Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

RANKL/RANK control Brca1 mutation-driven mammary tumors

(2016) Verena Sigl et al.   CELL RESEARCH

Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage

(2016) Andrea Sau et al.   Cell Stem Cell

Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals

(2016) Lionel A. Sanz et al.   MOLECULAR CELL

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

(2016) Emma Nolan et al.   NATURE MEDICINE

Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development

(2016) Sreejith J. Nair et al.   Nature Communications

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

(2016) Caroline Townsend Stork et al.   eLife

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

Epigenetic and transcriptional determinants of the human breast

(2015) Philippe Gascard et al.   Nature Communications

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence

(2015) Maja Sedic et al.   Nature Communications

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation

(2014) A. Gardini et al.   EMBO JOURNAL

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

(2014) Sarah J. Hill et al.   GENES & DEVELOPMENT

Mammary stem cells and the differentiation hierarchy: current status and perspectives

(2014) J. E. Visvader et al.   GENES & DEVELOPMENT

Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein (snRNP) Activates Hexamethylene Bisacetamide-inducible Protein (HEXIM1) Transcription

(2014) Pingyang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

(2014) Nicholas A. Willis et al.   NATURE

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

Tissue-specific tumor suppression by BRCA1

(2014) E. Y.- H. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

(2014) A. R. Venkitaraman   SCIENCE

Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes

(2014) Bernd Stadelmayer et al.   Nature Communications

BRCA1 haploinsufficiency for replication stress suppression in primary cells

(2014) Shailja Pathania et al.   Nature Communications

Control of Transcriptional Elongation

(2013) Hojoong Kwak et al.   Annual Review of Genetics

Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing

(2013) Milan Radovich et al.   BREAST CANCER RESEARCH AND TREATMENT

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Mechanisms of BRCA1 Tumor Suppression: Figure 1.

(2012) Daniel P. Silver et al.   Cancer Discovery

Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

(2011) Theresa A. Proia et al.   Cell Stem Cell

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis

(2011) Julia J. Gorski et al.   NUCLEIC ACIDS RESEARCH

BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers

(2011) D Tkocz et al.   ONCOGENE

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

(2010) Gemma Molyneux et al.   Cell Stem Cell

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

(2009) Elgene Lim et al.   NATURE MEDICINE

Mouse Cofactor of BRCA1 (Cobra1) Is Required for Early Embryogenesis

(2009) Asma Amleh et al.   PLoS One

BioVenn – a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams

(2008) Tim Hulsen et al.   BMC GENOMICS

A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability

(2008) Peter Eirew et al.   NATURE MEDICINE

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY