PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2depletion

(2018) Osama F. Harraz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F

(2018) Wenlei Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Calcium and electrical dynamics in lymphatic endothelium

(2017) Erik J. Behringer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

Nitric Oxide–Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries

(2017) Corina Marziano et al.   Journal of the American Heart Association

Contributions of protein kinases and β-arrestin to termination of protease-activated receptor 2 signaling

(2016) Seung-Ryoung Jung et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPV4: Molecular Conductor of a Diverse Orchestra

(2016) John P. M. White et al.   PHYSIOLOGICAL REVIEWS

Phosphoinositides regulate ion channels

(2015) Bertil Hille et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex

(2015) A. Lacroix et al.   JOURNAL OF NEUROSCIENCE

Vascular Inward Rectifier K+Channels as External K+Sensors in the Control of Cerebral Blood Flow

(2015) Thomas A. Longden et al.   MICROCIRCULATION

Transient Receptor Potential Channels in the Vasculature

(2015) Scott Earley et al.   PHYSIOLOGICAL REVIEWS

AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension

(2014) S. K. Sonkusare et al.   Science Signaling

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2

(2014) Nobuaki Takahashi et al.   Nature Communications

Quantitative properties and receptor reserve of the IP3and calcium branch of Gq-coupled receptor signaling

(2013) Eamonn J. Dickson et al.   JOURNAL OF GENERAL PHYSIOLOGY

The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow

(2013) Pablo Blinder et al.   NATURE NEUROSCIENCE

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

(2013) Anna Garcia-Elias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elementary Ca2+ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

(2012) S. K. Sonkusare et al.   SCIENCE

Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5)P2

(2011) Eleonora Zakharian et al.   FASEB JOURNAL

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force

(2010) Stephen Loukin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct and Specific Activation of Human Inward Rectifier K+Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

(2010) Nazzareno D'Avanzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Phosphoinositide regulation of non-canonical transient receptor potential channels

(2009) Tibor Rohacs   CELL CALCIUM

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Transient receptor potential channels meet phosphoinositides

(2008) Bernd Nilius et al.   EMBO JOURNAL

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections

(2008) J. Ledoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA