Review
Biology
Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale
Summary: Age-related muscle wasting, or sarcopenia, is characterized by changes in muscle quality and mitochondrial homeostasis. Mitochondrial dysfunction plays a significant role in the pathogenesis of sarcopenia, and targeting mitochondria may be a potential strategy for preventing and treating this age-related condition.
Review
Immunology
Xingyu Wang, Lan Zhou
Summary: Skeletal muscle is crucial for physical activity, energy metabolism, and temperature maintenance. Muscle stem cells, satellite cells, play a vital role in maintaining homeostasis and promoting muscle regeneration. Intramuscular macrophages, functionally diverse, regulate the quiescence, activation, and differentiation of satellite cells. Aberrant activation of intramuscular macrophages, often triggered by altered muscle microenvironment, disrupts muscle homeostasis and regenerative repair. Manipulating the functional activation of macrophages has potential therapeutic implications for muscle diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura M. de Smalen, Anastasiya Borsch, Aurel B. Leuchtmann, Jonathan F. Gill, Danilo Ritz, Mihaela Zavolan, Christoph Handschin
Summary: Sarcopenia, the age-related loss of skeletal muscle mass and function, can significantly impact quality of life and mortality. This study found that mitochondrial proteostasis plays an important role in muscle aging and highlights the positive effects of exercise on mitochondrial protein synthesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Medicine, Research & Experimental
Colin Harper, Venkatesh Gopalan, Jorming Goh
Summary: This review examines the cellular and molecular changes in skeletal muscle mitochondria during aging, particularly focusing on the efficiency of mitochondrial coupling and its impact on muscle function decline. It also discusses how different exercise modalities can potentially reverse these changes and delay the onset of sarcopenia. Additional concepts such as mitophagy and the implications of muscle fiber type changes with sarcopenia on mitochondrial function are also integrated in this review.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shan-Yan Gao, Yong-Ping Liu, Ri Wen, Xin-Mei Huang, Ping Li, Yu-Hang Yang, Ni Yang, Tie-Ning Zhang
Summary: Uncontrolled diabetes leads to complications in multiple organs, including impaired skeletal muscle and mobility. The expression of Kcnma1 gene, which is involved in myogenesis, decreases in the skeletal muscle of diabetic mice. Knockdown of Kcnma1 in muscle-specific mice results in muscle atrophy and impaired myogenesis, which is more severe in diabetic mice. Further studies reveal that loss of Kcnma1 affects mitochondrial dynamics and biogenesis. In conclusion, Kcnma1 plays a crucial role in maintaining mitochondrial homeostasis and its loss contributes to muscle loss in diabetes.
Article
Cell Biology
Qu Tian, Ann Zenobia Moore, Richard Oppong, Jun Ding, Marta Zampino, Kenneth W. Fishbein, Richard G. Spencer, Luigi Ferrucci
Summary: The study found an association between blood-based estimates of mitochondrial DNA parameters and skeletal muscle bioenergetic capacity, particularly significant in individuals with high heteroplasmy load. Mitochondrial DNA parameters could serve as proxy measures of mitochondrial function in large epidemiological studies, especially for subgroup comparisons.
Article
Cell & Tissue Engineering
Nicole Baker, Steven Wade, Matthew Triolo, John Girgis, Damian Chwastek, Sarah Larrigan, Peter Feige, Ryo Fujita, Colin Crist, Michael A. Rudnicki, Yan Burelle, Mireille Khacho
Summary: Physiological changes in mitochondrial shape play a crucial role in regulating the quiescent state and activation potential of adult stem cells. Mitochondrial fragmentation promotes the exit from deep quiescence, while loss of the mitochondrial fusion protein OPA1 leads to premature activation and depletion of stem cells.
Article
Biochemistry & Molecular Biology
Monika Sztretye, Zoltan Singlar, Nyamkhuu Ganbat, Dana Al-Gaadi, Kitti Szabo, Zoltan Marton Kohler, Laszlo Dux, Aniko Keller-Pinter, Laszlo Csernoch, Peter Szentesi
Summary: The remodelling of the extracellular matrix plays a crucial role in skeletal muscle development and regeneration. The decreased expression of Syndecan-4 leads to reduced muscle performance and altered calcium homeostasis in mice. These effects are observed at both young and aged stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
James Sligar, Danielle A. DeBruin, Nicholas J. Saner, Ashleigh M. Philp, Andrew Philp
Summary: Mitochondria, as the main energy-producing organelles of the cell, play a crucial role in various biological processes in skeletal muscle. Age-related deterioration in skeletal muscle functional capacity is partly driven by a decrease in oxidative capacity and fatigue resistance, which are caused by mitochondrial dysfunction due to alterations in mitochondrial quality control (MQC). Recent research has shown that manipulating MQC may hold great therapeutic potential in preventing mitochondrial dysfunction during aging.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jean-Philippe Leduc-Gaudet, Sabah N. A. Hussain, Esther Barreiro, Gilles Gouspillou
Summary: The maintenance of mitochondrial integrity is crucial for muscle health, with dysfunctional mitochondrial dynamics and mitophagy potentially contributing to sarcopenia. Enhancing mitophagy in skeletal muscle may be a promising therapeutic target to prevent or treat skeletal muscle dysfunction in the elderly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Patrick M. Schaefer, Komal Rathi, Arrienne Butic, Wendy Tan, Katherine Mitchell, Douglas C. Wallace
Summary: Primary mitochondrial diseases are metabolic disorders caused by mutations in mitochondrial and nuclear DNA genes. This study found that endurance exercise may be beneficial for some mitochondrial disorders but not for others. Gene expression analysis identified key pathways involved in the exercise response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Geriatrics & Gerontology
Hui-Jie Zhang, Ben-Hui Wang, Xiang Wang, Chun-Ping Huang, Si-Man Xu, Jia-Li Wang, Tian-E Huang, Wan-Li Xiao, Xiao-Li Tian, Xin-Qiang Lan, Qi-Quan Wang, Yang Xiang
Summary: The study showed that Handelin can protect against muscle atrophy in mice, promote muscle growth, and improve motor function, possibly by maintaining the balance of protein synthesis and degradation and inhibiting inflammation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Cell Biology
Jialin Li, Zhe Wang, Can Li, Yu Song, Yan Wang, Hai Bo, Yong Zhang
Summary: Exercise can prevent muscle aging by regulating mitochondrial homeostasis and antioxidant capacity. Epigenetic changes and mitochondrial dysfunction are the main causes of muscle aging, and exercise can reverse these changes by modulating epigenetic mechanisms.
Article
Biochemistry & Molecular Biology
Denis Vecellio Reane, Cristina Cerqua, Sabrina Sacconi, Leonardo Salviati, Eva Trevisson, Anna Raffaello
Summary: Alternative splicing plays a crucial role in skeletal muscle, both during myogenesis and in post-natal life, by regulating the transcripts of contractile proteins, metabolic enzymes, and transcription factors. Aberrations in alternative splicing can lead to pathological conditions. In addition, many skeletal muscle Ca2+ homeostasis genes are also regulated by alternative splicing mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Yan Wang, Jialin Li, Ziyi Zhang, Runzi Wang, Hai Bo, Yong Zhang
Summary: The mitochondrial unfolded protein response (UPRmt) and mitophagy are two mitochondrial quality control (MQC) systems that work together to maintain mitochondrial homeostasis. This review focuses on the molecular signals regulating their coordination, which is impaired during aging but promoted by exercise. The bidirectional regulation of reactive oxygen species (ROS) and AMPK in modulating this coordination mechanism is also discussed.
Article
Cardiac & Cardiovascular Systems
Hugo E. Verdejo, Elia Becerra, Ricardo Zalaquet, Andrea del Campo, Lorena Garcia, Rodrigo Troncoso, Mario Chiong, Arnaldo Marin, Pablo F. Castro, Sergio Lavandero, Luigi Gabrielli, Ramon Corbalan
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2016)
Review
Cell Biology
Andrea del Campo, Enrique Jaimovich, Maria Florencia Tevy
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2016)
Article
Cardiac & Cardiovascular Systems
Andrea del Campo, Juan Roldan, Hugo E. Verdejo, Ricardo Zalaquett, Elia Becerra, Mario Navarro-Marquez, Rosemarie Mellado, Sergio Lavandero, Ramon Corbalan, Lorena Garcia, Mario Chiong
JOURNAL OF CARDIOLOGY
(2017)
Article
Cell Biology
Andrea del Campo, Ignacio Contreras-Hernandez, Mauricio Castro-Sepulveda, Cristian A. Campos, Reinaldo Figueroa, Maria Florencia Tevy, Veronica Eisner, Mariana Casas, Enrique Jaimovich
Article
Cell Biology
Izela Bernal-Sore, Mario Navarro-Marquez, Cesar Osorio-Fuentealba, Francisco Diaz-Castro, Andrea del Campo, Camila Donoso-Barraza, Omar Porras, Sergio Lavandero, Rodrigo Troncoso
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Andrea del Campo, Catalina Bustos, Carolina Mascayano, Claudio Acuna-Castillo, Rodrigo Troncoso, Leonel E. Rojo
FRONTIERS IN ENDOCRINOLOGY
(2018)
Editorial Material
Physiology
Andrea del Campo
Article
Genetics & Heredity
Celia Medrano, Ana Vega, Rosa Navarrete, M. Jesus Ecay, Rocio Calvo, Samuel Ignacio Pascual, Monica Ruiz-Pons, Laura Toledo, Inmaculada Garcia-Jimenez, Ignacio Arroyo, Andrea Campo, M. Luz Couce, M. Rosario Domingo-Jimenez, M. Teresa Garcia-Silva, Luis Gonzalez-Gutierrez-Solana, Loreto Hierro, Elena Martin-Hernandez, Mercedes Martinez-Pardo, Susana Roldan, Miguel Tomas, Jose C. Cabrera, Francisco Martinez-Bugallo, Lucia Martin-Viota, Isidro Vitoria-Minana, Dirk J. Lefeber, M. Luisa Giros, Mercedes Serrano Gimare, Magdalena Ugarte, Belen Perez, Celia Perez-Cerda
Article
Pharmacology & Pharmacy
Francisco Diaz-Castro, Matias Monsalves-Alvarez, Leonel E. Rojo, Andrea del Campo, Rodrigo Troncoso
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Endocrinology & Metabolism
Clara Quiroga, Georthan Mancilla, Ingrid Oyarzun, Anita Tapia, Mia Caballero, Luigi A. Gabrielli, Denisse Valladares-Ide, Andrea del Campo, Pablo F. Castro, Hugo E. Verdejo
FRONTIERS IN ENDOCRINOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Andrea del Campo, Gonzalo Perez, Pablo F. Castro, Valentina Parra, Hugo E. Verdejo
Summary: Heart failure is a major cause of hospitalization and mortality worldwide. HFpEF predominantly affects the elderly population with overlapping comorbidities, making diagnosis challenging. Despite extensive research, there is still no evidence-based therapy for HFpEF.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Andrea del Campo, Catalina Salamanca, Angelo Fajardo, Francisco Diaz-Castro, Catalina Bustos, Camila Calfio, Rodrigo Troncoso, Edgar R. Pastene-Navarrete, Claudio Acuna-Castillo, Luis A. Milla, Carlos A. Villarroel, Francisco A. Cubillos, Mario Aranda, Leonel E. Rojo
Summary: Anthocyanins from berries have antioxidant and protective effects, preventing weight gain and insulin resistance, but do not influence insulin signaling impairment induced by olanzapine in skeletal muscle cells.
Article
Biochemistry & Molecular Biology
Alejandro Gonzalez-Candia, Alejandro A. Candia, Adolfo Paz, Fuad Mobarec, Rodrigo Urbina-Varela, Andrea del Campo, Emilio A. Herrera, Rodrigo L. Castillo
Summary: This study aims to investigate the response of cardiac function in a rat model to intermittent hypobaric hypoxia (IHH) exposure. The results demonstrate that IHH exposure improves cardiac function and reduces oxidative stress levels.
Review
Geriatrics & Gerontology
Rodrigo Urbina-Varela, Maria Ines Soto-Espinoza, Romina Vargas, Luis Quinones, Andrea del Campo