Permeability of Metformin across an In Vitro Blood–Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs)

Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands

(2023) Siavash Shahbazi Nia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Blood–Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke

(2022) Kelsy L. Nilles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differences in Cerebral Distribution between Imipramine and Paroxetine via Membrane Transporters at the Rat Blood-Brain Barrier

(2022) Shin-ichi Akanuma et al.   PHARMACEUTICAL RESEARCH

Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective

(2022) Sabrina Rahman Archie et al.   NEUROTOXICOLOGY

In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals

(2022) Saeideh Nozohouri et al.   PHARMACEUTICAL RESEARCH

Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke

(2022) Clara Bourget et al.   Journal of Neuroinflammation

Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping

(2022) Yong Zhang et al.   Fluids and Barriers of the CNS

Dental Pulp-Derived Stem Cells Preserve Astrocyte Health During Induced Gliosis by Modulating Mitochondrial Activity and Functions

(2022) Derek Barthels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeting organic cation transporters at the blood-brain barrier to treat ischemic stroke in rats

(2022) Joshua A. Stanton et al.   EXPERIMENTAL NEUROLOGY

Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3

(2022) Lukas Gebauer et al.   Biomolecules

Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome

(2022) Ali Ehsan Sifat et al.   Fluids and Barriers of the CNS

Structural basis of organic cation transporter-3 inhibition

(2022) Basavraj Khanppnavar et al.   Nature Communications

Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke

(2021) Sejal Sharma et al.   LIFE SCIENCES

Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing

(2021) Hermann Koepsell   Expert Opinion on Drug Metabolism & Toxicology

Ion Channels and Electrophysiological Properties of Astrocytes: Implications for Emergent Stimulation Technologies

(2021) Jessica McNeill et al.   Frontiers in Cellular Neuroscience

Evaluation of the Effectiveness of Post-Stroke Metformin Treatment Using Permanent Middle Cerebral Artery Occlusion in Rats

(2021) Gintare Zemgulyte et al.   Pharmaceuticals

Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability

(2021) Md. Shafikur Rahman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers

(2021) Hossam Kadry et al.   Fluids and Barriers of the CNS

Glutamate Buffering Capacity and Blood-Brain Barrier Protection of Opioid Receptor Agonists Biphalin and Nociceptin

(2021) Saeideh Nozohouri et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Novel approaches for the delivery of therapeutics in ischemic stroke

(2020) Saeideh Nozohouri et al.   DRUG DISCOVERY TODAY

Transporter-Mediated Delivery of Small Molecule Drugs to the Brain: A Critical Mechanism That Can Advance Therapeutic Development for Ischemic Stroke

(2020) Erica I. Williams et al.   Pharmaceutics

Metformin and Its Benefits for Various Diseases

(2020) Ziquan Lv et al.   Frontiers in Endocrinology

Signature-based approaches for informed drug repurposing: targeting CNS disorders

(2020) Rammohan Shukla et al.   NEUROPSYCHOPHARMACOLOGY

Differences in metformin and thiamine uptake between human and mouse organic cation transporter OCT1: structural determinants and potential consequences for intrahepatic concentrations

(2020) Marleen J. Meyer et al.   DRUG METABOLISM AND DISPOSITION

Blood-Brain Barrier Damage in Ischemic Stroke and Its Regulation by Endothelial Mechanotransduction

(2020) Keqing Nian et al.   Frontiers in Physiology

The progress of neuronal autophagy in cerebral ischemia stroke: Mechanisms, roles and research methods

(2019) Kai Hou et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein

(2019) Rikiya Ohashi et al.   MOLECULAR PHARMACEUTICS

Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP)

(2019) Thamer H Albekairi et al.   Pharmaceutics

Neuroprotective effect of metformin on dopaminergic neurodegeneration and α-synuclein aggregation in C. elegans model of Parkinson’s disease

(2019) Nada Saewanee et al.   NEUROSCIENCE RESEARCH

Region-specific blood–brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease

(2019) Gayathri Nair Sekhar et al.   Fluids and Barriers of the CNS

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

(2018) Carola Rotermund et al.   Frontiers in Endocrinology

Neurovascular unit transport responses to ischemia and common coexisting conditions: smoking and diabetes

(2018) Ali E Sifat et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

(2018) Ligen Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metformin — a new old drug

(2017) Marta Patrycja Wróbel et al.   Endokrynologia Polska

Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells

(2017) Toshiki Kurosawa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Metformin – a Future Therapy for Neurodegenerative Diseases

(2017) Magdalena Markowicz-Piasecka et al.   PHARMACEUTICAL RESEARCH

Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

(2017) Shikha Prasad et al.   Redox Biology

Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?

(2017) Mohammad A. Kaisar et al.   Redox Biology

Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB)

(2017) Gayathri N. Sekhar et al.   PLoS One

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery

(2016) Travis T. Wager et al.   ACS Chemical Neuroscience

In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment

(2015) Li Yang et al.   BRAIN RESEARCH

Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood-brain barrier and its implications to the transport of neurotoxins

(2015) Kuo-Chen Wu et al.   JOURNAL OF NEUROCHEMISTRY

Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates

(2015) Kristina Hacker et al.   PLoS One

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

(2013) K L R Brouwer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Molecular mechanism of histamine clearance by primary human astrocytes

(2013) Takeo Yoshikawa et al.   GLIA

Metformin: an old but still the best treatment for type 2 diabetes

(2013) Lilian Beatriz Aguayo Rojas et al.   Diabetology & Metabolic Syndrome

Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats

(2013) Xinjuan Li et al.   Neuroscience Bulletin

P-Glycoprotein Function at the Blood–Brain Barrier: Effects of Age and Gender

(2012) Daniëlle M. E. van Assema et al.   MOLECULAR IMAGING AND BIOLOGY

Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells

(2011) Asuka Horie et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Baicalin reduces the permeability of the blood–brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells

(2011) Haiyan Zhu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents

(2010) Chun-Jung Lin et al.   JOURNAL OF NEUROCHEMISTRY

The Na–K–Cl Co-transporter in astrocyte swelling

(2010) Arumugam R. Jayakumar et al.   METABOLIC BRAIN DISEASE

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

(2009) Anne T. Nies et al.   HEPATOLOGY

Strategies to assess blood–brain barrier penetration

(2008) Li Di et al.   Expert Opinion on Drug Discovery

Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney

(2008) Zoulikha M Zaïr et al.   PHARMACOGENOMICS