Diverse mechanisms of centromere specification

Cryo‐EM structure of the CENP‐A nucleosome in complex with phosphorylated CENP‐C

(2021) Mariko Ariyoshi et al.   EMBO JOURNAL

Induction of spontaneous human neocentromere formation and long-term maturation

(2021) Marina Murillo-Pineda et al.   JOURNAL OF CELL BIOLOGY

Emerging roles of centromeric RNAs in centromere formation and function

(2021) Qian Liu et al.   Genes & Genomics

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

(2021) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Centromeric transcription maintains centromeric cohesion in human cells

(2021) Yujue Chen et al.   JOURNAL OF CELL BIOLOGY

Comparative analyses of gibbon centromeres reveal dynamic genus specific shifts in repeat composition

(2021) Gabrielle A Hartley et al.   MOLECULAR BIOLOGY AND EVOLUTION

The structure, function and evolution of a complete human chromosome 8

(2021) Glennis A. Logsdon et al.   NATURE

Kinetoplastid kinetochore proteins KKT2 and KKT3 have unique centromere localization domains

(2021) Gabriele Marcianò et al.   JOURNAL OF CELL BIOLOGY

Dynamics of kinetochore structure and its regulations during mitotic progression

(2020) Masatoshi Hara et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CenH3-Independent Kinetochore Assembly in Lepidoptera Requires CCAN, Including CENP-T

(2020) Nuria Cortes-Silva et al.   CURRENT BIOLOGY

Targeted De Novo Centromere Formation in Drosophila Reveals Plasticity and Maintenance Potential of CENP-A Chromatin

(2020) Jason Palladino et al.   DEVELOPMENTAL CELL

Structural basis for centromere maintenance by Drosophila CENP ‐A chaperone CAL 1

(2020) Bethan Medina‐Pritchard et al.   EMBO JOURNAL

Genetics, epigenetics and back again: Lessons learned from neocentromeres

(2020) Marina Murillo-Pineda et al.   EXPERIMENTAL CELL RESEARCH

Artificial generation of centromeres and kinetochores to understand their structure and function

(2020) Tetsuya Hori et al.   EXPERIMENTAL CELL RESEARCH

What makes a centromere?

(2020) Paul B. Talbert et al.   EXPERIMENTAL CELL RESEARCH

Genomic and functional variation of human centromeres

(2020) Lori L. Sullivan et al.   EXPERIMENTAL CELL RESEARCH

Human artificial chromosome: Chromatin assembly mechanisms and CENP-B

(2020) Jun-ichirou Ohzeki et al.   EXPERIMENTAL CELL RESEARCH

Cohesin Removal Reprograms Gene Expression upon Mitotic Entry

(2020) Carlos Perea-Resa et al.   MOLECULAR CELL

From evolution to function: Two sides of the same CENP-B coin?

(2020) Riccardo Gamba et al.   EXPERIMENTAL CELL RESEARCH

Centromeric RNA and Its Function at and Beyond Centromeric Chromatin

(2020) Samuel Corless et al.   JOURNAL OF MOLECULAR BIOLOGY

CENP-A nucleosome—a chromatin-embedded pedestal for the centromere: lessons learned from structural biology

(2020) Ahmad Ali-Ahmad et al.   Essays in Biochemistry

CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly

(2020) Koichiro Otake et al.   JOURNAL OF CELL SCIENCE

Telomere-to-telomere assembly of a complete human X chromosome

(2020) Karen H. Miga et al.   NATURE

Spt6 is a maintenance factor for centromeric CENP-A

(2020) Georg O. M. Bobkov et al.   Nature Communications

Centromeres under Pressure: Evolutionary Innovation in Conflict with Conserved Function

(2020) Elisa Balzano et al.   Genes

A genetic memory initiates the epigenetic loop necessary to preserve centromere position

(2020) Sebastian Hoffmann et al.   EMBO JOURNAL

Stable inheritance of CENP-A chromatin: Inner strength versus dynamic control

(2020) Sreyoshi Mitra et al.   JOURNAL OF CELL BIOLOGY

The elusive structure of centro-chromatin: molecular order or dynamic heterogenetity?

(2020) Harsh Nagpal et al.   JOURNAL OF MOLECULAR BIOLOGY

Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoids Active Chromatin

(2020) Aruni P. Senaratne et al.   CURRENT BIOLOGY

The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism

(2019) Yasuhiro Arimura et al.   Nature Communications

Islands of retroelements are major components of Drosophila centromeres

(2019) Ching-Ho Chang et al.   PLOS BIOLOGY

Centromeric Satellite DNAs: Hidden Sequence Variation in the Human Population

(2019) Miga   Genes

Human Artificial Chromosomes that Bypass Centromeric DNA

(2019) Glennis A. Logsdon et al.   CELL

De novo formation and epigenetic maintenance of centromere chromatin

(2019) Junichirou Ohzeki et al.   CURRENT OPINION IN CELL BIOLOGY

DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres

(2019) Yael Nechemia-Arbely et al.   NATURE CELL BIOLOGY

Interspecies conservation of organisation and function between nonhomologous regional centromeres

(2019) Pin Tong et al.   Nature Communications

Keeping the Centromere under Control: A Promising Role for DNA Methylation

(2019) Scelfo et al.   Cells

Early Diverging Fungus Mucor circinelloides Lacks Centromeric Histone CENP-A and Displays a Mosaic of Point and Regional Centromeres

(2019) María Isabel Navarro-Mendoza et al.   CURRENT BIOLOGY

Human chromosome‐specific aneuploidy is influenced by DNA ‐dependent centromeric features

(2019) Marie Dumont et al.   EMBO JOURNAL

CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization

(2019) Reito Watanabe et al.   JOURNAL OF CELL BIOLOGY

Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners

(2019) Daniël P. Melters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1

(2019) Leonid Andronov et al.   Nature Communications

Reconstituting Drosophila Centromere Identity in Human Cells

(2019) Virginie Roure et al.   Cell Reports

Alpha satellite DNA biology: finding function in the recesses of the genome

(2018) Shannon M. McNulty et al.   CHROMOSOME RESEARCH

Transposable elements: genome innovation, chromosome diversity, and centromere conflict

(2018) Savannah J. Klein et al.   CHROMOSOME RESEARCH

Posttranslational mechanisms controlling centromere function and assembly

(2018) Shashank Srivastava et al.   CURRENT OPINION IN CELL BIOLOGY

Centromeric retrotransposons and centromere function

(2018) Gernot G Presting   CURRENT OPINION IN GENETICS & DEVELOPMENT

Birth, evolution, and transmission of satellite-free mammalian centromeric domains

(2018) Solomon G. Nergadze et al.   GENOME RESEARCH

Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation

(2018) Georg O.M. Bobkov et al.   JOURNAL OF CELL BIOLOGY

Linear assembly of a human centromere on the Y chromosome

(2018) Miten Jain et al.   NATURE BIOTECHNOLOGY

Adaptation and conservation insights from the koala genome

(2018) Rebecca N. Johnson et al.   NATURE GENETICS

Transcribing Centromeres: Noncoding RNAs and Kinetochore Assembly

(2018) Paul B. Talbert et al.   TRENDS IN GENETICS

The kinetoplastid kinetochore protein KKT4 is an unconventional microtubule tip–coupling protein

(2018) Aida Llauró et al.   JOURNAL OF CELL BIOLOGY

Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle

(2018) Manu Shukla et al.   CURRENT BIOLOGY

Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP

(2018) Ewelina Zasadzińska et al.   DEVELOPMENTAL CELL

Holliday junction recognition protein interacts with and specifies the centromeric assembly of CENP-T

(2018) Mingrui Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points

(2017) Yael Nechemia-Arbely et al.   JOURNAL OF CELL BIOLOGY

A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly

(2017) Ana Stankovic et al.   MOLECULAR CELL

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Centromeres Drive a Hard Bargain

(2017) Leah F. Rosin et al.   TRENDS IN GENETICS

CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx

(2017) Viacheslav M. Morozov et al.   Epigenetics & Chromatin

Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition

(2017) Lucie Y. Guo et al.   Nature Communications

Decoding the centromeric nucleosome through CENP-N

(2017) Satyakrishna Pentakota et al.   eLife

CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

(2017) Dongqing Pan et al.   eLife

The unconventional kinetoplastid kinetochore: from discovery toward functional understanding

(2016) Bungo Akiyoshi   BIOCHEMICAL SOCIETY TRANSACTIONS

Transcription brings the complex(ity) to the centromere

(2016) Andrew W. Grenfell et al.   CELL CYCLE

KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation

(2016) Jun-ichirou Ohzeki et al.   DEVELOPMENTAL CELL

Licensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer

(2016) Isaac K. Nardi et al.   MOLECULAR CELL

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

Inbreeding drives maize centromere evolution

(2016) Kevin L. Schneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inheritance of the CENP-A chromatin domain is spatially and temporally constrained at human centromeres

(2016) Justyne E. Ross et al.   Epigenetics & Chromatin

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

(2016) Oscar Molina et al.   Nature Communications

CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly

(2016) Sebastian Hoffmann et al.   Cell Reports

Differential Binding Partners of the Mis18α/β YIPPEE Domains Regulate Mis18 Complex Recruitment to Centromeres

(2016) Madison E. Stellfox et al.   Cell Reports

CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions

(2016) Yohei Niikura et al.   Cell Reports

Centromeric Transcription Regulates Aurora-B Localization and Activation

(2016) Michael D. Blower   Cell Reports

High Quality Maize Centromere 10 Sequence Reveals Evidence of Frequent Recombination Events

(2016) Thomas K. Wolfgruber et al.   Frontiers in Plant Science

Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription

(2015) Chin-Chi Chen et al.   DEVELOPMENTAL CELL

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

(2015) Daniele Fachinetti et al.   DEVELOPMENTAL CELL

CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores

(2015) Kerstin Klare et al.   JOURNAL OF CELL BIOLOGY

Identification of the Post-translational Modifications Present in Centromeric Chromatin

(2015) Aaron O. Bailey et al.   MOLECULAR & CELLULAR PROTEOMICS

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stable complex formation of CENP-B with the CENP-A nucleosome

(2015) Risa Fujita et al.   NUCLEIC ACIDS RESEARCH

CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

(2015) S. J. Falk et al.   SCIENCE

The structure of an endogenous Drosophila centromere reveals the prevalence of tandemly repeated sequences able to form i-motifs

(2015) Miguel Garavís et al.   Scientific Reports

HJURP Involvement in De Novo CenH3CENP-A and CENP-C Recruitment

(2015) Hiroaki Tachiwana et al.   Cell Reports

Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin

(2015) Sandra Catania et al.   PLoS Genetics

Centromeric Heterochromatin: The Primordial Segregation Machine

(2014) Kerry S. Bloom   Annual Review of Genetics

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

CAL1 is theDrosophilaCENP-A assembly factor

(2014) Chin-Chi Chen et al.   JOURNAL OF CELL BIOLOGY

Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division

(2014) Silvana Rošić et al.   JOURNAL OF CELL BIOLOGY

A Regulatory Effect of INMAP on Centromere Proteins: Antisense INMAP Induces CENP-B Variation and Centromeric Halo

(2014) Tan Tan et al.   PLoS One

The Centromere: Epigenetic Control of Chromosome Segregation during Mitosis

(2014) Frederick G. Westhorpe et al.   Cold Spring Harbor Perspectives in Biology

Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects

(2014) Ines A Drinnenberg et al.   eLife

The quantitative architecture of centromeric chromatin

(2014) Dani L Bodor et al.   eLife

βTrCP-mediated ubiquitylation regulates protein stability of Mis18β in a cell cycle-dependent manner

(2013) Ik Soo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Three Potato Centromeres Are Associated with Distinct Haplotypes with or Without Megabase-Sized Satellite Repeat Arrays

(2013) L. Wang et al.   GENETICS

The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly

(2013) Tetsuya Hori et al.   JOURNAL OF CELL BIOLOGY

Identification of Novel α-N-Methylation of CENP-B That Regulates Its Binding to the Centromeric DNA

(2013) Xiaoxia Dai et al.   JOURNAL OF PROTEOME RESEARCH

The octamer is the major form of CENP-A nucleosomes at human centromeres

(2013) Dan Hasson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nap1 regulates proper CENP-B binding to nucleosomes

(2013) Hiroaki Tachiwana et al.   NUCLEIC ACIDS RESEARCH

Chromatin and DNA Replication

(2013) D. M. MacAlpine et al.   Cold Spring Harbor Perspectives in Biology

Centromere Remodeling in Hoolock leuconedys (Hylobatidae) by a New Transposable Element Unique to the Gibbons

(2012) Lucia Carbone et al.   Genome Biology and Evolution

An inverse relationship to germline transcription defines centromeric chromatin in C. elegans

(2012) Reto Gassmann et al.   NATURE

Transcription in the maintenance of centromere chromatin identity

(2012) F. L. Chan et al.   NUCLEIC ACIDS RESEARCH

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative single-molecule microscopy reveals that CENP-ACnp1 deposition occurs during G2 in fission yeast

(2012) D. Lando et al.   Open Biology

CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin

(2012) Silvia Dambacher et al.   Nucleus

Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP

(2011) H. Hu et al.   GENES & DEVELOPMENT

Identification of Noncoding Transcripts from within CENP-A Chromatin at Fission Yeast Centromeres

(2011) Eun Shik Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly

(2011) Ben Moree et al.   JOURNAL OF CELL BIOLOGY

HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

(2011) Meghan C. Barnhart et al.   JOURNAL OF CELL BIOLOGY

Assembly of Drosophila Centromeric Chromatin Proteins during Mitosis

(2011) Barbara G. Mellone et al.   PLoS Genetics

H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G1phase

(2011) Elaine M. Dunleavy et al.   Nucleus

Zygotic Resetting of the HISTONE 3 Variant Repertoire Participates in Epigenetic Reprogramming in Arabidopsis

(2010) Mathieu Ingouff et al.   CURRENT BIOLOGY

Vertebrate kinetochore protein architecture: protein copy number

(2010) Katherine Johnston et al.   JOURNAL OF CELL BIOLOGY

Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors

(2010) Emily A. Bassett et al.   JOURNAL OF CELL BIOLOGY

Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1

(2010) R. B. Schittenhelm et al.   JOURNAL OF CELL SCIENCE

A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A

(2010) Anaïck Lagana et al.   NATURE CELL BIOLOGY

A super-resolution map of the vertebrate kinetochore

(2010) S. A. Ribeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncoupling of Satellite DNA and Centromeric Function in the Genus Equus

(2010) Francesca M. Piras et al.   PLoS Genetics

Distinct retroelement classes define evolutionary breakpoints demarcating sites of evolutionary novelty

(2009) Mark S Longo et al.   BMC GENOMICS

The life and miracles of kinetochores

(2009) Stefano Santaguida et al.   EMBO JOURNAL

LINE Retrotransposon RNA Is an Essential Structural and Functional Epigenetic Component of a Core Neocentromeric Chromatin

(2009) Anderly C. Chueh et al.   PLoS Genetics

Maize Centromere Structure and Evolution: Sequence Analysis of Centromeres 2 and 5 Reveals Dynamic Loci Shaped Primarily by Retrotransposons

(2009) Thomas K. Wolfgruber et al.   PLoS Genetics

Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

(2008) Owen J. Marshall et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin

(2008) Owen J. Marshall et al.   JOURNAL OF CELL BIOLOGY

The role of alphoid higher order repeats (HORs) in the centromere folding

(2008) Marija Rosandić et al.   JOURNAL OF THEORETICAL BIOLOGY