The CLDN5 gene at the blood-brain barrier in health and disease

Single-cell dissection of the human brain vasculature

(2022) Francisco J. Garcia et al.   NATURE

Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders

(2022) Maud Martin et al.   SCIENCE

TRPV4: A trigger of pathological RhoA activation in neurological disease

(2022) Anna M. Bagnell et al.   BIOESSAYS

P213. Vascular and Blood-Brain Barrier-Related Changes Underlie Stress Responses and Resilience in Female Mice and Depression in Human Tissue

(2022) Laurence Dion-Albert et al.   BIOLOGICAL PSYCHIATRY

Cingulin binds to the ZU5 domain of scaffolding protein ZO-1 to promote its extended conformation, stabilization, and tight junction accumulation

(2022) Ekaterina Vasileva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling

(2022) Saranyaraajan Varadarajan et al.   JOURNAL OF CELL BIOLOGY

Imaging the inflammatory phenotype in migraine

(2022) Rune Häckert Christensen et al.   JOURNAL OF HEADACHE AND PAIN

Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis

(2022) Yongguo Zhang et al.   Mucosal Immunology

Adenosine signaling activates ATP-sensitive K + channels in endothelial cells and pericytes in CNS capillaries

(2022) Maria Sancho et al.   Science Signaling

Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

(2022) Chris Greene et al.   Nature Communications

Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood–Brain Barrier Tight Junctions

(2022) Alessandro Berselli et al.   ACS Chemical Neuroscience

Autosomal recessive congenital ichthyosis caused by a pathogenic missense variant in CLDN1

(2022) Janan Mohamad et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Tight junction formation by a claudin mutant lacking the COOH‐terminal PDZ domain‐binding motif

(2022) Sachiko Fujiwara et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Recurrent de novo mutations in CLDN5 induce an anion-selective blood–brain barrier and alternating hemiplegia

(2022) Yosuke Hashimoto et al.   BRAIN

Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction

(2022) Lu Wang et al.   CIRCULATION RESEARCH

Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner

(2022) Mark Richards et al.   eLife

Nanoscale segregation of channel and barrier claudins enables paracellular ion flux

(2022) Hannes Gonschior et al.   Nature Communications

Variants in CLDN5 cause a syndrome characterized by seizures, microcephaly and brain calcifications

(2022) Ashish R Deshwar et al.   BRAIN

Brain DNA Methylation Patterns in CLDN5 Associated with Cognitive Decline

(2021) Anke Hüls et al.   BIOLOGICAL PSYCHIATRY

Sex-Related Differences in Regional Blood–Brain Barrier Integrity in Non-Demented Elderly Subjects

(2021) Yeonsil Moon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate

(2021) Tyler M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variants of human CLDN9 cause mild to profound hearing loss

(2021) Memoona Ramzan et al.   HUMAN MUTATION

Angulin-1 seals tricellular contacts independently of tricellulin and claudins

(2021) Taichi Sugawara et al.   JOURNAL OF CELL BIOLOGY

Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood–brain barrier permeability for drug delivery to the brain in a non-human primate

(2021) Keisuke Tachibana et al.   JOURNAL OF CONTROLLED RELEASE

Adenosine A2A receptor activation enhances blood-tumor barrier permeability in a rodent glioma model

(2021) Amelie Vezina et al.   MOLECULAR CANCER RESEARCH

Genotype–Phenotype Relations in Primary Familial Brain Calcification: Systematic MDSGene Review

(2021) Alexander Balck et al.   MOVEMENT DISORDERS

Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences

(2021) K. Shaw et al.   Nature Communications

Circumventing the packaging limit of AAV-mediated gene replacement therapy for neurological disorders

(2021) Lara Marrone et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cholesterol-Induced Suppression of Endothelial Kir Channels Is a Driver of Impairment of Arteriolar Flow-Induced Vasodilation in Humans

(2021) Sang Joon Ahn et al.   HYPERTENSION

Endothelial sphingosine-1-phosphate receptor 4 regulates blood-brain barrier permeability and promotes a homeostatic endothelial phenotype

(2021) Lena Hansen et al.   JOURNAL OF NEUROSCIENCE

Tbx1, a gene encoded in 22q11.2 copy number variant, is a link between alterations in fimbria myelination and cognitive speed in mice

(2021) Takeshi Hiramoto et al.   MOLECULAR PSYCHIATRY

S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy

(2021) Michael Amoo et al.   NEUROSURGICAL REVIEW

Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner

(2020) C. Hempel et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression

(2020) Katarzyna A. Dudek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice

(2020) Jan Wenzel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance

(2020) Filip Roudnicky et al.   Scientific Reports

GDF15 promotes simultaneous astrocyte remodeling and tight junction strengthening at the blood–brain barrier

(2020) Victoria A. Malik et al.   JOURNAL OF NEUROSCIENCE RESEARCH

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

CO-MORBIDITY BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA: PREVALENCE AND CLINICAL CHARACTERISTICS

(2020) Abdulbari Bener et al.   Psychiatria Danubina

Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

(2020) Ross O Smith et al.   eLife

Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

(2020) Vincenza Caolo et al.   eLife

JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function

(2020) Nikolaos Kakogiannos et al.   CIRCULATION RESEARCH

G Protein-Coupled Receptors in the Mammalian Blood-Brain Barrier

(2020) Brock R. Pluimer et al.   Frontiers in Cellular Neuroscience

Increase in blood–brain barrier leakage in healthy, older adults

(2020) Inge C. M. Verheggen et al.   GeroScience

Incidence of Parkinson’s disease, dementia, cerebrovascular disease and stroke in bipolar disorder compared to other psychiatric disorders: an electronic health records network study of 66 million people

(2020) Paul J Harrison et al.   BIPOLAR DISORDERS

Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model

(2020) Macayla L. Donegan et al.   NATURE NEUROSCIENCE

Shear stress induces pathological changes in endothelial cells through Piezo1 activation of TRPV4

(2020) Sandip M. Swain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood–Brain Barrier Leakage Is Increased in Parkinson’s Disease

(2020) Sarah Al-Bachari et al.   Frontiers in Physiology

Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells

(2020) Silvia Dragoni et al.   Cells

ALK-1 to ALK-5 ratio dictated by the Akt1-β-catenin pathway regulates TGFβ-induced endothelial-to-mesenchymal transition

(2020) Arti Verma et al.   GENE

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Morphologic determinant of tight junctions revealed by claudin-3 structures

(2019) Shun Nakamura et al.   Nature Communications

Cellular and Molecular Differences Between Area CA1 and the Dentate Gyrus of the Hippocampus

(2019) Karim A Alkadhi   MOLECULAR NEUROBIOLOGY

Rho Flares Repair Local Tight Junction Leaks

(2019) Rachel E. Stephenson et al.   DEVELOPMENTAL CELL

Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

(2019) Andras Iring et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a missense variant in CLDN2 in obstructive azoospermia

(2019) Masomeh Askari et al.   JOURNAL OF HUMAN GENETICS

Newly synthesized claudins but not occludin are added to the basal side of the tight junction

(2019) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

The neuritic plaque in Alzheimer's disease: Perivascular degeneration of neuronal processes

(2019) Gurpreet Kaur Hansra et al.   NEUROBIOLOGY OF AGING

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity

(2019) Tetsuhisa Otani et al.   JOURNAL OF CELL BIOLOGY

GPR55-mediated effects on brain microvascular endothelial cells and the blood–brain barrier

(2019) Luciana M. Leo et al.   NEUROSCIENCE

Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown

(2019) Alex J. Vecchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Claudin-12 is not required for blood–brain barrier tight junction function

(2019) Mariana Castro Dias et al.   Fluids and Barriers of the CNS

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

Management of Alternating Hemiplegia of Childhood: A Review

(2019) Debopam Samanta   PEDIATRIC NEUROLOGY

Blood-brain barrier imaging as a potential biomarker for bipolar disorder progression

(2019) Lyna Kamintsky et al.   NeuroImage-Clinical

Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification

(2019) Zhidong Cen et al.   BRAIN

Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art

(2019) Celeste Silveira et al.   Psychiatry Investigation

Phosphodiesterase Type 4 Inhibition in CNS Diseases

(2019) Arjan Blokland et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

BMP (Bone Morphogenetic Protein) 9/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability

(2018) Naoufal Akla et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis

(2018) Silvia Tietz et al.   BRAIN BEHAVIOR AND IMMUNITY

Hippocampal calcification on brain CT: prevalence and risk factors in a cerebrovascular cohort

(2018) Remko Kockelkoren et al.   EUROPEAN RADIOLOGY

Prolonged activation of cAMP signaling leads to endothelial barrier disruption via transcriptional repression of RRAS

(2018) Carole Y. Perrot et al.   FASEB JOURNAL

Molecular determination of claudin-15 organization and channel selectivity

(2018) Priyanka Samanta et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

(2018) Christine Q. Simmons et al.   NEUROBIOLOGY OF DISEASE

A comprehensive catalog of predicted functional upstream open reading frames in humans

(2018) Patrick McGillivray et al.   NUCLEIC ACIDS RESEARCH

Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2depletion

(2018) Osama F. Harraz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

(2018) Osama F Harraz et al.   eLife

Hypokalemia Associated With a Claudin 10 Mutation: A Case Report

(2018) Nicole Meyers et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Interictal psychiatric comorbidities of drug-resistant focal epilepsy: Prevalence and influence of the localization of the epilepsy

(2018) Claire Jansen et al.   EPILEPSY & BEHAVIOR

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling

(2018) Kathleen Hübner et al.   Nature Communications

Multiplex epithelium dysfunction due to CLDN10 mutation: the HELIX syndrome

(2017) Smail Hadj-Rabia et al.   GENETICS IN MEDICINE

Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex

(2017) Roger I Grant et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Characterization of the Ionic Profile of the Extracellular Space of the Injured and Ischemic Brain: A Microdialysis Study

(2017) Tamara Martínez-Valverde et al.   JOURNAL OF NEUROTRAUMA

Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model

(2017) Yosuke Hashimoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients withCLDN10Mutations

(2017) Ernie M.H.F. Bongers et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1

(2017) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Genetic risk for schizophrenia and psychosis in Alzheimer disease

(2017) M A A DeMichele-Sweet et al.   MOLECULAR PSYCHIATRY

Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia

(2017) C Greene et al.   MOLECULAR PSYCHIATRY

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

Social stress induces neurovascular pathology promoting depression

(2017) Caroline Menard et al.   NATURE NEUROSCIENCE

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

(2017) Keisuke Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD146 coordinates brain endothelial cell–pericyte communication for blood–brain barrier development

(2017) Jianan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural differences in hippocampal subfields among schizophrenia patients, major depressive disorder patients, and healthy subjects

(2017) Miho Ota et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry

(2017) Remco N. P. Rodenburg et al.   Nature Communications

Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage

(2017) Joakim Klar et al.   PLoS Genetics

VE-Cadherin–Mediated Epigenetic Regulation of Endothelial Gene Expression

(2017) Marco F. Morini et al.   CIRCULATION RESEARCH

A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations

(2017) Giulio Alberini et al.   PLoS One

Differences in the molecular structure of the blood-brain barrier in the cerebral cortex and white matter: an in silico, in vitro, and ex vivo study

(2016) Ádám Nyúl-Tóth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

(2016) U. Vazana et al.   JOURNAL OF NEUROSCIENCE

Inwardly rectifying K+channels are major contributors to flow-induced vasodilatation in resistance arteries

(2016) Sang Joon Ahn et al.   JOURNAL OF PHYSIOLOGY-LONDON

Estimated cognitive decline in patients with schizophrenia: A multicenter study

(2016) Haruo Fujino et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Low-Dose Lithium Stabilizes Human Endothelial Barrier by Decreasing MLC Phosphorylation and Universally Augments Cholinergic Vasorelaxation Capacity in a Direct Manner

(2016) Bert Bosche et al.   Frontiers in Physiology

Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin

(2016) Takehiro Shinoda et al.   Scientific Reports

Bradykinin increased the permeability of BTB via NOS/NO/ZONAB-mediating down-regulation of claudin-5 and occludin

(2015) Li-bo Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis

(2015) S. Flemming et al.   CARDIOVASCULAR RESEARCH

Molecular basis of claudin-17 anion selectivity

(2015) Marcel P. Conrad et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5

(2015) Yin-Sha Miao et al.   CELLULAR SIGNALLING

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

(2015) Olga Tornavaca et al.   JOURNAL OF CELL BIOLOGY

Model for the Architecture of Claudin-Based Paracellular Ion Channels through Tight Junctions

(2015) Hiroshi Suzuki et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Architecture of the Blood Brain Barrier Tight Junction Proteins–A Synergistic Computational and In Vitro Approach

(2015) Flaviyan Jerome Irudayanathan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

(2015) Xing-Lin Tan et al.   Molecular Neurodegeneration

Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

(2015) L Schmaal et al.   MOLECULAR PSYCHIATRY

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Clinical profile of patients with ATP1A3 mutations in Alternating Hemiplegia of Childhood—a study of 155 patients

(2015) Eleni Panagiotakaki et al.   Orphanet Journal of Rare Diseases

Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin

(2015) Y. Saitoh et al.   SCIENCE

Integrin β1 controls VE-cadherin localization and blood vessel stability

(2015) Hiroyuki Yamamoto et al.   Nature Communications

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

(2015) Constantinos M. Mikelis et al.   Nature Communications

Cognitive Decline Preceding the Onset of Psychosis in Patients With 22q11.2 Deletion Syndrome

(2015) Jacob A. S. Vorstman et al.   JAMA Psychiatry

Autoregulated paracellular clearance of amyloid-  across the blood-brain barrier

(2015) J. Keaney et al.   Science Advances

Claudin-3 and Claudin-5 Protein Folding and Assembly into the Tight Junction Are Controlled by Non-conserved Residues in the Transmembrane 3 (TM3) and Extracellular Loop 2 (ECL2) Segments

(2014) Jan Rossa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sox18 Preserves the Pulmonary Endothelial Barrier Under Conditions of Increased Shear Stress

(2014) Christine M. Gross et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Distinct neurological disorders with ATP1A3 mutations

(2014) Erin L Heinzen et al.   LANCET NEUROLOGY

Mechanisms of transcriptional activation of the mouse claudin-5 promoter by estrogen receptor alpha and beta

(2014) Malgorzata Burek et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions

(2014) H. Suzuki et al.   SCIENCE

Bicarbonate disruption of the pulmonary endothelial barrier via activation of endogenous soluble adenylyl cyclase, isoform 10

(2013) Boniface Obiako et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

cAMP with other signaling cues converges on Rac1 to stabilize the endothelial barrier— a signaling pathway compromised in inflammation

(2013) Nicolas Schlegel et al.   CELL AND TISSUE RESEARCH

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

Krüppel-Like Factor 4 Regulates Blood-Tumor Barrier Permeability via ZO-1, Occludin and Claudin-5

(2013) Jun Ma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

(2013) Annika Keller et al.   NATURE GENETICS

Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

(2013) Servio H. Ramirez et al.   PLoS One

Adaptive Induction of Growth Differentiation Factor 15 Attenuates Endothelial Cell Apoptosis in Response to High Glucose Stimulus

(2013) Jun Li et al.   PLoS One

Novel CLDN14 mutations in Pakistani families with autosomal recessive non-syndromic hearing loss

(2012) Kwanghyuk Lee et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions

(2012) F. Itoh et al.   BLOOD

Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells

(2012) C. Giampietro et al.   BLOOD

PKCα Activation of p120-Catenin Serine 879 Phospho-Switch Disassembles VE-Cadherin Junctions and Disrupts Vascular Integrity

(2012) Emily Vandenbroucke St Amant et al.   CIRCULATION RESEARCH

ETS-related Gene (ERG) Controls Endothelial Cell Permeability via Transcriptional Regulation of the Claudin 5 (CLDN5) Gene

(2012) Lei Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

(2012) Sandra Iden et al.   JOURNAL OF CELL BIOLOGY

In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

(2012) J. Cording et al.   JOURNAL OF CELL SCIENCE

The ubiquitin-proteasome pathway regulates claudin 5 degradation

(2012) Ilana Mandel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study

(2012) Hendrik Rosewich et al.   LANCET NEUROLOGY

De novo mutations in ATP1A3 cause alternating hemiplegia of childhood

(2012) Erin L Heinzen et al.   NATURE GENETICS

Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification

(2012) G. Nicolas et al.   NEUROLOGY

Junctional Adhesion Molecule (JAM)-C Deficient C57BL/6 Mice Develop a Severe Hydrocephalus

(2012) Lena Wyss et al.   PLoS One

Emerging themes of cAMP regulation of the pulmonary endothelial barrier

(2011) Sarah L. Sayner   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pericyte-Derived Sphinogosine 1-Phosphate Induces the Expression of Adhesion Proteins and Modulates the Retinal Endothelial Cell Barrier

(2011) Paul G. McGuire et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Elucidating the principles of the molecular organization of heteropolymeric tight junction strands

(2011) Jörg Piontek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TNF-alpha induced NFκB signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells

(2011) Muhammad Aslam et al.   CYTOKINE

LSR defines cell corners for tricellular tight junction formation in epithelial cells

(2011) S. Masuda et al.   JOURNAL OF CELL SCIENCE

Transcription and translation of human F11R gene are required for an initial step of atherogenesis induced by inflammatory cytokines

(2011) Bani M Azari et al.   Journal of Translational Medicine

Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion

(2011) Liam J. Drew et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

The Mouse Primary Visual Cortex Is a Site of Production and Sensitivity to Estrogens

(2011) Jin-Kwon Jeong et al.   PLoS One

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Recessive Mutations in the Gene Encoding the Tight Junction Protein Occludin Cause Band-like Calcification with Simplified Gyration and Polymicrogyria

(2010) Mary C. O'Driscoll et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Homozygous Mutation in the Tight-Junction Protein JAM3 Causes Hemorrhagic Destruction of the Brain, Subependymal Calcification, and Congenital Cataracts

(2010) Ganeshwaran H. Mochida et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Krüppel-Like Factor-4 Transcriptionally Regulates VE-Cadherin Expression and Endothelial Barrier Function

(2010) Colleen E. Cowan et al.   CIRCULATION RESEARCH

Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability

(2010) Sarah N. Rampersad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

R-Ras interacts with filamin a to maintain endothelial barrier function

(2010) G.S. Griffiths et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The evolution of depression and suicidality in first episode psychosis

(2009) R. Upthegrove et al.   ACTA PSYCHIATRICA SCANDINAVICA

Claudin-5 as a Novel Estrogen Target in Vascular Endothelium

(2009) Malgorzata Burek et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells

(2009) Guadalupe Villarreal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription

(2009) Mei Nie et al.   EMBO REPORTS

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells

(2008) Masaru Yamamoto et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin

(2008) G. M. Birdsey et al.   BLOOD

The RapGEF PDZ-GEF2 is required for maturation of cell–cell junctions

(2008) Nadia Dubé et al.   CELLULAR SIGNALLING

Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo

(2008) Elizabeth J. Westgate et al.   CIRCULATION

Integrin β1 Subunit Controls Mural Cell Adhesion, Spreading, and Blood Vessel Wall Stability

(2008) Sabu Abraham et al.   CIRCULATION RESEARCH

VE-cadherin is a critical endothelial regulator of TGF-β signalling

(2008) Noemi Rudini et al.   EMBO JOURNAL

Glucocorticoids induce transactivation of tight junction genes occludin and claudin-5 in retinal endothelial cells via a novel cis-element

(2008) Edward A. Felinski et al.   EXPERIMENTAL EYE RESEARCH

Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells

(2008) Malgorzata Milkiewicz et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RNAi-mediated reversible opening of the blood-brain barrier

(2008) Matthew Campbell et al.   JOURNAL OF GENE MEDICINE

Cloning and characterization of the murine claudin-5 promoter

(2008) Malgorzata Burek et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

(2008) Shigetomo Fukuhara et al.   NATURE CELL BIOLOGY

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

(2008) Andrea Taddei et al.   NATURE CELL BIOLOGY

Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia

(2008) Jun Li et al.   NEUROSCIENCE LETTERS

SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function

(2007) Ruud D. Fontijn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Formation of tight junction: determinants of homophilic interaction between classic claudins

(2007) Jörg Piontek et al.   FASEB JOURNAL