Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection

Evasion of cGAS and TRIM5 defines pandemic HIV

(2022) Lorena Zuliani-Alvarez et al.   Nature Microbiology

Modeling human adaptive immune responses with tonsil organoids

(2021) Lisa E. Wagar et al.   NATURE MEDICINE

Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity

(2021) Lise Chauveau et al.   EMBO REPORTS

Self-guarding of MORC3 enables virulence factor-triggered immunity

(2021) Moritz M. Gaidt et al.   NATURE

CTL Clonotypes with Higher TCR Affinity Have Better Ability to Reduce the HIV Latent Reservoir

(2020) Noemia S. Lima et al.   JOURNAL OF IMMUNOLOGY

The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8+ T-cell responses in vitro

(2020) Laura Papagno et al.   Scientific Reports

New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses

(2020) Alice Gutjahr et al.   EBioMedicine

Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways

(2020) Candice Mazewski et al.   Frontiers in Immunology

STING agonists activate latently infected cells and enhance SIV-specific responses ex vivo in naturally SIV controlled cynomolgus macaques

(2019) Takuya Yamamoto et al.   Scientific Reports

Pathogenic Role of Type I Interferons in HIV-Induced Immune Impairments in Humanized Mice

(2019) Lishan Su   Current HIV/AIDS Reports

Priming of HIV-1-specific CD8+ T cells with strong functional properties from naïve T cells

(2019) Nozomi Kuse et al.   EBioMedicine

HIV-2 as a model to identify a functional HIV cure

(2019) Joakim Esbjörnsson et al.   AIDS Research and Therapy

Aiming for protective T-cell responses: a focus on the first generation conserved-region HIVconsv vaccines in preventive and therapeutic clinical trials

(2019) Tomáš Hanke   Expert Review of Vaccines

Immune Responses to Retroviruses

(2018) Asier Sáez-Cirión et al.   Annual Review of Immunology

Interferon-associated therapies toward HIV control: The back and forth

(2018) Nicolas Noël et al.   CYTOKINE & GROWTH FACTOR REVIEWS

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways

(2018) Shuliang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

(2018) Xavier Lahaye et al.   CELL

SAMHD1 acts at stalled replication forks to prevent interferon induction

(2018) Flavie Coquel et al.   NATURE

Interferon Alpha Enhances NK Cell Function and the Suppressive Capacity of HIV-Specific CD8+ T Cells

(2018) Abena K. R. Kwaa et al.   JOURNAL OF VIROLOGY

Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study

(2018) Joakim Esbjörnsson et al.   Lancet HIV

Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses

(2017) Alice Gutjahr et al.   JOURNAL OF IMMUNOLOGY

HIV-2 infection is associated with preserved GALT homeostasis and epithelial integrity despite ongoing mucosal viral replication

(2017) S M Fernandes et al.   Mucosal Immunology

Delayed differentiation of potent effector CD8 + T cells reducing viremia and reservoir seeding in acute HIV infection

(2017) Hiroshi Takata et al.   Science Translational Medicine

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+T Cells in HIV-2–Infected Controllers

(2016) Mathieu Angin et al.   JOURNAL OF IMMUNOLOGY

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1

(2016) Jonathan Maelfait et al.   Cell Reports

Reduced naïve CD8+T-cell priming efficacy in elderly adults

(2015) Olivia Briceño et al.   AGING CELL

How does the humoral response to HIV-2 infection differ from HIV-1 and can this explain the distinct natural history of infection with these two human retroviruses?

(2015) Shokouh Makvandi-Nejad et al.   IMMUNOLOGY LETTERS

Priming of Qualitatively Superior Human Effector CD8+T Cells Using TLR8 Ligand Combined with FLT3 Ligand

(2015) Anna Lissina et al.   JOURNAL OF IMMUNOLOGY

Viruses transfer the antiviral second messenger cGAMP between cells

(2015) A. Bridgeman et al.   SCIENCE

Transmission of innate immune signaling by packaging of cGAMP in viral particles

(2015) Matteo Gentili et al.   SCIENCE

A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control

(2015) Gang Xin et al.   Cell Reports

Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers

(2015) Enrique Martin-Gayo et al.   PLoS Pathogens

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

(2015) Cécile Alanio et al.   eLife

Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy

(2015) Steven E. Bosinger et al.   Current HIV/AIDS Reports

Type I Interferon Signaling Enhances CD8+ T Cell Effector Function and Differentiation during Murine Gammaherpesvirus 68 Infection

(2014) R. N. Jennings et al.   JOURNAL OF VIROLOGY

Correlates of T-cell-mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection

(2013) T. I. de Silva et al.   BLOOD

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection

(2013) Myoungjoo V. Kim et al.   IMMUNITY

CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells

(2013) Stefano Berre et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis

(2013) Samuel Nyamweya et al.   REVIEWS IN MEDICAL VIROLOGY

Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection

(2012) L. Trautmann et al.   BLOOD

HIV and HLA Class I: An Evolving Relationship

(2012) Philip J.R. Goulder et al.   IMMUNITY

BAG6/BAT3: emerging roles in quality control for nascent polypeptides

(2012) H. Kawahara et al.   JOURNAL OF BIOCHEMISTRY

Cutting Edge: Generation of Memory Precursors and Functional Memory CD8+ T Cells Depends on T Cell Factor-1 and Lymphoid Enhancer-Binding Factor-1

(2012) X. Zhou et al.   JOURNAL OF IMMUNOLOGY

Long-term nonprogressors and elite controllers in the ANRS CO5 HIV-2 cohort

(2011) Rodolphe Thiébaut et al.   AIDS

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

(2011) A. R. Hersperger et al.   BLOOD

HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells

(2011) D. Favre et al.   BLOOD

Type I Interferon Contributes to CD4+ T Cell Depletion Induced by Infection with HIV-1 in the Human Thymus

(2011) V. Sivaraman et al.   JOURNAL OF VIROLOGY

Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection

(2010) Aleksandra Leligdowicz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

(2010) Nicolas Manel et al.   NATURE

Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village

(2010) Maarten van der Loeff et al.   Retrovirology

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

(2009) J. R. Almeida et al.   BLOOD

Common Genetic Variation and the Control of HIV-1 in Humans

(2009) Jacques Fellay et al.   PLoS Genetics

Polyfunctional T cell responses are a hallmark of HIV-2 infection

(2008) Melody G. Duvall et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control

(2008) Stephen A. Migueles et al.   IMMUNITY

CD8+ T cell efficacy in vaccination and disease

(2008) Victor Appay et al.   NATURE MEDICINE