De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver

Endoplasmic Reticulum Stress Inducer Tunicamycin Alters Hepatic Energy Homeostasis in Mice

(2017) Bin Feng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

(2017) Elisa Álvarez Hernández et al.   JOURNAL OF CLINICAL INVESTIGATION

ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis

(2017) Diane DeZwaan-McCabe et al.   Cell Reports

PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1–Xbp1s pathway expedites liver injury

(2015) Chang Yeob Han et al.   GUT

Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice

(2015) Rana Mroue et al.   PLoS Genetics

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation

(2014) D. Lee Hamilton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC1

(2014) Meilian Liu et al.   Cell Metabolism

Differential Transcriptome Analysis of Diabetes-Resistant and -Sensitive Mouse Islets Reveals Significant Overlap With Human Diabetes Susceptibility Genes

(2014) O. Kluth et al.   DIABETES

Grb10 Deletion Enhances Muscle Cell Proliferation, Differentiation and GLUT4 Plasma Membrane Translocation

(2014) Nancy Mokbel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Central Role for GRB10 in Regulation of Islet Function in Man

(2014) Inga Prokopenko et al.   PLoS Genetics

Identification of Hypoxia-Regulated Genes in the Liver of Common Sole (Solea solea) Fed Different Dietary Lipid Contents

(2013) David Mazurais et al.   MARINE BIOTECHNOLOGY

Hypoxia induces a HIF-1α dependent signaling cascade to make a complex metabolic switch in SGBS-adipocytes

(2013) Andreas Leiherer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Disruption of Growth Factor Receptor-Binding Protein 10 in the Pancreas Enhances  -Cell Proliferation and Protects Mice From Streptozotocin-Induced  -Cell Apoptosis

(2012) J. Zhang et al.   DIABETES

Grb10 regulates the development of fiber number in skeletal muscle

(2012) Lowenna J. Holt et al.   FASEB JOURNAL

Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

(2012) Hyunsun Jo et al.   HEPATOLOGY

Short Term High Fat Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukin-4

(2012) Yewei Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HuR inhibits apoptosis by amplifying Akt signaling through a positive feedback loop

(2012) Mamata Singh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver

(2012) D. Glick et al.   MOLECULAR AND CELLULAR BIOLOGY

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

(2012) Julhash U. Kazi et al.   Molecular Oncology

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Influence of the Hepatic Eukaryotic Initiation Factor 2α (eIF2α) Endoplasmic Reticulum (ER) Stress Response Pathway on Insulin-mediated ER Stress and Hepatic and Peripheral Glucose Metabolism

(2011) Andreas L. Birkenfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3 -Mediated Phosphorylation of Rictor

(2011) C.-H. Chen et al.   Science Signaling

Synergistic hepatotoxicity of N,N-dimethylformamide with carbon tetrachloride in association with endoplasmic reticulum stress

(2010) Tae Hyun Kim et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4

(2010) Qingqiu Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ENDOPLASMIC RETICULUM STRESS INVOLVED IN HEART AND LIVER INJURY IN IRON-LOADED RATS

(2009) Li-Xia Lou et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance

(2009) R. Ye et al.   DIABETES

Pioglitazone Reduces ER Stress in the Liver: Direct Monitoring of in vivo ER Stress Using ER Stress-activated Indicator Transgenic Mice

(2009) Kazutomi YOSHIUCHI et al.   ENDOCRINE JOURNAL

Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells

(2009) Do-Sung Kim et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysregulation of unfolded protein response partially underlies proapoptotic activity of bortezomib in multiple myeloma cells

(2009) Hongjuan Dong et al.   LEUKEMIA & LYMPHOMA

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization

(2008) Giada Monami et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

(2008) Tsuguhito Ota et al.   JOURNAL OF CLINICAL INVESTIGATION