Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability

Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model

(2021) Abraham J. Al‐Ahmad et al.   JOURNAL OF NEUROENDOCRINOLOGY

Trends in peptide drug discovery

(2021) Markus Muttenthaler et al.   NATURE REVIEWS DRUG DISCOVERY

Identification and characterization of two structurally related dipeptides that enhance catalytic efficiency of neurolysin

(2021) Srinidhi Jayaraman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Amide Bond Bioisosteres: Strategies, Synthesis, and Successes

(2020) Shikha Kumari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Catherine Owens Johnson et al.   LANCET NEUROLOGY

Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice

(2019) Srinidhi Jayaraman et al.   JOURNAL OF NEUROCHEMISTRY

Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders

(2019) Vardan T. Karamyan   MEDICAL HYPOTHESES

Metabolism of Peptide Drugs and Strategies to Improve their Metabolic Stability

(2018) Jin-Feng Yao et al.   CURRENT DRUG METABOLISM

Lipophilic Efficiency as an Important Metric in Drug Design

(2018) Ted W. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin

(2018) Pedro F. Teixeira et al.   JOURNAL OF MOLECULAR BIOLOGY

Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)

(2017) Nihar Kinarivala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore elucidation of phosphoiodyn A – Potent and selective peroxisome proliferator-activated receptor β/δ agonists with neuroprotective activity

(2016) Nihar Kinarivala et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Allosteric Potentiation of Peptidase Neurolysin by Small Molecules

(2016) Srinidhi Jayaraman et al.   BIOPHYSICAL JOURNAL

BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice

(2016) Ning Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Executive Summary: Heart Disease and Stroke Statistics—2016 Update

(2016) Dariush Mozaffarian et al.   CIRCULATION

Selecting Good ‘Drug-Like’ Properties to Optimize Small Molecule Blood-Brain Barrier Penetration

(2016) Paul C. Trippier   CURRENT MEDICINAL CHEMISTRY

6-Methoxy-indanone derivatives as potential probes for β-amyloid plaques in Alzheimer's disease

(2016) Dou-Dou Nan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Preparation and preliminary characterization of recombinant neurolysin for in vivo studies

(2016) Naomi J. Wangler et al.   JOURNAL OF BIOTECHNOLOGY

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

DEPBT as Coupling Reagent To Avoid Racemization in a Solution-Phase Synthesis of a Kyotorphin Derivative

(2014) Montserrat Heras et al.   SYNTHESIS-STUTTGART

Immobilized Coupling Reagents: Synthesis of Amides/Peptides

(2014) Prabhakar Cherkupally et al.   ACS Combinatorial Science

Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain

(2013) Mamoon Rashid et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of nociceptive responses after systemic administration of amidated kyotorphin

(2011) MMB Ribeiro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Peptide Coupling Reagents, More than a Letter Soup

(2011) Ayman El-Faham et al.   CHEMICAL REVIEWS

Targeted Catalytic Inactivation of Angiotensin Converting Enzyme by Lisinopril-Coupled Transition-Metal Chelates

(2011) Jeff C. Joyner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Permeability of Endothelial and Astrocyte Cocultures: In Vitro Blood–Brain Barrier Models for Drug Delivery Studies

(2010) Guanglei Li et al.   ANNALS OF BIOMEDICAL ENGINEERING

Association of the Novel Non-AT1, Non-AT2 Angiotensin Binding Site with Neuronal Cell Death

(2010) M. Rashid et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Purity, cell viability, expression of GFAP and bystin in astrocytes cultured by different procedures

(2009) Fang Du et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid

(2007) James Scott Miners et al.   JOURNAL OF NEUROSCIENCE METHODS