Activation of homologous recombination in G1 preserves centromeric integrity

RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination

(2021) Sijie Liu et al.   CELL

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

(2021) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA transcripts stimulate homologous recombination by forming DR-loops

(2021) Jian Ouyang et al.   NATURE

R-loops as Janus-faced modulators of DNA repair

(2021) Aline Marnef et al.   NATURE CELL BIOLOGY

CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

(2021) Daniel Jeffery et al.   Communications Biology

DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

(2021) Pedro Ortega et al.   eLife

On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability

(2020) Alexandra N. Khristich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-coding RNAs at the eukaryotic rDNA locus: RNA-DNA hybrids and beyond

(2020) Olga Vydzhak et al.   JOURNAL OF MOLECULAR BIOLOGY

Nucleolar RNA polymerase II drives ribosome biogenesis

(2020) Karan J. Abraham et al.   NATURE

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

(2020) Marianna Feretzaki et al.   NATURE

R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast

(2020) Prashant K. Mishra et al.   MOLECULAR BIOLOGY OF THE CELL

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

(2017) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

(2017) Pedro A Mateos-Gomez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CENP-A chromatin disassembly in stressed and senescent murine cells

(2017) Sabrine Hédouin et al.   Scientific Reports

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(2016) Corina Ohle et al.   CELL

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

(2016) Katerina Tsouroula et al.   MOLECULAR CELL

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

(2016) Oscar Molina et al.   Nature Communications

CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere

(2015) Yohei Niikura et al.   DEVELOPMENTAL CELL

A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage

(2015) Marjolein van Sluis et al.   GENES & DEVELOPMENT

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

H3K4me2 reliably defines transcription factor binding regions in different cells

(2014) Ying Wang et al.   GENOMICS

Mislocalization of the Centromeric Histone Variant CenH3/CENP-A in Human Cells Depends on the Chaperone DAXX

(2014) Nicolas Lacoste et al.   MOLECULAR CELL

The Kinetochore

(2014) I. M. Cheeseman   Cold Spring Harbor Perspectives in Biology

A long non-coding RNA is required for targeting centromeric protein A to the human centromere

(2014) Delphine Quénet et al.   eLife

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

(2013) Maikel Castellano-Pozo et al.   MOLECULAR CELL

Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas

(2011) C. Martinez-A et al.   CARCINOGENESIS

HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

(2011) Meghan C. Barnhart et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A role for recombination in centromere function

(2010) Ramsay J. McFarlane et al.   TRENDS IN GENETICS

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

Double-strand DNA breaks recruit the centromeric histone CENP-A

(2009) S. G. Zeitlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe

(2008) Ken-ichi Nakamura et al.   EMBO JOURNAL