilium in Sensing Extracellular pH

(2019) Kimberly F. Atkinson et al.   Cells

Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis

(2019) Diana Fulmer et al.   CIRCULATION

The Autophagy-Cilia Axis: An Intricate Relationship

(2019) Morleo et al.   Cells

Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson’s disease model

(2019) Ji-Eun Bae et al.   Cell Death & Disease

Genetics of Congenital Heart Disease

(2019) Kylia Williams et al.   Biomolecules

Role of endothelial primary cilia as fluid mechanosensors on vascular health

(2018) Vincent Z. Luu et al.   ATHEROSCLEROSIS

CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog

(2018) Ganesh V. Pusapati et al.   DEVELOPMENTAL CELL

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

(2018) David K. Breslow et al.   NATURE GENETICS

Nephronophthisis: A review of genotype-phenotype correlation

(2018) Fenglan Luo et al.   NEPHROLOGY

Adult Congenital Heart Disease in a Nationwide Population 2000–2014: Epidemiological Trends, Arrhythmia, and Standardized Mortality Ratio

(2018) Mei‐Hwan Wu et al.   Journal of the American Heart Association

Myocardial Fibrosis in Patients With Primary Mitral Regurgitation With and Without Prolapse

(2018) Danai Kitkungvan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitral Valve Prolapse

(2018) Robert A. Levine et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Roles of Primary Cilia in Cardiovascular Diseases

(2018) Rajasekharreddy Pala et al.   Cells

Primary cilia: Cell and molecular mechanosensors directing whole tissue function

(2017) Milos Spasic et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

Meckel–Gruber Syndrome: An Update on Diagnosis, Clinical Management, and Research Advances

(2017) Verity Hartill et al.   Frontiers in Pediatrics

Congenital Heart Defects in the United StatesClinical Perspective

(2016) Suzanne M. Gilboa et al.   CIRCULATION

Endothelial primary cilia inhibit atherosclerosis

(2016) Colin Dinsmore et al.   EMBO REPORTS

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery

(2016) Michinori Toriyama et al.   NATURE GENETICS

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Getting to the Heart of the Matter

(2015) Andrew Leask   CIRCULATION RESEARCH

The Unnatural History of the Ventricular Septal Defect

(2015) Myrthe E. Menting et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mutations in DCHS1 cause mitral valve prolapse

(2015) Ronen Durst et al.   NATURE

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

(2015) You Li et al.   NATURE

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes

(2015) Gabrielle Wheway et al.   NATURE CELL BIOLOGY

Epidemiology and Pathophysiology of Mitral Valve Prolapse

(2014) Francesca N. Delling et al.   CIRCULATION

Oscillatory fluid flow influences primary cilia and microtubule mechanics

(2014) Lina C. Espinha et al.   Cytoskeleton

The primary cilium

(2014) Andrew M Fry et al.   Organogenesis

Alstrom Syndrome: Genetics and Clinical Overview

(2012) Jan D. Marshall et al.   CURRENT GENOMICS

The Extracellular Matrix Modulates Fibroblast Phenotype and Function in the Infarcted Myocardium

(2012) Marcin Dobaczewski et al.   Journal of Cardiovascular Translational Research

Use of Antihypertensive Medications and Mortality of Patients With Autosomal Dominant Polycystic Kidney Disease: A Population-Based Study

(2011) Christine Patch et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Clinical insights gained from eight new cases and review of reported cases with Jeune syndrome (asphyxiating thoracic dystrophy)

(2011) Kim M. Keppler-Noreuil et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition

(2011) Anastasia D. Egorova et al.   CIRCULATION RESEARCH

Dopamine Receptor Type 5 in the Primary Cilia Has Dual Chemo- and Mechano-Sensory Roles

(2011) Shakila Abdul-Majeed et al.   HYPERTENSION

Ciliopathies: an expanding disease spectrum

(2011) Aoife M. Waters et al.   PEDIATRIC NEPHROLOGY

Cranioectodermal Dysplasia, Sensenbrenner Syndrome, Is a Ciliopathy Caused by Mutations in the IFT122 Gene

(2010) Joanna Walczak-Sztulpa et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular diagnosis reveals genetic heterogeneity for the overlapping MKKS and BBS phenotypes

(2010) Elise Schaefer et al.   European Journal of Medical Genetics

Dopamine Receptors

(2010) Chunyu Zeng et al.   HYPERTENSION

The primary cilium at a glance

(2010) P. Satir et al.   JOURNAL OF CELL SCIENCE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Making sense of cilia in disease: The human ciliopathies

(2009) Kate Baker et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

(2009) Norifumi Takeda et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1

(2008) Surya M. Nauli et al.   CIRCULATION

Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis

(2007) Kim Van der Heiden et al.   ATHEROSCLEROSIS