Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment

(2019) Makoto Sano et al.   Oncogenesis

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

(2019) Ivy X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases

(2019) Yuan Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis

(2019) Patrick-Simon Welz et al.   CELL

Defining the Independence of the Liver Circadian Clock

(2019) Kevin B. Koronowski et al.   CELL

The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis

(2019) Ricardo Romero-Moreno et al.   Nature Communications

Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies

(2018) Simone Mocellin et al.   BMC Medicine

PER2 regulation of mammary gland development

(2018) Cole M. McQueen et al.   DEVELOPMENT

Night shift work and breast cancer: a pooled analysis of population-based case–control studies with complete work history

(2018) Emilie Cordina-Duverger et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Sleep and circadian disruption and incident breast cancer risk: An evidence-based and theoretical review

(2018) Laura B. Samuelsson et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers

(2018) Daniel P. Hollern et al.   PLoS Genetics

Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma

(2018) Leonardo Vinícius Monteiro de Assis et al.   Frontiers in Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers

(2018) Shan Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of valid reference genes for circadian gene-expression studies in human mammary epithelial cells

(2018) Eva Hadadi et al.   CHRONOBIOLOGY INTERNATIONAL

Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues

(2018) Wenyan He et al.   IMMUNITY

The CD4/CD8 ratio of tumor-infiltrating lymphocytes at the tumor-host interface has prognostic value in triple-negative breast cancer

(2017) Kai Wang et al.   HUMAN PATHOLOGY

Cellular mechano-environment regulates the mammary circadian clock

(2017) Nan Yang et al.   Nature Communications

Remote reprogramming of hepatic circadian transcriptome by breast cancer

(2017) Hiroaki Hojo et al.   Oncotarget

mixOmics: An R package for ‘omics feature selection and multiple data integration

(2017) Florian Rohart et al.   PLoS Computational Biology

Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment

(2017) Janna Michaeli et al.   OncoImmunology

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Worse outcome in breast cancer with higher tumor-infiltrating FOXP3+ Tregs : a systematic review and meta-analysis

(2016) Jiafeng Shou et al.   BMC CANCER

Tumour-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to neoadjuvant chemotherapy of aggressive breast cancer

(2016) Y. Asano et al.   BRITISH JOURNAL OF SURGERY

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Colin W. Steele et al.   CANCER CELL

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

(2016) Selma Masri et al.   CELL

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

(2016) Thales Papagiannakopoulos et al.   Cell Metabolism

Circadian Influence on Metabolism and Inflammation in Atherosclerosis

(2016) Cameron S. McAlpine et al.   CIRCULATION RESEARCH

A matter of time: study of circadian clocks and their role in inflammation

(2016) Stuart J. Carter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues

(2016) Yen-Rei A. Yu et al.   PLoS One

Atmospheric fine particulate matter and breast cancer mortality: a population-based cohort study

(2016) Giovanna Tagliabue et al.   BMJ Open

Time-fixed feeding prevents obesity induced by chronic advances of light/dark cycles in mouse models of jet-lag/shift work

(2015) Hideaki Oike et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circadian Dysfunction Induces Leptin Resistance in Mice

(2015) Nicole M. Kettner et al.   Cell Metabolism

Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice

(2015) Kirsten C.G. Van Dycke et al.   CURRENT BIOLOGY

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Loss of circadian clock gene expression is associated with tumor progression in breast cancer

(2014) Cristina Cadenas et al.   CELL CYCLE

Mammary stem cells and the differentiation hierarchy: current status and perspectives

(2014) J. E. Visvader et al.   GENES & DEVELOPMENT

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

(2014) Julie Gibbs et al.   NATURE MEDICINE

Posttranscriptional Regulation of PER1 Underlies the Oncogenic Function of IRE 

(2013) O. Pluquet et al.   CANCER RESEARCH

Crosstalk between the circadian clock circuitry and the immune system

(2013) Nicolas Cermakian et al.   CHRONOBIOLOGY INTERNATIONAL

Impaired Cholesterol Metabolism and Enhanced Atherosclerosis in Clock Mutant Mice

(2013) Xiaoyue Pan et al.   CIRCULATION

Circadian Disruption Leads to Insulin Resistance and Obesity

(2013) Shu-qun Shi et al.   CURRENT BIOLOGY

A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating cells isolated from a Brca1-associated mouse model of breast cancer

(2013) A Vassilopoulos et al.   ONCOGENE

Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy

(2013) W. W. Hwang-Verslues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diurnal cortisol rhythm as a predictor of lung cancer survival

(2012) Sandra E. Sephton et al.   BRAIN BEHAVIOR AND IMMUNITY

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

(2012) Swarnali Acharyya et al.   CELL

Circadian Gating of Epithelial-to-Mesenchymal Transition in Breast Cancer Cells Via Melatonin-Regulation of GSK3β

(2012) Lulu Mao et al.   MOLECULAR ENDOCRINOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor

(2011) Jennifer L. Halpern et al.   CANCER LETTERS

Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action

(2011) Siddharth Sukumaran et al.   JOURNAL OF APPLIED PHYSIOLOGY

A New ImageJ Plug-in “ActogramJ” for Chronobiological Analyses

(2011) Benjamin Schmid et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer

(2011) Oshima   ONCOLOGY REPORTS

Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina

(2011) Nissa J. Mollema et al.   PLoS One

Cancer Inhibition through Circadian Reprogramming of Tumor Transcriptome with Meal Timing

(2010) X. M. Li et al.   CANCER RESEARCH

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Deletion of the PER3 Gene on Chromosome 1p36 in Recurrent ER-Positive Breast Cancer

(2010) Joan Climent et al.   JOURNAL OF CLINICAL ONCOLOGY

Reproductive biology of female Bmal1 null mice

(2010) Michael J Boden et al.   REPRODUCTION

SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor

(2009) ME Bradley et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

(2009) Hervé Acloque et al.   JOURNAL OF CLINICAL INVESTIGATION

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One