In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals

Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model

(2021) Abraham J. Al‐Ahmad et al.   JOURNAL OF NEUROENDOCRINOLOGY

Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability

(2021) Md. Shafikur Rahman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification and characterization of two structurally related dipeptides that enhance catalytic efficiency of neurolysin

(2021) Srinidhi Jayaraman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Novel approaches for the delivery of therapeutics in ischemic stroke

(2020) Saeideh Nozohouri et al.   DRUG DISCOVERY TODAY

The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier

(2020) William M. Pardridge   Frontiers in Physiology

Challenging the Ischemic Core Concept in Acute Ischemic Stroke Imaging

(2020) Mayank Goyal et al.   STROKE

Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein

(2019) Rikiya Ohashi et al.   MOLECULAR PHARMACEUTICS

Stroke Treatment Academic Industry Roundtable X

(2019) Sean I. Savitz et al.   STROKE

Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice

(2019) Srinidhi Jayaraman et al.   JOURNAL OF NEUROCHEMISTRY

Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders

(2019) Vardan T. Karamyan   MEDICAL HYPOTHESES

Neurolysin: From Initial Detection to Latest Advances

(2018) Frédéric Checler et al.   NEUROCHEMICAL RESEARCH

Combining Neuroprotection With Endovascular Treatment of Acute Stroke

(2017) Michael Tymianski   STROKE

In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment

(2015) Li Yang et al.   BRAIN RESEARCH

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

(2013) K L R Brouwer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain

(2013) Mamoon Rashid et al.   JOURNAL OF NEUROCHEMISTRY

Opioid receptor agonists reduce brain edema in stroke

(2011) Li Yang et al.   BRAIN RESEARCH

Identification of Membrane-bound Variant of Metalloendopeptidase Neurolysin (EC 3.4.24.16) as the Non-angiotensin Type 1 (Non-AT1), Non-AT2Angiotensin Binding Site

(2011) Naomi J. Wangler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of the Novel Non-AT1, Non-AT2 Angiotensin Binding Site with Neuronal Cell Death

(2010) M. Rashid et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System

(2009) M. Friden et al.   DRUG METABOLISM AND DISPOSITION

Molecular imaging of cell death

(2009) Marijke De Saint-Hubert et al.   METHODS