Essential role for centromeric factors following p53 loss and oncogenic transformation

A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly

(2017) Ana Stankovic et al.   MOLECULAR CELL

Chromatin dynamics during the cell cycle at centromeres

(2017) Sebastian Müller et al.   NATURE REVIEWS GENETICS

Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion

(2016) Maria Sokolova et al.   CELL CYCLE

Elevated expression of the centromere protein-A(CENP-A)-encoding gene as a prognostic and predictive biomarker in human cancers

(2016) Xia Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks

(2016) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

(2016) D. Fang et al.   SCIENCE

p53 downregulates the Fanconi anaemia DNA repair pathway

(2016) Sara Jaber et al.   Nature Communications

CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly

(2016) Sebastian Hoffmann et al.   Cell Reports

FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index

(2015) Christina Yau et al.   BREAST CANCER RESEARCH AND TREATMENT

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

(2015) Giovanni Ciriello et al.   CELL

Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major population-specific expansions

(2015) Željka Pezer et al.   GENOME RESEARCH

p53 protects against genome instability following centriole duplication failure

(2015) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells

(2015) Rajbir K Athwal et al.   Epigenetics & Chromatin

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

(2015) Akihiro Ohashi et al.   Nature Communications

Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells

(2015) Xuan Zhang et al.   Oncotarget

Histone H3 Variants and Their Chaperones During Development and Disease: Contributing to Epigenetic Control

(2014) Dan Filipescu et al.   Annual Review of Cell and Developmental Biology

The histone variant composition of centromeres is controlled by the pericentric heterochromatin state during the cell cycle

(2014) Ekaterina Boyarchuk et al.   JOURNAL OF CELL SCIENCE

Mislocalization of the Centromeric Histone Variant CenH3/CENP-A in Human Cells Depends on the Chaperone DAXX

(2014) Nicolas Lacoste et al.   MOLECULAR CELL

The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma

(2014) Rocío Montes de Oca et al.   Molecular Oncology

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Expression and prognostic relevance of centromere protein A in primary osteosarcoma

(2014) Xiao-Min Gu et al.   PATHOLOGY RESEARCH AND PRACTICE

Alisertib Added to Rituximab and Vincristine Is Synthetic Lethal and Potentially Curative in Mice with Aggressive DLBCL Co-Overexpressing MYC and BCL2

(2014) Daruka Mahadevan et al.   PLoS One

Phosphorylation and DNA Binding of HJURP Determine Its Centromeric Recruitment and Function in CenH3CENP-A Loading

(2014) Sebastian Müller et al.   Cell Reports

A network of players in H3 histone variant deposition and maintenance at centromeres

(2013) Sebastian Müller et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

First Molecular Cytogenetic High Resolution Characterization of the NIH 3T3 Cell Line by Murine Multicolor Banding

(2013) Christine Leibiger et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

HJURP Regulates Cellular Senescence in Human Fibroblasts and Endothelial Cells Via a p53-Dependent Pathway

(2013) J.-I. Heo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Identification of cell cycle–regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors

(2013) Gavin D. Grant et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting FoxM1 Effectively Retards p53-Null Lymphoma and Sarcoma

(2013) Z. Wang et al.   MOLECULAR CANCER THERAPEUTICS

A two-step mechanism for epigenetic specification of centromere identity and function

(2013) Daniele Fachinetti et al.   NATURE CELL BIOLOGY

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

(2013) E K Benson et al.   ONCOGENE

Modulation of HJURP (Holliday Junction-Recognizing Protein) Levels Is Correlated with Glioblastoma Cells Survival

(2013) Valeria Valente et al.   PLoS One

Prognostic Significance of EDN/RB, HJURP, p60/CAF-1 and PDLI4, Four New Markers in High-Grade Gliomas

(2013) Marie de Tayrac et al.   PLoS One

Prognostic value of centromere protein-A expression in patients with epithelial ovarian cancer

(2013) Jun-Jun Qiu et al.   TUMOR BIOLOGY

Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes

(2013) Iva Simeonova et al.   Cell Reports

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

p53 can repress transcription of cell cycle genes through a p21WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

(2012) Marianne Quaas et al.   CELL CYCLE

Expression and prognostic significance of centromere protein A in human lung adenocarcinoma

(2012) Qing Wu et al.   LUNG CANCER

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Heterochromatin instability in cancer: From the Barr body to satellites and the nuclear periphery

(2012) Dawn M. Carone et al.   SEMINARS IN CANCER BIOLOGY

A unified phylogeny-based nomenclature for histone variants

(2012) Paul B Talbert et al.   Epigenetics & Chromatin

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

(2011) Valentina Boeva et al.   BIOINFORMATICS

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Cdk Activity Couples Epigenetic Centromere Inheritance to Cell Cycle Progression

(2011) Mariana C.C. Silva et al.   DEVELOPMENTAL CELL

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

ShRNA-Targeted Centromere Protein A Inhibits Hepatocellular Carcinoma Growth

(2011) Yongmei Li et al.   PLoS One

Control-free calling of copy number alterations in deep-sequencing data using GC-content normalization

(2010) Valentina Boeva et al.   BIOINFORMATICS

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

A Strand-Specific Burst in Transcription of Pericentric Satellites Is Required for Chromocenter Formation and Early Mouse Development

(2010) Aline.V. Probst et al.   DEVELOPMENTAL CELL

Clinical significance and prognostic value of chromatin assembly factor-1 overexpression in human solid tumours

(2010) Sophie E Polo et al.   HISTOPATHOLOGY

CENP-A Reduction Induces a p53-Dependent Cellular Senescence Response To Protect Cells from Executing Defective Mitoses

(2010) K. Maehara et al.   MOLECULAR AND CELLULAR BIOLOGY

HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres

(2010) M. Shuaib et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

Heat Shock Factor 1-Mediated Aneuploidy Requires a Defective Function of p53

(2009) E.-H. Kim et al.   CANCER RESEARCH

Chromosome segregation machinery and cancer

(2009) Kozo Tanaka et al.   CANCER SCIENCE

HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres

(2009) Elaine M. Dunleavy et al.   CELL

Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP

(2009) Daniel R. Foltz et al.   CELL

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Inhibition of Aurora B kinase sensitizes a subset of human glioma cells to TRAIL concomitant with induction of TRAIL-R2

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

Epigenetic regulation of centromeric chromatin: old dogs, new tricks?

(2008) Robin C. Allshire et al.   NATURE REVIEWS GENETICS