Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

Brain DNA Methylation Patterns in CLDN5 Associated with Cognitive Decline

(2021) Anke Hüls et al.   BIOLOGICAL PSYCHIATRY

Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?

(2020) Wolfgang Löscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells

(2020) Filip Roudnicky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes

(2020) Robert S. Pulido et al.   NEURON

The tight junction protein Claudin-5 limits endothelial cell motility

(2020) Zhenguo Yang et al.   JOURNAL OF CELL SCIENCE

Claudin-3-deficient C57BL/6J mice display intact brain barriers

(2019) Mariana Castro Dias et al.   Scientific Reports

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy

(2019) Sherice Williams et al.   MOLECULAR NEUROBIOLOGY

Dynamic blood brain barrier regulation in mild head trauma

(2019) Eoin O'Keeffe et al.   JOURNAL OF NEUROTRAUMA

Claudin-12 is not required for blood–brain barrier tight junction function

(2019) Mariana Castro Dias et al.   Fluids and Barriers of the CNS

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy

(2018) Dan Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy

(2018) Ralf G. Rempe et al.   JOURNAL OF NEUROSCIENCE

Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events

(2018) Naoki Honkura et al.   Nature Communications

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ

(2018) Kimberly Young et al.   Jove-Journal of Visualized Experiments

Evidence for peri-ictal blood–brain barrier dysfunction in patients with epilepsy

(2018) Theodor Rüber et al.   BRAIN

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia

(2017) C Greene et al.   MOLECULAR PSYCHIATRY

Social stress induces neurovascular pathology promoting depression

(2017) Caroline Menard et al.   NATURE NEUROSCIENCE

Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles

(2016) Debayon Paul et al.   Journal of Neuroinflammation

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

Blood–brain barrier dysfunction, seizures and epilepsy

(2015) E.A. van Vliet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

(2013) Maria Feldmann et al.   LANCET NEUROLOGY

The kainic acid model of temporal lobe epilepsy

(2013) Maxime Lévesque et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuropathology of the blood–brain barrier and pharmaco-resistance in human epilepsy

(2012) Joan Y. W. Liu et al.   BRAIN

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

(2012) Eva M Jimenez-Mateos et al.   NATURE MEDICINE

Systemic low-molecular weight drug delivery to pre-selected neuronal regions

(2011) Matthew Campbell et al.   EMBO Molecular Medicine

Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling Pathways

(2011) M. Morin-Brureau et al.   JOURNAL OF NEUROSCIENCE

Drug-Resistant Epilepsy

(2011) Patrick Kwan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blood-brain barrier damage and brain penetration of antiepileptic drugs: Role of serum proteins and brain edema

(2009) Nicola Marchi et al.   EPILEPSIA

Validation of Serum Markers for Blood-Brain Barrier Disruption in Traumatic Brain Injury

(2009) Brian J. Blyth et al.   JOURNAL OF NEUROTRAUMA

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE