Repetitive Fragile Sites: Centromere Satellite DNA As a Source of Genome Instability in Human Diseases

Posttranslational modifications of CENP-A: marks of distinction

(2018) Shashank Srivastava et al.   CHROMOSOMA

Alpha satellite DNA biology: finding function in the recesses of the genome

(2018) Shannon M. McNulty et al.   CHROMOSOME RESEARCH

Transposable elements: genome innovation, chromosome diversity, and centromere conflict

(2018) Savannah J. Klein et al.   CHROMOSOME RESEARCH

hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability

(2018) Zhengke Li et al.   EMBO JOURNAL

Loss of Elongation-Like Factor 1 Spontaneously Induces Diverse, RNase H-Related Suppressor Mutations inSchizosaccharomyces pombe

(2018) Bahjat F. Marayati et al.   GENETICS

Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state

(2018) Guillaume Velasco et al.   HUMAN MOLECULAR GENETICS

Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation

(2018) Georg O.M. Bobkov et al.   JOURNAL OF CELL BIOLOGY

Non-B-Form DNA Is Enriched at Centromeres

(2018) Sivakanthan Kasinathan et al.   MOLECULAR BIOLOGY AND EVOLUTION

Nanopore sequencing and assembly of a human genome with ultra-long reads

(2018) Miten Jain et al.   NATURE BIOTECHNOLOGY

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

(2018) Christopher Jenness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How RNA transcripts coordinate DNA recombination and repair

(2018) Shane McDevitt et al.   Nature Communications

Loss of Elongation-Like Factor 1 Spontaneously Induces Diverse, RNase H-Related Suppressor Mutations inSchizosaccharomyces pombe

(2018) Bahjat F. Marayati et al.   GENETICS

Consequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence

(2018) Emilie Lukášová et al.   Cells

HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX

(2018) Jonathan Nye et al.   PLoS One

Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP

(2018) Ewelina Zasadzińska et al.   DEVELOPMENTAL CELL

CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome

(2018) Motoko Unoki et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly

(2017) Valerie A. Schneider et al.   GENOME RESEARCH

Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points

(2017) Yael Nechemia-Arbely et al.   JOURNAL OF CELL BIOLOGY

Chromatin dynamics during the cell cycle at centromeres

(2017) Sebastian Müller et al.   NATURE REVIEWS GENETICS

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

(2017) Simona Giunta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

(2017) Cristian Tomasetti et al.   SCIENCE

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

(2017) Minh Bui et al.   Epigenetics & Chromatin

MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

(2017) Xianning Lai et al.   Nature Communications

RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin

(2017) Whitney L Johnson et al.   eLife

Solving the Telomere Replication Problem

(2017) Laetitia Maestroni et al.   Genes

CENP-A chromatin disassembly in stressed and senescent murine cells

(2017) Sabrine Hédouin et al.   Scientific Reports

Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles

(2016) Megan E. Aldrup-MacDonald et al.   GENOME RESEARCH

Elevated expression of the centromere protein-A(CENP-A)-encoding gene as a prognostic and predictive biomarker in human cancers

(2016) Xia Sun et al.   INTERNATIONAL JOURNAL OF CANCER

RNA Processing and Genome Stability: Cause and Consequence

(2016) Vihandha O. Wickramasinghe et al.   MOLECULAR CELL

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

(2016) Fatima Cardoso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

(2016) Weiguo Zhang et al.   Nature Communications

Replication, checkpoint suppression and structure of centromeric DNA

(2016) Francesco Romeo et al.   Nucleus

Replication, checkpoint suppression and structure of centromeric DNA

(2016) Francesco Romeo et al.   Nucleus

CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells

(2016) Seung-Hee Lee et al.   Aging-US

Centromeric Alpha-Satellite DNA Adopts Dimeric i-Motif Structures Capped by AT Hoogsteen Base Pairs

(2015) Miguel Garavís et al.   CHEMISTRY-A EUROPEAN JOURNAL

Silencing of active transposable elements in plants

(2015) Dalen Fultz et al.   CURRENT OPINION IN PLANT BIOLOGY

CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere

(2015) Yohei Niikura et al.   DEVELOPMENTAL CELL

Dynamic Phosphorylation of CENP-A at Ser68 Orchestrates Its Cell-Cycle-Dependent Deposition at Centromeres

(2015) Zhouliang Yu et al.   DEVELOPMENTAL CELL

Identification of the Post-translational Modifications Present in Centromeric Chromatin

(2015) Aaron O. Bailey et al.   MOLECULAR & CELLULAR PROTEOMICS

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer

(2015) Francesca Bersani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells

(2015) Rajbir K Athwal et al.   Epigenetics & Chromatin

Constitutive heterochromatin formation and transcription in mammals

(2015) Nehmé Saksouk et al.   Epigenetics & Chromatin

Mutations in CDCA7 and HELLS cause immunodeficiency–centromeric instability–facial anomalies syndrome

(2015) Peter E. Thijssen et al.   Nature Communications

The structure of an endogenous Drosophila centromere reveals the prevalence of tandemly repeated sequences able to form i-motifs

(2015) Miguel Garavís et al.   Scientific Reports

The Architecture and Evolution of Cancer Neochromosomes

(2014) Dale W. Garsed et al.   CANCER CELL

Centromere identity from the DNA point of view

(2014) Miroslav Plohl et al.   CHROMOSOMA

Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly

(2014) Tetsuya Hori et al.   DEVELOPMENTAL CELL

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

Centromere reference models for human chromosomes X and Y satellite arrays

(2014) K. H. Miga et al.   GENOME RESEARCH

Mislocalization of the Centromeric Histone Variant CenH3/CENP-A in Human Cells Depends on the Chaperone DAXX

(2014) Nicolas Lacoste et al.   MOLECULAR CELL

Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae

(2014) W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Characterization of Large Heterochromatic Gaps in the Human Genome Assembly

(2014) Nicolas Altemose et al.   PLoS Computational Biology

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

(2013) Eric C. Swanson et al.   JOURNAL OF CELL BIOLOGY

Aneuploidy in health, disease, and aging

(2013) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

A two-step mechanism for epigenetic specification of centromere identity and function

(2013) Daniele Fachinetti et al.   NATURE CELL BIOLOGY

Prognostic value of centromere protein-A expression in patients with epithelial ovarian cancer

(2013) Jun-Jun Qiu et al.   TUMOR BIOLOGY

R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli

(2013) Hallie Wimberly et al.   Nature Communications

Cell-Cycle-Dependent Structural Transitions in the Human CENP-A Nucleosome In Vivo

(2012) Minh Bui et al.   CELL

Neocentromeres and epigenetically inherited features of centromeres

(2012) Laura S. Burrack et al.   CHROMOSOME RESEARCH

Retrotransposon insertion targeting: a mechanism for homogenization of centromere sequences on nonhomologous chromosomes

(2012) J. A. Birchler et al.   GENES & DEVELOPMENT

Centromere-targeted de novo integrations of an LTR retrotransposon of Arabidopsis lyrata

(2012) S. Tsukahara et al.   GENES & DEVELOPMENT

Functional genomic analysis of chromosomal aberrations in a compendium of 8000 cancer genomes

(2012) T.-M. Kim et al.   GENOME RESEARCH

Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function

(2012) J. H. Bergmann et al.   JOURNAL OF CELL SCIENCE

Expression and prognostic significance of centromere protein A in human lung adenocarcinoma

(2012) Qing Wu et al.   LUNG CANCER

Sequences Associated with Centromere Competency in the Human Genome

(2012) K. E. Hayden et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription as a source of genome instability

(2012) Nayun Kim et al.   NATURE REVIEWS GENETICS

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in ZBTB24 Are Associated with Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome Type 2

(2011) Jessica C. de Greef et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas

(2011) C. Martinez-A et al.   CARCINOGENESIS

Give me a break, but not in mitosis

(2011) Simona Giunta et al.   CELL CYCLE

Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast

(2011) Takehiko Kobayashi   CELLULAR AND MOLECULAR LIFE SCIENCES

Formation of novel CENP-A domains on tandem repetitive DNA and across chromosome breakpoints on human chromosome 8q21 neocentromeres

(2011) Dan Hasson et al.   CHROMOSOMA

Endogenous Transcription at the Centromere Facilitates Centromere Activity in Budding Yeast

(2011) Kentaro Ohkuni et al.   CURRENT BIOLOGY

Organization and Molecular Evolution of CENP-A–Associated Satellite DNA Families in a Basal Primate Genome

(2011) Hye-Ran Lee et al.   Genome Biology and Evolution

ShRNA-Targeted Centromere Protein A Inhibits Hepatocellular Carcinoma Growth

(2011) Yongmei Li et al.   PLoS One

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Drosophila CENH3 Is Sufficient for Centromere Formation

(2011) M. J. Mendiburo et al.   SCIENCE

Assembly of Drosophila Centromeric Chromatin Proteins during Mitosis

(2011) Barbara G. Mellone et al.   PLoS Genetics

H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G1phase

(2011) Elaine M. Dunleavy et al.   Nucleus

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

(2010) Julia M. Sidorova et al.   CELL CYCLE

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

1q12 chromosome translocations form aberrant heterochromatic foci associated with changes in nuclear architecture and gene expression in B cell lymphoma

(2010) Alexandra Fournier et al.   EMBO Molecular Medicine

DNA damage signaling in response to double-strand breaks during mitosis

(2010) Simona Giunta et al.   JOURNAL OF CELL BIOLOGY

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division

(2010) L. H.-C. Wang et al.   JOURNAL OF CELL SCIENCE

CENP-A Reduction Induces a p53-Dependent Cellular Senescence Response To Protect Cells from Executing Defective Mitoses

(2010) K. Maehara et al.   MOLECULAR AND CELLULAR BIOLOGY

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A super-resolution map of the vertebrate kinetochore

(2010) S. A. Ribeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for recombination in centromere function

(2010) Ramsay J. McFarlane et al.   TRENDS IN GENETICS

Centromeres Convert but Don't Cross

(2010) Paul B. Talbert et al.   PLOS BIOLOGY

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Non-B DNA structure-induced genetic instability and evolution

(2009) Junhua Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CENPA overexpression promotes genome instability in pRb-depleted human cells

(2009) Angela Amato et al.   Molecular Cancer

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Double-strand DNA breaks recruit the centromeric histone CENP-A

(2009) S. G. Zeitlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA hypomethylation in cancer cells

(2009) Melanie Ehrlich   Epigenomics

Epigenetic regulation of heterochromatic DNA stability

(2008) Jamy C Peng et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Centromere mitotic recombination in mammalian cells

(2008) Isabel Jaco et al.   JOURNAL OF CELL BIOLOGY

Epigenetics regulate centromere formation and kinetochore function

(2008) Randall S. Gieni et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hairpin structures formed by alpha satellite DNA of human centromeres are cleaved by human topoisomerase II 

(2008) A. T. Jonstrup et al.   NUCLEIC ACIDS RESEARCH

Molecular architecture of the kinetochore–microtubule interface

(2007) Iain M. Cheeseman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY