Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis

Replacement Myocardial Fibrosis in Patients with Mitral Valve Prolapse: Relation to Mitral Regurgitation, Ventricular Remodeling and Arrhythmia

(2021) Anne-Laure Constant Dit Beaufils et al.   CIRCULATION

Desert Hedgehog-Primary Cilia Cross Talk Shapes Mitral Valve Tissue by Organizing Smooth Muscle Actin

(2020) Diana Fulmer et al.   DEVELOPMENTAL BIOLOGY

A novel cross-species model of Barlow’s disease to biomechanically analyze repair techniques in an ex vivo left heart simulator

(2020) Annabel M. Imbrie-Moore et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord

(2020) Jun Zhang et al.   Nature Communications

Connexin-43 reduction prevents muscle defects in a mouse model of manifesting Duchenne muscular dystrophy female carriers

(2020) Julie Nouet et al.   Scientific Reports

Systematic quantification of histologic ventricular fibrosis in isolated mitral valve prolapse and sudden cardiac death

(2020) Hui-Chen Han et al.   HEART RHYTHM

Atrial Fibrillation and Mitral Valve Prolapse

(2019) Michael A. Borger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Left ventricular mechanical dispersion predicts arrhythmic risk in mitral valve prolapse

(2019) Simon Ermakov et al.   HEART

Fibroblast Primary Cilia are Required for Cardiac Fibrosis

(2019) Elisa Villalobos et al.   CIRCULATION

Primary cilia defects causing mitral valve prolapse

(2019) Katelynn A. Toomer et al.   Science Translational Medicine

Connexin-43-dependent ATP release mediates macrophage activation during sepsis

(2019) Michel Dosch et al.   eLife

Disruption of Ca 2+ i Homeostasis and Cx43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in PKP2-Deficient Mice

(2019) Joon-Chul Kim et al.   CIRCULATION

Genome-Wide Association Study–Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse

(2019) Mengyao Yu et al.   Circulation-Genomic and Precision Medicine

Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis

(2019) Diana Fulmer et al.   CIRCULATION

Long-Term Results of Mitral Valve Repair for Regurgitation Due to Leaflet Prolapse

(2019) Tirone E. David et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury

(2019) Jingbo Jiang et al.   Journal of the American Heart Association

P3500The primary cilium, a sensory apparatus of cells regulates the profibrotic capacity of fibroblasts in atrial fibrillation

(2019) M Kawasaki et al.   EUROPEAN HEART JOURNAL

Mitral chordae tendineae force profile characterization using a posterior ventricular anchoring neochordal repair model for mitral regurgitation in a three-dimensional-printed ex vivo left heart simulator

(2019) Michael J Paulsen et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation

(2018) Marika Milan et al.   Cell Death & Disease

The Mitral Annulus Disjunction Arrhythmic Syndrome

(2018) Lars A. Dejgaard et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myocardial Fibrosis in Patients With Primary Mitral Regurgitation With and Without Prolapse

(2018) Danai Kitkungvan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Filamin-A as a Balance between Erk/Smad Activities During Cardiac Valve Development

(2018) Katelynn Toomer et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Arrhythmic Mitral Valve Prolapse

(2018) Marc A. Miller et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Measuring chordae tension during transapical neochordae implantation: Toward understanding objective consequences of mitral valve repair

(2018) Daniel Grinberg et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

2017 ESC/EACTS Guidelines for the management of valvular heart disease

(2017) Helmut Baumgartner et al.   EUROPEAN HEART JOURNAL

IL11 is a crucial determinant of cardiovascular fibrosis

(2017) Sebastian Schafer et al.   NATURE

The primary cilium is necessary for the differentiation and the maintenance of human adipose progenitors into myofibroblasts

(2017) N. Arrighi et al.   Scientific Reports

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Diffuse myocardial fibrosis in patients with mitral valve prolapse and ventricular arrhythmia

(2016) An H Bui et al.   HEART

A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation

(2016) A.C. Zeigler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanical control of cardiac myofibroblasts

(2016) Sander van Putten et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

(2016) Robert G. Gourdie et al.   NATURE REVIEWS DRUG DISCOVERY

IFT88 influences chondrocyte actin organization and biomechanics

(2016) Z. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

TGFβ1 – induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner

(2016) Marie-Noëlle Labour et al.   Scientific Reports

Arrhythmic Mitral Valve Prolapse and Sudden Cardiac DeathCLINICAL PERSPECTIVE

(2015) Cristina Basso et al.   CIRCULATION

TGF-β Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells

(2015) Makiri Kawasaki et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mutations in DCHS1 cause mitral valve prolapse

(2015) Ronen Durst et al.   NATURE

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

(2015) Christian Dina et al.   NATURE GENETICS

Mitral valve disease—morphology and mechanisms

(2015) Robert A. Levine et al.   Nature Reviews Cardiology

Inhibition of Connexin 43 Hemichannel-Mediated ATP Release Attenuates Early Inflammation During the Foreign Body Response

(2015) Bennett W. Calder et al.   TISSUE ENGINEERING PART A

Mechanobiology of Ciliogenesis

(2014) Hiroaki Ishikawa et al.   BIOSCIENCE

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

Left ventricular dysfunction after mitral valve repair—the fallacy of “normal” preoperative myocardial function

(2014) Eduard Quintana et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

(2013) Christian Alexandro Clement et al.   Cell Reports

The extracellular matrix and ciliary signaling

(2012) Tamina Seeger-Nukpezah et al.   CURRENT OPINION IN CELL BIOLOGY

ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors

(2012) David Lu et al.   FASEB JOURNAL

Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of Hsp27 dependent actin cytoskeletal organization

(2011) Thomas J. Jones et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation

(2010) S. Mangos et al.   Disease Models & Mechanisms