Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells

Modulation of Inflammation by Extracellular Granzyme A

(2020) Kim R. van Daalen et al.   Frontiers in Immunology

Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors

(2020) Gunnar Pejler   Journal of Innate Immunity

The domino effect triggered by the tethered ligand of the protease activated receptors

(2020) Xu Han et al.   THROMBOSIS RESEARCH

Granzymes in cardiovascular injury and disease

(2020) Matthew R. Zeglinski et al.   CELLULAR SIGNALLING

Molecular basis of protease‐activated receptor 1 signalling diversity

(2019) Orla Willis‐Fox et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

(2018) Liqun He et al.   Scientific Data

Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release

(2018) Kerstin Göbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions

(2017) Silvia Dragoni et al.   JOURNAL OF IMMUNOLOGY

Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

(2017) Paul R. Lee et al.   Journal of Neuroinflammation

Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis

(2015) Marek Z. Wojtukiewicz et al.   CANCER AND METASTASIS REVIEWS

The regulation of transendothelial migration: new knowledge and new questions

(2015) William A. Muller   CARDIOVASCULAR RESEARCH

Protease activated receptor-1 antagonist ameliorates the clinical symptoms of experimental autoimmune encephalomyelitis via inhibiting breakdown of blood-brain barrier

(2015) Ha Neui Kim et al.   JOURNAL OF NEUROCHEMISTRY

Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo

(2015) Yohannes Haile et al.   Journal of Neuroinflammation

Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers

(2014) Natalie Hudson et al.   DEVELOPMENTAL CELL

Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin

(2014) Florian Wessel et al.   NATURE IMMUNOLOGY

Functional role of protease activated receptors in vascular biology

(2014) Maria Adele Alberelli et al.   VASCULAR PHARMACOLOGY

Biased Signaling of Protease-Activated Receptors

(2014) Peishen Zhao et al.   Frontiers in Endocrinology

Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)

(2013) Koichiro Mihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin induces an inflammatory phenotype in a human brain endothelial cell line

(2012) Leah M. Alabanza et al.   JOURNAL OF NEUROIMMUNOLOGY

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

(2010) J. Greenwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

(2009) F. Niessen et al.   BLOOD

Adapter and enzymatic functions of proteases in T-cell activation

(2009) Stephan Hailfinger et al.   IMMUNOLOGICAL REVIEWS

Proteases Display Biased Agonism at Protease-Activated Receptors: Location matters!

(2009) A. Russo et al.   MOLECULAR INTERVENTIONS

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

(2009) Ulf Schulze-Topphoff et al.   NATURE MEDICINE

ICAM-1–mediated Endothelial Nitric Oxide Synthase Activation via Calcium and AMP-activated Protein Kinase Is Required for Transendothelial Lymphocyte Migration

(2008) Roberta Martinelli et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration

(2007) P. Turowski et al.   JOURNAL OF CELL SCIENCE