ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation

(2021) Maxime J. Derisbourg et al.   Nature Communications

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

(2020) Marte Molenaars et al.   Cell Metabolism

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans

(2020) Richard Venz et al.   G3-Genes Genomes Genetics

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

(2019) Jiajun Zhu et al.   Cell Metabolism

TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging

(2019) T. Keith Blackwell et al.   GENETICS

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

(2019) Atsushi Hoshino et al.   NATURE

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

(2019) Jasmina Zivanovic et al.   Cell Metabolism

Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity

(2018) Christopher Hine et al.   ANTIOXIDANTS & REDOX SIGNALING

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H 2 S Production

(2018) Alban Longchamp et al.   CELL

Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan

(2018) Zheng Hu et al.   eLife

Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation inCaenorhabditis elegans

(2017) Warakorn Kulalert et al.   GENETICS

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan

(2017) Nitish Mittal et al.   Nature Communications

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

(2017) Takaaki Akaike et al.   Nature Communications

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

(2017) Yeonwoo Park et al.   Cell Reports

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

(2017) Collin Yvès Ewald et al.   eLife

Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation inCaenorhabditis elegans

(2017) Warakorn Kulalert et al.   GENETICS

Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 inCaenorhabditis elegans

(2016) Amber C. Howard et al.   AGING CELL

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

(2016) John M. Hourihan et al.   MOLECULAR CELL

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

(2016) Caroline Heintz et al.   NATURE

Roles for ROS and hydrogen sulfide in the longevity response to germline loss inCaenorhabditis elegans

(2016) Yuehua Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Bright Fluorescent Probe for H2S Enables Analyte-Responsive, 3D Imaging in Live Zebrafish Using Light Sheet Fluorescence Microscopy

(2015) Matthew D. Hammers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

H 2 S: A Novel Gasotransmitter that Signals by Sulfhydration

(2015) Bindu D. Paul et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

(2015) Michael J Steinbaugh et al.   eLife

Hydrogen Sulfide Levels and Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI)

(2015) K. N. Islam et al.   Journal of the American Heart Association

ATF4 activity: a common feature shared by many kinds of slow-aging mice

(2014) Weiquan Li et al.   AGING CELL

Elevated ATF4 Function in Fibroblasts and Liver of Slow-Aging Mutant Mice

(2014) Weiquan Li et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

(2014) Collin Y. Ewald et al.   NATURE

The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation inCaenorhabditis elegans

(2013) Aris Rousakis et al.   AGING CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The Caenorhabditis elegans Lifespan Machine

(2013) Nicholas Stroustrup et al.   NATURE METHODS

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Contributions of mRNA abundance, ribosome loading, and post- or peri-translational effects to temporal repression of C. elegans heterochronic miRNA targets

(2012) M. Stadler et al.   GENOME RESEARCH

H2S signalling through protein sulfhydration and beyond

(2012) Bindu D. Paul et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

(2011) Aric N. Rogers et al.   Cell Metabolism

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

(2010) Jinling Wang et al.   PLoS Genetics

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS