Oncogenic lncRNAs alter epigenetic memory at a fragile chromosomal site in human cancer cells

Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids

(2021) John A. Smolka et al.   JOURNAL OF CELL BIOLOGY

RNA promotes the formation of spatial compartments in the nucleus

(2021) Sofia A. Quinodoz et al.   CELL

BRCA1 prevents R-loop-associated centromeric instability

(2021) Carine Racca et al.   Cell Death & Disease

Minimal Cylinder Analysis Reveals the Mechanical Properties of Oncogenic Nucleosomes

(2020) Mary Pitman et al.   BIOPHYSICAL JOURNAL

Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize

(2020) Yalin Liu et al.   PLOS BIOLOGY

The role of the histone H3 variant CENPA in prostate cancer

(2020) Anjan K. Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomere-to-telomere assembly of a complete human X chromosome

(2020) Karen H. Miga et al.   NATURE

Centromeric Transcription: A Conserved Swiss-Army Knife

(2020) Ganesan Arunkumar et al.   Genes

Long Noncoding RNA PVT1 Is Regulated by Bromodomain Protein BRD4 in Multiple Myeloma and Is Associated with Disease Progression

(2020) Hiroshi Handa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

(2020) Fred C. Lam et al.   Nature Communications

R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast

(2020) Prashant K. Mishra et al.   MOLECULAR BIOLOGY OF THE CELL

Centromere Repeats: Hidden Gems of the Genome

(2019) Gabrielle Hartley et al.   Genes

The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo

(2019) Rebecca E. Andersen et al.   DEVELOPMENTAL CELL

Long noncoding RNA PCAT1, a novel serum-based biomarker, enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma

(2019) Lijie Huang et al.   Cell Death & Disease

Regulation of gene expression by cis-acting long non-coding RNAs

(2019) Noa Gil et al.   NATURE REVIEWS GENETICS

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1

(2019) Leonid Andronov et al.   Nature Communications

Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation

(2018) Georg O.M. Bobkov et al.   JOURNAL OF CELL BIOLOGY

Chromatin assembly factor-1 (CAF-1) chaperone regulates Cse4 deposition into chromatin in budding yeast

(2018) Geetha S Hewawasam et al.   NUCLEIC ACIDS RESEARCH

HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX

(2018) Jonathan Nye et al.   PLoS One

Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

(2018) Dominique Ray-Gallet et al.   Nature Communications

Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery

(2017) Yue Hu et al.   GENES CHROMOSOMES & CANCER

Transposable Elements in Human Cancer: Causes and Consequences of Deregulation

(2017) Sumadi Anwar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells

(2017) Roshan L. Shrestha et al.   Oncotarget

Decoding the centromeric nucleosome through CENP-N

(2017) Satyakrishna Pentakota et al.   eLife

Elevated expression of the centromere protein-A(CENP-A)-encoding gene as a prognostic and predictive biomarker in human cancers

(2016) Xia Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Mitotic noncoding RNA processing promotes kinetochore and spindle assembly inXenopus

(2016) Andrew W. Grenfell et al.   JOURNAL OF CELL BIOLOGY

Promiscuous Histone Mis-Assembly Is Actively Prevented by Chaperones

(2016) Haiqing Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals

(2016) Lionel A. Sanz et al.   MOLECULAR CELL

CENP-A and H3 Nucleosomes Display a Similar Stability to Force-Mediated Disassembly

(2016) Sung Hyun Kim et al.   PLoS One

Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

(2016) Weiguo Zhang et al.   Nature Communications

The major horse satellite DNA family is associated with centromere competence

(2016) Federico Cerutti et al.   Molecular Cytogenetics

Regulation of Budding Yeast CENP-A levels Prevents Misincorporation at Promoter Nucleosomes and Transcriptional Defects

(2016) Erica M. Hildebrand et al.   PLoS Genetics

Histone Variants and Epigenetics

(2015) Steven Henikoff et al.   Cold Spring Harbor Perspectives in Biology

CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells

(2015) Rajbir K Athwal et al.   Epigenetics & Chromatin

Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells

(2015) Biljana Stangeland et al.   Oncotarget

A unique chromatin complex occupies young  -satellite arrays of human centromeres

(2015) J. G. Henikoff et al.   Science Advances

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

(2014) Jian-Feng Xiang et al.   CELL RESEARCH

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

(2014) Taranjit Singh Rai et al.   GENES & DEVELOPMENT

Ectopic Centromere Nucleation by CENP-A in Fission Yeast

(2014) Marlyn Gonzalez et al.   GENETICS

The impact of chromosomal rearrangements on regulation of gene expression

(2014) L. Harewood et al.   HUMAN MOLECULAR GENETICS

Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division

(2014) Silvana Rošić et al.   JOURNAL OF CELL BIOLOGY

Mislocalization of the Centromeric Histone Variant CenH3/CENP-A in Human Cells Depends on the Chaperone DAXX

(2014) Nicolas Lacoste et al.   MOLECULAR CELL

Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3

(2014) Yasuhiro Arimura et al.   Scientific Reports

A long non-coding RNA is required for targeting centromeric protein A to the human centromere

(2014) Delphine Quénet et al.   eLife

Hypermorphic expression of centromeric retroelement-encoded small RNAs impairs CENP-A loading

(2013) Dawn M. Carone et al.   CHROMOSOME RESEARCH

Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape

(2013) Nikolay A. Pchelintsev et al.   Cell Reports

Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

(2012) Jun-ichirou Ohzeki et al.   EMBO JOURNAL

DNA-RNA hybrid formation mediates RNAi-directed heterochromatin formation

(2012) Mina Nakama et al.   GENES TO CELLS

The 8q24 Gene Desert: An Oasis of Non-Coding Transcriptional Activity

(2012) Konrad Huppi et al.   Frontiers in Genetics

Induced Ectopic Kinetochore Assembly Bypasses the Requirement for CENP-A Nucleosomes

(2011) Karen E. Gascoigne et al.   CELL

Structural organization of the kinetochore–microtubule interface

(2011) Jennifer G. DeLuca et al.   CURRENT OPINION IN CELL BIOLOGY

Making a long story short: noncoding RNAs and chromosome change

(2011) J D Brown et al.   HEREDITY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear Expression of KLF6 Tumor Suppressor Factor Is Highly Associated with Overexpression of ERBB2 Oncoprotein in Ductal Breast Carcinomas

(2010) Ricardo C. Gehrau et al.   PLoS One

HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres

(2010) M. Shuaib et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential mechanisms of endogenous retroviral-mediated genomic instability in human cancer

(2010) M.T. Romanish et al.   SEMINARS IN CANCER BIOLOGY

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase

(2009) Federica Ferri et al.   NUCLEIC ACIDS RESEARCH