Molecular mechanisms and physiological importance of circadian rhythms

The arrival of circadian medicine

(2019) Satchidananda Panda   Nature Reviews Endocrinology

Cell-autonomous clock of astrocytes drives circadian behavior in mammals

(2019) Marco Brancaccio et al.   SCIENCE

The circadian E3 ligase complex SCFFBXL3+CRY targets TLK2

(2019) Stephanie Papp Correia et al.   Scientific Reports

O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression

(2019) Ying H. Li et al.   PLoS Genetics

A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila

(2019) Hirofumi Toda et al.   SCIENCE

PERIOD-controlled deadenylation of thetimelesstranscript in theDrosophilacircadian clock

(2019) Brigitte Grima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clock protein Rev-erbα regulates neuroinflammation

(2019) Percy Griffin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer–enhancer interactions

(2019) Joshua R. Beytebiere et al.   GENES & DEVELOPMENT

Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals

(2019) Yaarit Adamovich et al.   Cell Metabolism

Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

(2019) Priya Crosby et al.   CELL

Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity

(2019) Fangke Xu et al.   Cell Reports

Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice

(2019) Ben J. Greenwell et al.   Cell Reports

MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle

(2019) Brian A Hodge et al.   eLife

Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

(2019) Nikolai Petkau et al.   eLife

A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux

(2018) Shirley L. Zhang et al.   CELL

Clock-dependent chromatin topology modulates circadian transcription and behavior

(2018) Jérôme Mermet et al.   GENES & DEVELOPMENT

Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment

(2018) Jack Williams et al.   JOURNAL OF CELL SCIENCE

Role of the circadian system in cardiovascular disease

(2018) Saurabh S. Thosar et al.   JOURNAL OF CLINICAL INVESTIGATION

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study

(2018) David Montaigne et al.   LANCET

Circadian clock neurons constantly monitor environmental temperature to set sleep timing

(2018) Swathi Yadlapalli et al.   NATURE

Generation of circadian rhythms in the suprachiasmatic nucleus

(2018) Michael H. Hastings et al.   NATURE REVIEWS NEUROSCIENCE

The neurobiological basis of sleep: Insights from Drosophila

(2018) Sarah Ly et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Underlying Genetics of Drosophila Circadian Behaviors

(2018) D. Lorena Franco et al.   PHYSIOLOGY

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

(2018) Rajesh Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription

(2018) Yong Hoon Kim et al.   SCIENCE

Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

(2018) Ludovic S. Mure et al.   SCIENCE

Prospects for Circadian Treatment of Mood Disorders

(2018) Anisja Hühne et al.   ANNALS OF MEDICINE

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain

(2018) Anna N. King et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Closely Related Fruit Fly Species Living at Different Latitudes Diverge in Their Circadian Clock Anatomy and Rhythmic Behavior

(2018) Marta Beauchamp et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

(2018) Gabriele Sulli et al.   NATURE

A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

(2018) Marc D. Ruben et al.   Science Translational Medicine

Circadian rhythmicity persists through the Polar night and midnight sun in Svalbard reindeer

(2018) Walter Arnold et al.   Scientific Reports

Nighttime activities and peripheral clock oscillations depend on Wolbachia endosymbionts in flies

(2018) Eri Morioka et al.   Scientific Reports

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks

(2018) Meng Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

(2018) JingJing Liu et al.   Science Signaling

JMJD5 links CRY1 function and proteasomal degradation

(2018) Anand R. Saran et al.   PLOS BIOLOGY

Circadian Rhythms and Sleep in Drosophila melanogaster

(2017) Christine Dubowy et al.   GENETICS

Transcription factor activity rhythms and tissue-specific chromatin interactions explain circadian gene expression across organs

(2017) Jake Yeung et al.   GENOME RESEARCH

Macromolecular Assemblies of the Mammalian Circadian Clock

(2017) Rajindra P. Aryal et al.   MOLECULAR CELL

Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1

(2017) Koji L. Ode et al.   MOLECULAR CELL

A rhodopsin in the brain functions in circadian photoentrainment in Drosophila

(2017) Jinfei D. Ni et al.   NATURE

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling

(2017) Marco Brancaccio et al.   NEURON

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity

(2017) Anna Kriebs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox-sensitive alteration of replisome architecture safeguards genome integrity

(2017) Kumar Somyajit et al.   SCIENCE

Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing

(2017) Nathaniel P. Hoyle et al.   Science Translational Medicine

Cellular mechano-environment regulates the mammary circadian clock

(2017) Nan Yang et al.   Nature Communications

Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila

(2017) Mareike Selcho et al.   Nature Communications

Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging

(2017) Rachael C. Kuintzle et al.   Nature Communications

FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice

(2017) Arisa Hirano et al.   Cell Reports

Transcriptional regulatory logic of the diurnal cycle in the mouse liver

(2017) Jonathan Aryeh Sobel et al.   PLOS BIOLOGY

Bmal1 function in skeletal muscle regulates sleep

(2017) J Christopher Ehlen et al.   eLife

Circadian Rhythms and Sleep in Drosophila melanogaster

(2017) Christine Dubowy et al.   GENETICS

Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts

(2017) Ayako Shinozaki et al.   PLoS One

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents

(2016) Paul S. Humphries et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

(2016) Xuan Zhao et al.   CELL

The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure

(2016) Ricardo Orozco-Solis et al.   Cell Metabolism

Dietary Restriction Extends the Lifespan of Circadian Mutants tim and per

(2016) Matt Ulgherait et al.   Cell Metabolism

Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila

(2016) Subhash D. Katewa et al.   Cell Metabolism

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

The Circadian Clock Is a Key Driver of Steroid Hormone Production in Drosophila

(2016) Francesca Di Cara et al.   CURRENT BIOLOGY

The Circadian Clock and Human Health

(2016) Till Roenneberg et al.   CURRENT BIOLOGY

Conditional Deletion ofBmal1in Ovarian Theca Cells Disrupts Ovulation in Female Mice

(2016) Amanda L. Mereness et al.   ENDOCRINOLOGY

HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms

(2016) Yuxiang Zhang et al.   GENES & DEVELOPMENT

Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells

(2016) Annika F. Barber et al.   GENES & DEVELOPMENT

Circadian Transcription from Beta Cell Function to Diabetes Pathophysiology

(2016) Mark Perelis et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Life in a dark biosphere: a review of circadian physiology in “arrhythmic” environments

(2016) Andrew David Beale et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

CRY2 and FBXL3 Cooperatively Degrade c-MYC

(2016) Anne-Laure Huber et al.   MOLECULAR CELL

Circadian neuron feedback controls the Drosophila sleep–activity profile

(2016) Fang Guo et al.   NATURE

Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression

(2016) Ariadna Amador et al.   PLoS One

mir-276a strengthensDrosophilacircadian rhythms by regulatingtimelessexpression

(2016) Xiao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Period represses and de-represses transcription by displacing CLOCK–BMAL1 from promoters in a Cryptochrome-dependent manner

(2016) Yi-Ying Chiou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clocks: Not your grandfather’s clock

(2016) Fred W. Turek   SCIENCE

Synchronous Drosophila circadian pacemakers display nonsynchronous Ca2+ rhythms in vivo

(2016) X. Liang et al.   SCIENCE

Circadian Rhythms, Sleep, and Disorders of Aging

(2016) Joanna Mattis et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

(2016) Anton Shostak et al.   Nature Communications

Sensory Conflict Disrupts Activity of the Drosophila Circadian Network

(2016) Ross E.F. Harper et al.   Cell Reports

The Drosophila Clock Neuron Network Features Diverse Coupling Modes and Requires Network-wide Coherence for Robust Circadian Rhythms

(2016) Zepeng Yao et al.   Cell Reports

GSK-3 and CK2 Kinases Converge on Timeless to Regulate the Master Clock

(2016) Deniz Top et al.   Cell Reports

NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators

(2016) Dominic Landgraf et al.   PLoS Genetics

Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue

(2016) Renske Erion et al.   eLife

A Cryptochrome 2 mutation yields advanced sleep phase in humans

(2016) Arisa Hirano et al.   eLife

Heterogeneity of the Peripheral Circadian Systems in Drosophila melanogaster: A Review

(2016) Chihiro Ito et al.   Frontiers in Physiology

The circadian clock gene period extends healthspan in aging Drosophila melanogaster

(2016) Natraj Krishnan et al.   Aging-US

Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1

(2016) Roman V. Kondratov et al.   Aging-US

CH Activation Generates Period-Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock

(2015) Tsuyoshi Oshima et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells

(2015) Sung Kook Chun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

Flies Remember the Time of Day

(2015) Nitin S. Chouhan et al.   CURRENT BIOLOGY

The cardiomyocyte molecular clock regulates the circadian expression of Kcnh2 and contributes to ventricular repolarization

(2015) Elizabeth A. Schroder et al.   HEART RHYTHM

The Circadian Clock in the Regulation of Renal Rhythms

(2015) Kristen Solocinski et al.   JOURNAL OF BIOLOGICAL RHYTHMS

A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function

(2015) Anandakrishnan Venkatesan et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Circadian Clocks in the Immune System

(2015) Nathalie Labrecque et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Evening Chronotype Is Associated With Metabolic Disorders and Body Composition in Middle-Aged Adults

(2015) Ji Hee Yu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cancer/Testis Antigen PASD1 Silences the Circadian Clock

(2015) Alicia K. Michael et al.   MOLECULAR CELL

A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period

(2015) Min Zhou et al.   MOLECULAR CELL

Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature

(2015) Chenghao Chen et al.   NATURE

Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior

(2015) Jeff R Jones et al.   NATURE NEUROSCIENCE

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Natural selection against a circadian clock gene mutation in mice

(2015) Kamiel Spoelstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock

(2015) Jason P. DeBruyne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time-restricted feeding attenuates age-related cardiac decline in Drosophila

(2015) S. Gill et al.   SCIENCE

Discrete functions of nuclear receptor Rev-erb  couple metabolism to the clock

(2015) Y. Zhang et al.   SCIENCE

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

KLF15 Establishes the Landscape of Diurnal Expression in the Heart

(2015) Lilei Zhang et al.   Cell Reports

Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale

(2015) Guang-Zhong Wang et al.   Cell Reports

CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock

(2015) Teruya Tamaru et al.   PLOS BIOLOGY

Drosophila Spaghetti and Doubletime Link the Circadian Clock and Light to Caspases, Apoptosis and Tauopathy

(2015) John C. Means et al.   PLoS Genetics

Drosophila TIM Binds Importin α1, and Acts as an Adapter to Transport PER to the Nucleus

(2015) A. Reum Jang et al.   PLoS Genetics

Aging alters circadian regulation of redox in Drosophila

(2015) Vladimir I. Klichko et al.   Frontiers in Genetics

Social jetlag, obesity and metabolic disorder: investigation in a cohort study

(2015) M J Parsons et al.   INTERNATIONAL JOURNAL OF OBESITY

Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation

(2014) Sooyoung Chung et al.   CELL

Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

(2014) Bin Fang et al.   CELL

Circadian Pacemaker Neurons Change Synaptic Contacts across the Day

(2014) E. Axel Gorostiza et al.   CURRENT BIOLOGY

The Logic of Circadian Organization in Drosophila

(2014) Stephane Dissel et al.   CURRENT BIOLOGY

Calcitonin Gene-Related Peptide Neurons Mediate Sleep-Specific Circadian Output in Drosophila

(2014) Michael Kunst et al.   CURRENT BIOLOGY

Circadian disruption in the pathogenesis of metabolic syndrome

(2014) E. Maury et al.   DIABETES & METABOLISM

CLOCK:BMAL1 is a pioneer-like transcription factor

(2014) J. S. Menet et al.   GENES & DEVELOPMENT

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

(2014) Rui Ye et al.   GENES & DEVELOPMENT

Gene Model 129 (Gm129) Encodes a Novel Transcriptional Repressor That Modulates Circadian Gene Expression

(2014) Yunus Annayev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is Social Jetlag Associated with an Adverse Endocrine, Behavioral, and Cardiovascular Risk Profile?

(2014) Femke Rutters et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Cardiomyocyte-Specific BMAL1 Plays Critical Roles in Metabolism, Signaling, and Maintenance of Contractile Function of the Heart

(2014) Martin E. Young et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

(2014) Hao A Duong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

WIDE AWAKE Mediates the Circadian Timing of Sleep Onset

(2014) Sha Liu et al.   NEURON

The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor

(2014) Nicole C. Gossan et al.   NUCLEIC ACIDS RESEARCH

Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness

(2014) Anne-Marie Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mechanosensory Pathway to the Drosophila Circadian Clock

(2014) A. Simoni et al.   SCIENCE

The Drosophila Circadian Clock Is a Variably Coupled Network of Multiple Peptidergic Units

(2014) Z. Yao et al.   SCIENCE

Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour

(2014) Subhashis Banerjee et al.   Nature Communications

Regulation of Drosophila circadian rhythms by miRNA let-7 is mediated by a regulatory cycle

(2014) Wenfeng Chen et al.   Nature Communications

The Role of the Endocrine System in Feeding-Induced Tissue-Specific Circadian Entrainment

(2014) Miho Sato et al.   Cell Reports

Machine Learning Helps Identify CHRONO as a Circadian Clock Component

(2014) Ron C. Anafi et al.   PLOS BIOLOGY

A Novel Protein, CHRONO, Functions as a Core Component of the Mammalian Circadian Clock

(2014) Akihiro Goriki et al.   PLOS BIOLOGY

Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount

(2014) Mi Shi et al.   eLife

Differential effects of light and feeding on circadian organization of peripheral clocks in a forebrain Bmal1 mutant

(2014) Mariko Izumo et al.   eLife

Cryptochromerestores dampened circadian rhythms and promotes healthspan in agingDrosophila

(2013) Kuntol Rakshit et al.   AGING CELL

The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility

(2013) Elizabeth A. Schroder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity

(2013) Alan Gerber et al.   CELL

Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

(2013) Krista Kaasik et al.   Cell Metabolism

Associations of Chronotype and Sleep With Cardiovascular Diseases and Type 2 Diabetes

(2013) Ilona Merikanto et al.   CHRONOBIOLOGY INTERNATIONAL

A role for clock genes in sleep homeostasis

(2013) Paul Franken   CURRENT OPINION IN NEUROBIOLOGY

Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length

(2013) Peng Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pigment-Dispersing Factor Modulates Pheromone Production in Clock Cells that Influence Mating in Drosophila

(2013) Joshua J. Krupp et al.   NEURON

Noncanonical FK506-Binding Protein BDBT Binds DBT to Enhance Its Circadian Function and Forms Foci at Night

(2013) Jin-Yuan Fan et al.   NEURON

The circadian system: Plasticity at many levels

(2013) N.I. Muraro et al.   NEUROSCIENCE

Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice

(2013) Y. Yabuki et al.   NEUROSCIENCE

Mammalian TIMELESS Is Involved in Period Determination and DNA Damage-Dependent Phase Advancing of the Circadian Clock

(2013) Erik Engelen et al.   PLoS One

ATAXIN-2 Activates PERIOD Translation to Sustain Circadian Rhythms in Drosophila

(2013) C. Lim et al.   SCIENCE

A Role for Drosophila ATX2 in Activation of PER Translation and Circadian Behavior

(2013) Y. Zhang et al.   SCIENCE

Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice

(2013) Kazuhiro Shimomura et al.   eLife

Glia-related circadian plasticity in the visual system of Diptera

(2013) Jolanta Górska-Andrzejak   Frontiers in Physiology

Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations

(2012) Wenyu Luo et al.   AGING CELL

Social Jetlag and Obesity

(2012) Till Roenneberg et al.   CURRENT BIOLOGY

Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators

(2012) C. Saini et al.   GENES & DEVELOPMENT

A role for O-GlcNAcylation in setting circadian clock speed

(2012) E. Y. Kim et al.   GENES & DEVELOPMENT

Deep sequencing the circadian and diurnal transcriptome of Drosophila brain

(2012) M. E. Hughes et al.   GENOME RESEARCH

Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function

(2012) Sanjoy K. Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clock accuracy and precision evolve as a consequence of selection for adult emergence in a narrow window of time in fruit flies Drosophila melanogaster

(2012) N. N. Kannan et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Persistence, reticence and the management of multiple time memories by forager honey bees

(2012) A. E. Wagner et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Scheduled Exercise Phase Shifts the Circadian Clock in Skeletal Muscle

(2012) GRETCHEN WOLFF et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

(2012) Laura A. Solt et al.   NATURE

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

(2012) Darwin Jeyaraj et al.   NATURE

Peroxiredoxins are conserved markers of circadian rhythms

(2012) Rachel S. Edgar et al.   NATURE

Lithium Impacts on the Amplitude and Period of the Molecular Circadian Clockwork

(2012) Jian Li et al.   PLoS One

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

(2012) Laura M. Beaver et al.   PLoS One

Toward the Beginning of Time: Circadian Rhythms in Metabolism Precede Rhythms in Clock Gene Expression in Mouse Embryonic Stem Cells

(2012) Jiffin K. Paulose et al.   PLoS One

Coordination of the transcriptome and metabolome by the circadian clock

(2012) K. L. Eckel-Mahan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

(2012) M. Geyfman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Sleep by Cyclin A and Its Regulator

(2012) D. Rogulja et al.   SCIENCE

Cold-Inducible RNA-Binding Protein Modulates Circadian Gene Expression Posttranscriptionally

(2012) J. Morf et al.   SCIENCE

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites

(2012) Jean-Michel Fustin et al.   Cell Reports

The Circadian Clock Protein Timeless Regulates Phagocytosis of Bacteria in Drosophila

(2012) Elizabeth F. Stone et al.   PLoS Pathogens

Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

(2012) Jerome S Menet et al.   eLife

The Cryptochromes: Blue Light Photoreceptors in Plants and Animals

(2011) Inês Chaves et al.   Annual Review of Plant Biology

The Circadian Clock Interacts with Metabolic Physiology to Influence Reproductive Fitness

(2011) Kanyan Xu et al.   Cell Metabolism

Depression Scores Associate With Chronotype and Social Jetlag in a Rural Population

(2011) Rosa Levandovski et al.   CHRONOBIOLOGY INTERNATIONAL

NEMO Kinase Contributes to Core Period Determination by Slowing the Pace of the Drosophila Circadian Oscillator

(2011) Wangjie Yu et al.   CURRENT BIOLOGY

Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock

(2011) Rui Ye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Refeeding after Fasting Elicits Insulin-Dependent Regulation of Per2 and Rev-erbα with Shifts in the Liver Clock

(2011) Yu Tahara et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

(2011) Katja A. Lamia et al.   NATURE

The novel gene twenty-four defines a critical translational step in the Drosophila clock

(2011) Chunghun Lim et al.   NATURE

Loss of circadian clock accelerates aging in neurodegeneration-prone mutants

(2011) Natraj Krishnan et al.   NEUROBIOLOGY OF DISEASE

insomniac and Cullin-3 Regulate Sleep and Wakefulness in Drosophila

(2011) Nicholas Stavropoulos et al.   NEURON

Synchronization of Circadian Per2 Rhythms and HSF1-BMAL1:CLOCK Interaction in Mouse Fibroblasts after Short-Term Heat Shock Pulse

(2011) Teruya Tamaru et al.   PLoS One

Control of skin cancer by the circadian rhythm

(2011) S. Gaddameedhi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity Rhythm ofDrosophilaKept in Complete Darkness for 1300 Generations

(2011) Michio Imafuku et al.   ZOOLOGICAL SCIENCE

Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB

(2010) Douglas Kojetin et al.   ACS Chemical Biology

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

(2010) David K. Welsh et al.   Annual Review of Physiology

A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

(2010) Yoshimi Uchida et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited

(2010) C. A. Wyse et al.   Biology Letters

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

(2010) Gad Asher et al.   CELL

Clock and cycle Limit Starvation-Induced Sleep Loss in Drosophila

(2010) Alex C. Keene et al.   CURRENT BIOLOGY

Regulation of Gustatory Physiology and Appetitive Behavior by the Drosophila Circadian Clock

(2010) Abhishek Chatterjee et al.   CURRENT BIOLOGY

Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA

(2010) J. S. Menet et al.   GENES & DEVELOPMENT

Cryptochrome-Positive and -Negative Clock Neurons in Drosophila Entrain Differentially to Light and Temperature

(2010) Taishi Yoshii et al.   JOURNAL OF BIOLOGICAL RHYTHMS

The Circadian Clock Starts Ticking at a Developmentally Early Stage

(2010) Elzbieta Kowalska et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin

(2010) Li-Tao Yi et al.   PHYSIOLOGY & BEHAVIOR

Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation

(2010) Saurabh Sahar et al.   PLoS One

Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila

(2010) E. Kula-Eversole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro

(2010) Kazuhiro Yagita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb 

(2010) L. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

Light-Dependent Interactions between the Drosophila Circadian Clock Factors Cryptochrome, Jetlag, and Timeless

(2009) Nicolai Peschel et al.   CURRENT BIOLOGY

A role for microRNAs in the Drosophila circadian clock

(2009) S. Kadener et al.   GENES & DEVELOPMENT

A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock

(2009) B. Maier et al.   GENES & DEVELOPMENT

An Isoform-Specific Mutant Reveals a Role of PDP1  in the Circadian Oscillator

(2009) X. Zheng et al.   JOURNAL OF NEUROSCIENCE

DOUBLETIME Plays a Noncatalytic Role To Mediate CLOCK Phosphorylation and Repress CLOCK-Dependent Transcription within the Drosophila Circadian Clock

(2009) W. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

CK2α phosphorylates BMAL1 to regulate the mammalian clock

(2009) Teruya Tamaru et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression

(2009) Christopher Vollmers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms

(2009) Y. Tsuchiya et al.   Science Signaling

The Implications of Multiple Circadian Clock Origins

(2009) Michael Rosbash   PLOS BIOLOGY

Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters

(2008) Tami A. Martino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Circadian Regulation in the Ability of Drosophila to Combat Pathogenic Infections

(2008) Jung-Eun Lee et al.   CURRENT BIOLOGY

Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen

(2008) S. Sathyanarayanan et al.   GENES & DEVELOPMENT

Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor

(2008) H. Reinke et al.   GENES & DEVELOPMENT

The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2

(2008) Kanae Ohsaki et al.   JOURNAL OF BIOCHEMISTRY

The Clockwork Orange Drosophila Protein Functions as Both an Activator and a Repressor of Clock Gene Expression

(2008) Benjamin Richier et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and A  Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2008) H. Onozuka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dual Modification of BMAL1 by SUMO2/3 and Ubiquitin Promotes Circadian Activation of the CLOCK/BMAL1 Complex

(2008) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

(2008) Qing-Jun Meng et al.   NEURON

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3 

(2008) T. Hirota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clines in clock genes: fine-tuning circadian rhythms to the environment

(2008) Charalambos P. Kyriacou et al.   TRENDS IN GENETICS

Circadian Transcription Contributes to Core Period Determination in Drosophila

(2008) Sebastian Kadener et al.   PLOS BIOLOGY