Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract

(2015) H T Morris et al.   BRITISH JOURNAL OF CANCER

Age-related changes in dynamic compressive properties of trochanteric soft tissues over the hip

(2015) W.J. Choi et al.   JOURNAL OF BIOMECHANICS

Integrins in periodontal disease

(2014) Hannu Larjava et al.   EXPERIMENTAL CELL RESEARCH

EPCs in vascular repair: How can we clear the hurdles between bench and bedside?

(2014) Chenhui Lu   Frontiers in Bioscience-Landmark

Selective regulation of cytoskeletal tension and cell–matrix adhesion by RhoA and Src

(2014) Harini Sreenivasappa et al.   Integrative Biology

Mechanical regulation of mesenchymal stem cell differentiation

(2014) Andrew J. Steward et al.   JOURNAL OF ANATOMY

Intrinsic stiffness of extracellular matrix increases with age in skeletal muscles of mice

(2014) Lauren K. Wood et al.   JOURNAL OF APPLIED PHYSIOLOGY

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling

(2014) Y. H. Bae et al.   Science Signaling

Matrix Metalloproteinases: Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling

(2013) Qishan Chen et al.   MEDIATORS OF INFLAMMATION

p21-Activated kinase (PAK) is required for Bone Morphogenetic Protein (BMP)-induced dendritogenesis in cortical neurons

(2013) Monika Podkowa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

In situ chondrocyte viscoelasticity

(2012) Sang-Kuy Han et al.   JOURNAL OF BIOMECHANICS

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration

(2011) J. Huynh et al.   Science Translational Medicine

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

CD44, a therapeutic target for metastasising tumours

(2010) Véronique Orian-Rousseau   EUROPEAN JOURNAL OF CANCER

NPA motifs play a key role in plasma membrane targeting of aquaporin-4

(2010) Xin-Gang Guan et al.   IUBMB LIFE

Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells

(2010) Yu-Ru V Shih et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The dual kinase complex FAK-Src as a promising therapeutic target in cancer

(2010) Victoria Bolós   OncoTargets and Therapy

The Regulative Role of Neurite Mechanical Tension in Network Development

(2009) Sarit Anava et al.   BIOPHYSICAL JOURNAL

A Stiff Blow from the Stroma: Collagen Crosslinking Drives Tumor Progression

(2009) Mei Rosa Ng et al.   CANCER CELL

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

(2009) Trista E. North et al.   CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

Actomyosin stiffens the vertebrate embryo during crucial stages of elongation and neural tube closure

(2009) J. Zhou et al.   DEVELOPMENT

Apical constriction: A cell shape change that can drive morphogenesis

(2009) Jacob M. Sawyer et al.   DEVELOPMENTAL BIOLOGY

Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate

(2009) Joy Kahn et al.   DEVELOPMENTAL CELL

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Vascular endothelial growth factor and substrate mechanics regulate in vitro tubulogenesis of endothelial progenitor cells

(2009) Donny Hanjaya-Putra et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Biomechanical forces promote embryonic haematopoiesis

(2009) Luigi Adamo et al.   NATURE

An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos

(2009) Bruno Monier et al.   NATURE CELL BIOLOGY

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Heparanase involvement in physiology and disease

(2008) N. J. Nasser   CELLULAR AND MOLECULAR LIFE SCIENCES

Three-dimensional context regulation of metastasis

(2008) Janine T. Erler et al.   CLINICAL & EXPERIMENTAL METASTASIS

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

(2008) Karl E Kadler et al.   CURRENT OPINION IN CELL BIOLOGY

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

(2008) Jordi Alcaraz et al.   EMBO JOURNAL

ECM Compliance Regulates Osteogenesis by Influencing MAPK Signaling Downstream of RhoA and ROCK

(2008) Chirag B Khatiwala et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanoenzymatics of titin kinase

(2008) E. M. Puchner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular matrix mechanics in lung parenchymal diseases

(2008) Béla Suki et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Collective Cell Migration Drives Morphogenesis of the Kidney Nephron

(2008) Aleksandr Vasilyev et al.   PLOS BIOLOGY