The circadian clock and extracellular matrix homeostasis in aging and age-related diseases

Hallmarks of aging: An expanding universe

(2023) Carlos López-Otín et al.   CELL

Defining the age-dependent and tissue-specific circadian transcriptome in male mice

(2023) Christopher A. Wolff et al.   Cell Reports

Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells

(2023) Jack Llewellyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrikines as mediators of tissue remodelling

(2022) Nathan Jariwala et al.   ADVANCED DRUG DELIVERY REVIEWS

Circadian molecular clock disruption in chronic pulmonary diseases

(2022) Allan Giri et al.   TRENDS IN MOLECULAR MEDICINE

Circadian regulation of protein cargo in extracellular vesicles

(2022) Ching-Yan Chloé Yeung et al.   Science Advances

YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING

(2022) Hanna Lucie Sladitschek-Martens et al.   NATURE

The actin cytoskeleton-MRTF/SRF cascade transduces cellular physical niche cues to entrain the circadian clock

(2022) Xuekai Xiong et al.   JOURNAL OF CELL SCIENCE

Understanding light pollution: Recent advances on its health threats and regulations

(2022) Miao Cao et al.   Journal of Environmental Sciences-China

Peripheral clocks tick independently of their master

(2021) Anna-Marie Finger et al.   GENES & DEVELOPMENT

The phosphorylation switch that regulates ticking of the circadian clock

(2021) Rajesh Narasimamurthy et al.   MOLECULAR CELL

Circadian time series proteomics reveals daily dynamics in cartilage physiology

(2021) M. Dudek et al.   OSTEOARTHRITIS AND CARTILAGE

Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis

(2021) Yuya Yoshida et al.   Nature Communications

Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology

(2021) Moisés Selman et al.   AGEING RESEARCH REVIEWS

Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

(2021) Anna-Marie Finger et al.   Science Advances

Excessive mechanical strain accelerates intervertebral disc degeneration by disrupting intrinsic circadian rhythm

(2021) Sheng-Long Ding et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

(2021) Yoanna Ariosa-Morejon et al.   eLife

Circadian control of the secretory pathway maintains collagen homeostasis

(2020) Joan Chang et al.   NATURE CELL BIOLOGY

Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice

(2020) Hitoshi Inokawa et al.   Scientific Reports

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

(2020) Erika Kelmer Sacramento et al.   Molecular Systems Biology

Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

(2020) Eva Hadadi et al.   Nature Communications

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

(2020) Kaj E.C. Blokland et al.   CLINICAL SCIENCE

Chronic circadian shift leads to adipose tissue inflammation and fibrosis

(2020) Xuekai Xiong et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression

(2019) S. Khurana et al.   OSTEOARTHRITIS AND CARTILAGE

Circadian rhythms in skin and other elastic tissues

(2019) Michael J. Sherratt et al.   MATRIX BIOLOGY

Understanding Multicellularity: The Functional Organization of the Intercellular Space

(2019) Leonardo Bich et al.   Frontiers in Physiology

Molecular mechanisms and physiological importance of circadian rhythms

(2019) Alina Patke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

(2019) Peter S. Cunningham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of matricellular proteins and tissue stiffness in breast cancer: a systematic review

(2018) Sirio Fiorino et al.   Future Oncology

Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment

(2018) Jack Williams et al.   JOURNAL OF CELL SCIENCE

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

(2018) Mark G Jones et al.   eLife

The aging clock: circadian rhythms and later life

(2017) Suzanne Hood et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes

(2017) R. Akagi et al.   OSTEOARTHRITIS AND CARTILAGE

Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing

(2017) Nathaniel P. Hoyle et al.   Science Translational Medicine

Cellular mechano-environment regulates the mammary circadian clock

(2017) Nan Yang et al.   Nature Communications

Physiological links of circadian clock and biological clock of aging

(2017) Fang Liu et al.   Protein & Cell

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

(2017) Kelly L. Walton et al.   Frontiers in Pharmacology

The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

(2016) Michal Dudek et al.   ANNALS OF THE RHEUMATIC DISEASES

The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis

(2016) Sarah J. B. Snelling et al.   CHRONOBIOLOGY INTERNATIONAL

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Circadian misalignment increases cardiovascular disease risk factors in humans

(2016) Christopher J. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

(2016) Guangrui Yang et al.   Science Translational Medicine

Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound

(2016) Lauren E. Tracy et al.   Advances in Wound Care

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

(2016) Yuliya V. Dubrovsky et al.   Aging-US

BMAL1-dependent regulation of the mTOR signaling pathway delays aging

(2016) Rohini V. Khapre et al.   Aging-US

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation

(2015) Jonathan O. Lipton et al.   CELL

Circadian desynchronization triggers premature cellular aging in a diurnal rodent

(2015) Edith Grosbellet et al.   FASEB JOURNAL

Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint

(2015) Ranjan Kc et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome

(2015) Atish Mukherji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis

(2015) Manando Nakasaki et al.   Nature Communications

Shift work and its association with metabolic disorders

(2015) Maria Carlota Borba Brum et al.   Diabetology & Metabolic Syndrome

Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

(2015) Andrew M Handorf et al.   Organogenesis

Targeting ECM Disrupts Cancer Progression

(2015) Freja A. Venning et al.   Frontiers in Oncology

Differential modulation of clock gene expression in the suprachiasmatic nucleus, liver and heart of aged mice

(2014) Marta Bonaconsa et al.   EXPERIMENTAL GERONTOLOGY

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

(2014) V. Pekovic-Vaughan et al.   GENES & DEVELOPMENT

Evidence That Breast Tissue Stiffness Is Associated with Risk of Breast Cancer

(2014) Norman F. Boyd et al.   PLoS One

A central role for ubiquitination within a circadian clock protein modification code

(2014) Katarina Stojkovic et al.   Frontiers in Molecular Neuroscience

The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis

(2013) Nicole Gossan et al.   ARTHRITIS AND RHEUMATISM

Breast cancer and circadian disruption from electric lighting in the modern world

(2013) Richard G. Stevens et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Biological Rhythms During Residence in Polar Regions

(2012) Josephine Arendt   CHRONOBIOLOGY INTERNATIONAL

Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks

(2012) Urs Albrecht   NEURON

The extracellular matrix: an active or passive player in fibrosis?

(2011) Thomas N. Wight et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Shift work and chronic disease: the epidemiological evidence

(2011) X.-S. Wang et al.   OCCUPATIONAL MEDICINE-OXFORD

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Low Bone Mineral Density in Rotating-Shift Workers

(2010) Ivan Quevedo et al.   JOURNAL OF CLINICAL DENSITOMETRY

The Evolution of Extracellular Matrix

(2010) Suat Özbek et al.   MOLECULAR BIOLOGY OF THE CELL

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Tissue elasticity and the ageing elastic fibre

(2009) Michael J. Sherratt   AGE

Incidence of metabolic syndrome among night-shift healthcare workers

(2009) A Pietroiusti et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Adverse metabolic and cardiovascular consequences of circadian misalignment

(2009) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Circadian Loop asSIRTs Itself

(2009) H. Wijnen   SCIENCE

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Nightshift work and fracture risk: the Nurses’ Health Study

(2008) D. Feskanich et al.   OSTEOPOROSIS INTERNATIONAL