Molecular mechanisms protecting centromeres from self-sabotage and implications for cancer therapy

Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence

(2023) Xanita Saayman et al.   MOLECULAR CELL

The genetics and epigenetics of satellite centromeres

(2022) Paul B. Talbert et al.   GENOME RESEARCH

CENP-B-mediated DNA loops regulate activity and stability of human centromeres

(2022) Florian Chardon et al.   MOLECULAR CELL

Complete genomic and epigenetic maps of human centromeres

(2022) Nicolas Altemose et al.   SCIENCE

Oncogenic lncRNAs alter epigenetic memory at a fragile chromosomal site in human cancer cells

(2022) Ganesan Arunkumar et al.   Science Advances

DNMT3b protects centromere integrity by restricting R-loop-mediated DNA damage

(2022) Hsueh-Tzu Shih et al.   Cell Death & Disease

DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1

(2022) Wen-Ling Lin et al.   Cell Reports

Centromeres organize (epi)genome architecture

(2022) Paul Talbert et al.   CELL

Telomeric chromatin structure

(2022) Aghil Soman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Identifying Poly(ADP-ribose)-Binding Proteins with Photoaffinity-Based Proteomics

(2021) Morgan Dasovich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

(2021) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse mechanisms of centromere specification

(2021) Barbara G. Mellone et al.   CURRENT BIOLOGY

Activation of homologous recombination in G1 preserves centromeric integrity

(2021) Duygu Yilmaz et al.   NATURE

BRCA1 prevents R-loop-associated centromeric instability

(2021) Carine Racca et al.   Cell Death & Disease

The powerful world of antisense oligonucleotides: From bench to bedside

(2020) Anaïs M. Quemener et al.   Wiley Interdisciplinary Reviews-RNA

Guarding the Genome: CENP-A-Chromatin in Health and Cancer

(2020) Megan A. Mahlke et al.   Genes

Centromeres under Pressure: Evolutionary Innovation in Conflict with Conserved Function

(2020) Elisa Balzano et al.   Genes

R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast

(2020) Prashant K. Mishra et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

(2019) Peter Ly et al.   NATURE GENETICS

hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability

(2018) Zhengke Li et al.   EMBO JOURNAL

Simple and Complex Centromeric Satellites inDrosophilaSibling Species

(2018) Paul B. Talbert et al.   GENETICS

Non-B-Form DNA Is Enriched at Centromeres

(2018) Sivakanthan Kasinathan et al.   MOLECULAR BIOLOGY AND EVOLUTION

Simple and Complex Centromeric Satellites inDrosophilaSibling Species

(2018) Paul B. Talbert et al.   GENETICS

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

(2018) Samuel F. Bakhoum et al.   CELL

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

Repetitive Fragile Sites: Centromere Satellite DNA As a Source of Genome Instability in Human Diseases

(2018) Elizabeth M. Black et al.   Genes

Centromere and Pericentromere Transcription: Roles and Regulation … in Sickness and in Health

(2018) Ksenia Smurova et al.   Frontiers in Genetics

Essential role for centromeric factors following p53 loss and oncogenic transformation

(2017) Dan Filipescu et al.   GENES & DEVELOPMENT

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis

(2017) Peter Ly et al.   TRENDS IN CELL BIOLOGY

Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

(2017) Xiaowen Zhang et al.   Nature Communications

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

(2016) Katerina Tsouroula et al.   MOLECULAR CELL

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

(2016) Weiguo Zhang et al.   Nature Communications

Replication, checkpoint suppression and structure of centromeric DNA

(2016) Francesco Romeo et al.   Nucleus

Replication, checkpoint suppression and structure of centromeric DNA

(2016) Francesco Romeo et al.   Nucleus

Antimitotic drugs in the treatment of cancer

(2015) Rustelle Janse van Vuuren et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Centromeric Alpha-Satellite DNA Adopts Dimeric i-Motif Structures Capped by AT Hoogsteen Base Pairs

(2015) Miguel Garavís et al.   CHEMISTRY-A EUROPEAN JOURNAL

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

(2015) Daniele Fachinetti et al.   DEVELOPMENTAL CELL

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts

(2015) Dhvani Parikh et al.   Nature Communications

The structure of an endogenous Drosophila centromere reveals the prevalence of tandemly repeated sequences able to form i-motifs

(2015) Miguel Garavís et al.   Scientific Reports

Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division

(2014) Silvana Rošić et al.   JOURNAL OF CELL BIOLOGY

Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome

(2014) Indri Erliandri et al.   NUCLEIC ACIDS RESEARCH

A long non-coding RNA is required for targeting centromeric protein A to the human centromere

(2014) Delphine Quénet et al.   eLife

The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development

(2012) Maikel Castellano-Pozo et al.   PLoS One

The impact of heterochromatin on DSB repair

(2009) Aaron A. Goodarzi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

(2009) Suhasni Gopalakrishnan et al.   HUMAN MOLECULAR GENETICS

Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase

(2009) Federica Ferri et al.   NUCLEIC ACIDS RESEARCH

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

Hairpin structures formed by alpha satellite DNA of human centromeres are cleaved by human topoisomerase II 

(2008) A. T. Jonstrup et al.   NUCLEIC ACIDS RESEARCH