The transcription regulator ATF4 is a mediator of skeletal muscle aging

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

(2022) Cyril Statzer et al.   Nature Communications

ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress

(2022) Xiaoding Wang et al.   CIRCULATION RESEARCH

Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR)

(2022) Johannes C. van der Mijn et al.   MOLECULAR CARCINOGENESIS

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

(2022) Dominik Saul et al.   Nature Communications

TurnoveR: A Skyline External Tool for Analysis of Protein Turnover in Metabolic Labeling Studies

(2022) Nathan Basisty et al.   JOURNAL OF PROTEOME RESEARCH

Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

(2021) Roberta Sartori et al.   Nature Communications

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

(2021) Margaret E Torrence et al.   eLife

Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction

(2021) Taejeong Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy

(2021) Scott M Ebert et al.   JOURNAL OF NUTRITION

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

(2021) Dylan Gerard Ryan et al.   eLife

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

(2021) Vanessa Byles et al.   Molecular Metabolism

Rho GTPases in Skeletal Muscle Development and Homeostasis

(2021) Sonia Rodríguez-Fdez et al.   Cells

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ

(2020) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IDH2 Deficiency Is Critical in Myogenesis and Fatty Acid Metabolism in Mice Skeletal Muscle

(2020) Jeong Hoon Pan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of Mitophagy and Mitochondrial Unfolded Protein Response as New Adaptive Mechanisms Underlying Old Pathologies: Sarcopenia and Non-Alcoholic Fatty Liver Disease

(2020) Rodrigo Urbina-Varela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis

(2020) Sonia Rodríguez-Fdez et al.   Nature Communications

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

(2019) Huibin Tang et al.   AGING CELL

The clinical impact and biological mechanisms of skeletal muscle aging

(2019) Zaira Aversa et al.   BONE

OBG ‐like ATP ase 1 inhibition attenuates angiotensin II ‐induced hypertrophic response in human ventricular myocytes via GSK ‐3beta/beta‐catenin signalling

(2019) Gayathri Narasimhan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

(2019) Shuping Zhang et al.   eLife

Skeletal Muscle Atrophy: Discovery of Mechanisms and Potential Therapies

(2019) Scott M. Ebert et al.   PHYSIOLOGY

Tryptophan Oxidation in the UQCRC1 Subunit of Mitochondrial Complex III (Ubiquinol-Cytochrome C Reductase) in a Mouse Model of Myodegeneration Causes Large Structural Changes in the Complex: A Molecular Dynamics Simulation Study

(2019) Sruthi Unni et al.   Scientific Reports

An Investigation of p53 in Skeletal Muscle Aging

(2019) Scott M. Ebert et al.   JOURNAL OF APPLIED PHYSIOLOGY

Accumulation of “Old Proteins” and the Critical Need for MS‐based Protein Turnover Measurements in Aging and Longevity

(2019) Nathan Basisty et al.   PROTEOMICS

MyoVision: software for automated high-content analysis of skeletal muscle immunohistochemistry

(2018) Yuan Wen et al.   JOURNAL OF APPLIED PHYSIOLOGY

De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver

(2018) Liping Luo et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

(2018) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Protein Turnover in Aging and Longevity

(2018) Nathan Basisty et al.   PROTEOMICS

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

(2018) Hannah Walters et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exercise training increases CISD family protein expression in murine skeletal muscle and white adipose tissue

(2018) Takumi Yokokawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myopathies Related to Glycogen Metabolism Disorders

(2018) Mark A. Tarnopolsky   Neurotherapeutics

Sarcopenia: Aging-Related Loss of Muscle Mass and Function

(2018) Lars Larsson et al.   PHYSIOLOGICAL REVIEWS

The CDK inhibitor p21 is a novel target gene of ATF4 and contributes to cell survival under ER stress

(2017) Yasumichi Inoue et al.   FEBS LETTERS

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment

(2017) Nathan B Basisty et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs

(2017) Daria Fijałkowska et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy?

(2016) Nathan Basisty et al.   AGING CELL

Skeletal muscle–specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21–mediated non–cell-autonomous energy metabolism

(2016) Masato Miyake et al.   FASEB JOURNAL

Increased obesity resistance and insulin sensitivity in mice lacking the isocitrate dehydrogenase 2 gene

(2016) Su Jeong Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy

(2016) Mei Li et al.   JOURNAL OF GENERAL PHYSIOLOGY

Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength

(2016) Serge Summermatter et al.   MOLECULAR AND CELLULAR BIOLOGY

Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro

(2016) Giselle A. Joseph et al.   MOLECULAR AND CELLULAR BIOLOGY

The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation

(2016) Jixiu Shan et al.   NUCLEIC ACIDS RESEARCH

Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner

(2015) Shane E. Kruse et al.   AGING CELL

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy

(2015) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response

(2015) Aude De Gassart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The measurement of protein synthesis for assessing proteostasis in studies of slowed aging

(2014) Benjamin F. Miller et al.   AGEING RESEARCH REVIEWS

ATF4 activity: a common feature shared by many kinds of slow-aging mice

(2014) Weiquan Li et al.   AGING CELL

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

(2014) Daniel K. Fox et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Loss of Tropomodulin4 in the zebrafish mutant trage causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

(2014) J. Berger et al.   Disease Models & Mechanisms

Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy

(2014) Ulla Najwa Abdulhag et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

(2014) Michael C. Dyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures

(2013) Brandon H. Toyama et al.   CELL

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

(2013) F. Demontis et al.   Disease Models & Mechanisms

Porcine skeletal muscle differentially expressed gene ATP5B: molecular characterization, expression patterns, and association analysis with meat quality traits

(2013) Haixia Xu et al.   MAMMALIAN GENOME

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice

(2013) Chady H. Hakim et al.   Jove-Journal of Visualized Experiments

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

(2012) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topograph, a Software Platform for Precursor Enrichment Corrected Global Protein Turnover Measurements

(2012) Edward J. Hsieh et al.   MOLECULAR & CELLULAR PROTEOMICS

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

(2011) Steven D. Kunkel et al.   Cell Metabolism

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium

(2010) Angelos K. Sikalidis et al.   AMINO ACIDS

Myoglobin's old and new clothes: from molecular structure to function in living cells

(2010) G. Gros et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The Transcription Factor ATF4 Promotes Skeletal Myofiber Atrophy during Fasting

(2010) Scott M. Ebert et al.   MOLECULAR ENDOCRINOLOGY

Dual Ablation of Grb10 and Grb14 in Mice Reveals Their Combined Role in Regulation of Insulin Signaling and Glucose Homeostasis

(2009) Lowenna J. Holt et al.   MOLECULAR ENDOCRINOLOGY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Genetic Variation in ATP5O Is Associated with Skeletal Muscle ATP50 mRNA Expression and Glucose Uptake in Young Twins

(2009) Tina Rönn et al.   PLoS One

ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

(2008) Suguru Yamaguchi et al.   Cell Metabolism

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE