The molecular basis for centromere identity and function

The CENP-A N-Tail Confers Epigenetic Stability to Centromeres via the CENP-T Branch of the CCAN in Fission Yeast

(2015) H. Diego Folco et al.   CURRENT BIOLOGY

Distinct Organization and Regulation of the Outer Kinetochore KMN Network Downstream of CENP-C and CENP-T

(2015) Florencia Rago et al.   CURRENT BIOLOGY

CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere

(2015) Yohei Niikura et al.   DEVELOPMENTAL CELL

Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription

(2015) Chin-Chi Chen et al.   DEVELOPMENTAL CELL

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

(2015) Daniele Fachinetti et al.   DEVELOPMENTAL CELL

Dynamic Phosphorylation of CENP-A at Ser68 Orchestrates Its Cell-Cycle-Dependent Deposition at Centromeres

(2015) Zhouliang Yu et al.   DEVELOPMENTAL CELL

CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores

(2015) Kerstin Klare et al.   JOURNAL OF CELL BIOLOGY

A cell-free CENP-A assembly system defines the chromatin requirements for centromere maintenance

(2015) Frederick G. Westhorpe et al.   JOURNAL OF CELL BIOLOGY

Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores

(2015) Soonjoung Kim et al.   JOURNAL OF CELL BIOLOGY

Both tails and the centromere targeting domain of CENP-A are required for centromere establishment

(2015) Glennis A. Logsdon et al.   JOURNAL OF CELL BIOLOGY

Dynamic changes in CCAN organization through CENP-C during cell-cycle progression

(2015) Harsh Nagpal et al.   MOLECULAR BIOLOGY OF THE CELL

HJURP is involved in the expansion of centromeric chromatin

(2015) Marinela Perpelescu et al.   MOLECULAR BIOLOGY OF THE CELL

Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation

(2015) Hong Liu et al.   MOLECULAR CELL

Stable complex formation of CENP-B with the CENP-A nucleosome

(2015) Risa Fujita et al.   NUCLEIC ACIDS RESEARCH

CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere

(2015) S. J. Falk et al.   SCIENCE

HJURP Involvement in De Novo CenH3CENP-A and CENP-C Recruitment

(2015) Hiroaki Tachiwana et al.   Cell Reports

CENP-A Arrays Are More Condensed than Canonical Arrays at Low Ionic Strength

(2014) Christian P. Geiss et al.   BIOPHYSICAL JOURNAL

Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres

(2014) Kara L. McKinley et al.   CELL

Discovery of Unconventional Kinetochores in Kinetoplastids

(2014) Bungo Akiyoshi et al.   CELL

Loading of the centromeric histone H3 variant during meiosis–how does it differ from mitosis?

(2014) Veit Schubert et al.   CHROMOSOMA

The CENP-O complex requirement varies among different cell types

(2014) Naoko Kagawa et al.   CHROMOSOME RESEARCH

The Architecture of CCAN Proteins Creates a Structural Integrity to Resist Spindle Forces and Achieve Proper Intrakinetochore Stretch

(2014) Aussie Suzuki et al.   DEVELOPMENTAL CELL

Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly

(2014) Tetsuya Hori et al.   DEVELOPMENTAL CELL

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A

(2014) Gary M.R. Deyter et al.   GENES & DEVELOPMENT

Mitotic Regulator Mis18β Interacts with and Specifies the Centromeric Assembly of Molecular Chaperone Holliday Junction Recognition Protein (HJURP)

(2014) Jianyu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CAL1 is theDrosophilaCENP-A assembly factor

(2014) Chin-Chi Chen et al.   JOURNAL OF CELL BIOLOGY

A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A

(2014) Peter Hornung et al.   JOURNAL OF CELL BIOLOGY

Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division

(2014) Silvana Rošić et al.   JOURNAL OF CELL BIOLOGY

Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways

(2014) J. Bancroft et al.   JOURNAL OF CELL SCIENCE

The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin

(2014) Teppei Kitagawa et al.   Nature Communications

Phosphorylation and DNA Binding of HJURP Determine Its Centromeric Recruitment and Function in CenH3CENP-A Loading

(2014) Sebastian Müller et al.   Cell Reports

Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects

(2014) Ines A Drinnenberg et al.   eLife

The quantitative architecture of centromeric chromatin

(2014) Dani L Bodor et al.   eLife

The pseudo GTPase CENP-M drives human kinetochore assembly

(2014) Federica Basilico et al.   eLife

A long non-coding RNA is required for targeting centromeric protein A to the human centromere

(2014) Delphine Quénet et al.   eLife

The Past, Present, and Future of Human Centromere Genomics

(2014) Megan Aldrup-MacDonald et al.   Genes

Chromosome Engineering Allows the Efficient Isolation of Vertebrate Neocentromeres

(2013) Wei-Hao Shang et al.   DEVELOPMENTAL CELL

Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome deposition

(2013) Ewelina Zasadzińska et al.   EMBO JOURNAL

A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

(2013) Francesca Malvezzi et al.   EMBO JOURNAL

CENP-T provides a structural platform for outer kinetochore assembly

(2013) Tatsuya Nishino et al.   EMBO JOURNAL

The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly

(2013) Tetsuya Hori et al.   JOURNAL OF CELL BIOLOGY

CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state

(2013) Karen E. Gascoigne et al.   JOURNAL OF CELL BIOLOGY

Assembly in G1 phase and long-term stability are unique intrinsic features of CENP-A nucleosomes

(2013) Dani L. Bodor et al.   MOLECULAR BIOLOGY OF THE CELL

A two-step mechanism for epigenetic specification of centromere identity and function

(2013) Daniele Fachinetti et al.   NATURE CELL BIOLOGY

Solo or doppio: how many CENP-As make a centromeric nucleosome?

(2013) Elaine M Dunleavy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The octamer is the major form of CENP-A nucleosomes at human centromeres

(2013) Dan Hasson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The centromeric nucleosome-like CENP–T–W–S–X complex induces positive supercoils into DNA

(2013) Kozo Takeuchi et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function

(2013) D. Goutte-Gattat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranslational modification of CENP-A influences the conformation of centromeric chromatin

(2013) A. O. Bailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C

(2013) H. Kato et al.   SCIENCE

Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans

(2013) Stefan Westermann et al.   TRENDS IN CELL BIOLOGY

An Iml3-Chl4 Heterodimer Links the Core Centromere to Factors Required for Accurate Chromosome Segregation

(2013) Stephen M. Hinshaw et al.   Cell Reports

CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold

(2012) Tatsuya Nishino et al.   CELL

Cell-Cycle-Dependent Structural Transitions in the Human CENP-A Nucleosome In Vivo

(2012) Minh Bui et al.   CELL

The evolutionary life cycle of the resilient centromere

(2012) Paul Kalitsis et al.   CHROMOSOMA

Epigenetic Inactivation and Subsequent Heterochromatinization of a Centromere Stabilize Dicentric Chromosomes

(2012) Hiroshi Sato et al.   CURRENT BIOLOGY

HJURP Uses Distinct CENP-A Surfaces to Recognize and to Stabilize CENP-A/Histone H4 for Centromere Assembly

(2012) Emily A. Bassett et al.   DEVELOPMENTAL CELL

Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

(2012) Jun-ichirou Ohzeki et al.   EMBO JOURNAL

Replicating centromeric chromatin: Spatial and temporal control of CENP-A assembly

(2012) Yael Nechemia-Arbely et al.   EXPERIMENTAL CELL RESEARCH

Roles of Mis18α in Epigenetic Regulation of Centromeric Chromatin and CENP-A Loading

(2012) Ik Soo Kim et al.   MOLECULAR CELL

An inverse relationship to germline transcription defines centromeric chromatin in C. elegans

(2012) Reto Gassmann et al.   NATURE

CENP-T proteins are conserved centromere receptors of the Ndc80 complex

(2012) Alexander Schleiffer et al.   NATURE CELL BIOLOGY

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational Propagation and Quantitative Maintenance of Paternal Centromeres Depends on Cid/Cenp-A Presence in Drosophila Sperm

(2012) Nitika Raychaudhuri et al.   PLOS BIOLOGY

The Cell Cycle Timing of Centromeric Chromatin Assembly in Drosophila Meiosis Is Distinct from Mitosis Yet Requires CAL1 and CENP-C

(2012) Elaine M. Dunleavy et al.   PLOS BIOLOGY

CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin

(2012) Silvia Dambacher et al.   Nucleus

Induced Ectopic Kinetochore Assembly Bypasses the Requirement for CENP-A Nucleosomes

(2011) Karen E. Gascoigne et al.   CELL

Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells

(2011) Lori L. Sullivan et al.   CHROMOSOME RESEARCH

Direct Binding of Cenp-C to the Mis12 Complex Joins the Inner and Outer Kinetochore

(2011) Emanuela Screpanti et al.   CURRENT BIOLOGY

CENP-C Is a Structural Platform for Kinetochore Assembly

(2011) Marcin R. Przewloka et al.   CURRENT BIOLOGY

Cdk Activity Couples Epigenetic Centromere Inheritance to Cell Cycle Progression

(2011) Mariana C.C. Silva et al.   DEVELOPMENTAL CELL

Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP

(2011) H. Hu et al.   GENES & DEVELOPMENT

Centromere repositioning in mammals

(2011) M Rocchi et al.   HEREDITY

Identification of Noncoding Transcripts from within CENP-A Chromatin at Fission Yeast Centromeres

(2011) Eun Shik Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly

(2011) Ben Moree et al.   JOURNAL OF CELL BIOLOGY

HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore

(2011) Meghan C. Barnhart et al.   JOURNAL OF CELL BIOLOGY

Comparative and demographic analysis of orang-utan genomes

(2011) Devin P. Locke et al.   NATURE

Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3

(2011) Zheng Zhou et al.   NATURE

In vitro centromere and kinetochore assembly on defined chromatin templates

(2011) Annika Guse et al.   NATURE

Crystal structure of the human centromeric nucleosome containing CENP-A

(2011) Hiroaki Tachiwana et al.   NATURE

Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini

(2011) T. Panchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila CENH3 Is Sufficient for Centromere Formation

(2011) M. J. Mendiburo et al.   SCIENCE

Assembly of Drosophila Centromeric Chromatin Proteins during Mitosis

(2011) Barbara G. Mellone et al.   PLoS Genetics

H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G1phase

(2011) Elaine M. Dunleavy et al.   Nucleus

Neocentrics and Holokinetics (Holocentrics): Chromosomes out of the Centromeric Rules

(2010) M. Guerra et al.   CYTOGENETIC AND GENOME RESEARCH

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequences

(2010) W.-H. Shang et al.   GENOME RESEARCH

GENETICS, ORIGIN AND EVOLUTION OF KINETOCHORES

(2010) A. LIMA-DE-FARIA   HEREDITAS

Dual recognition of CENP-A nucleosomes is required for centromere assembly

(2010) Christopher W. Carroll et al.   JOURNAL OF CELL BIOLOGY

Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1

(2010) R. B. Schittenhelm et al.   JOURNAL OF CELL SCIENCE

The structure of (CENP-A–H4)2 reveals physical features that mark centromeres

(2010) Nikolina Sekulic et al.   NATURE

Molecular control of kinetochore-microtubule dynamics and chromosome oscillations

(2010) Ana C. Amaro et al.   NATURE CELL BIOLOGY

A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A

(2010) Anaïck Lagana et al.   NATURE CELL BIOLOGY

HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres

(2010) M. Shuaib et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A super-resolution map of the vertebrate kinetochore

(2010) S. A. Ribeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A paucity of heterochromatin at functional human neocentromeres

(2010) Alicia Alonso et al.   Epigenetics & Chromatin

Uncoupling of Satellite DNA and Centromeric Function in the Genus Equus

(2010) Francesca M. Piras et al.   PLoS Genetics

Common Ancestry of the CENP-A Chaperones Scm3 and HJURP

(2009) Luis Sanchez-Pulido et al.   CELL

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

Isodicentric Y Chromosomes and Sex Disorders as Byproducts of Homologous Recombination that Maintains Palindromes

(2009) Julian Lange et al.   CELL

Major Evolutionary Transitions in Centromere Complexity

(2009) Harmit S. Malik et al.   CELL

The CENP-S complex is essential for the stable assembly of outer kinetochore structure

(2009) Miho Amano et al.   JOURNAL OF CELL BIOLOGY

Active establishment of centromeric CENP-A chromatin by RSF complex

(2009) Marinela Perpelescu et al.   JOURNAL OF CELL BIOLOGY

Dissection of CENP-C–directed Centromere and Kinetochore Assembly

(2009) Kirstin J. Milks et al.   MOLECULAR BIOLOGY OF THE CELL

CENP-H–containing Complex Facilitates Centromere Deposition of CENP-A in Cooperation with FACT and CHD1

(2009) Masahiro Okada et al.   MOLECULAR BIOLOGY OF THE CELL

Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N

(2009) Christopher W. Carroll et al.   NATURE CELL BIOLOGY

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neocentromeres Form Efficiently at Multiple Possible Loci in Candida albicans

(2009) Carrie Ketel et al.   PLoS Genetics

Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution

(2008) Owen J. Marshall et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore

(2008) Tetsuya Hori et al.   CELL

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

Genome-wide analysis reveals a cell cycle–dependent mechanism controlling centromere propagation

(2008) Sylvia Erhardt et al.   JOURNAL OF CELL BIOLOGY

Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres

(2008) H. D. Folco et al.   SCIENCE

Heterochromatin Integrity Affects Chromosome Reorganization After Centromere Dysfunction

(2008) K. Ishii et al.   SCIENCE

CENP-O Class Proteins Form a Stable Complex and Are Required for Proper Kinetochore Function

(2007) Tetsuya Hori et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular architecture of the kinetochore–microtubule interface

(2007) Iain M. Cheeseman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY