Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis

Origins of HIV and the AIDS Pandemic

(2013) P. M. Sharp et al.   Cold Spring Harbor Perspectives in Medicine

PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia

(2012) Rita Tendeiro et al.   AIDS

Novel agents for the treatment of HIV-2 infection

(2012) Kevin Peterson et al.   ANTIVIRAL THERAPY

HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1

(2012) Jinwoo Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4+ T Cell Counts in Viremic HIV-2 Infection

(2012) M. Khalid et al.   JOURNAL OF VIROLOGY

Inhibition of HIV-1 Disease Progression by Contemporaneous HIV-2 Infection

(2012) Joakim Esbjörnsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Are Plasma Biomarkers of Immune Activation Predictive of HIV Progression: A Longitudinal Comparison and Analyses in HIV-1 and HIV-2 Infections?

(2012) Samuel Nyamweya et al.   PLoS One

HIV Interplay with SAMHD1

(2012) T. Schaller et al.   SCIENCE

Mortality and immunovirological outcomes on antiretroviral therapy in HIV-1 and HIV-2-infected individuals in the Gambia

(2011) Ingrid Peterson et al.   AIDS

Update on Human Immunodeficiency Virus (HIV)-2 Infection

(2011) O. T. Campbell-Yesufu et al.   CLINICAL INFECTIOUS DISEASES

Broad and Potent Neutralizing Antibody Responses Elicited in Natural HIV-2 Infection

(2011) R. Kong et al.   JOURNAL OF VIROLOGY

Potent Intratype Neutralizing Activity Distinguishes Human Immunodeficiency Virus Type 2 (HIV-2) from HIV-1

(2011) G. Ozkaya Sahin et al.   JOURNAL OF VIROLOGY

Potent Autologous and Heterologous Neutralizing Antibody Responses Occur in HIV-2 Infection across a Broad Range of Infection Outcomes

(2011) T. I. de Silva et al.   JOURNAL OF VIROLOGY

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Analysis of lymphocyte cell death and apoptosis in HIV-2-infected patients

(2010) A. C. JALECO et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection

(2010) Aleksandra Leligdowicz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microbial Translocation Correlates with the Severity of Both HIV‐1 and HIV‐2 Infections

(2010) Salma Nowroozalizadeh et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-2 Genetic Evolution in Patients with Advanced Disease Is Faster than That in Matched HIV-1 Patients

(2010) H. Skar et al.   JOURNAL OF VIROLOGY

Cell-Associated Viral Burden Provides Evidence of Ongoing Viral Replication in Aviremic HIV-2-Infected Patients

(2010) R. S. Soares et al.   JOURNAL OF VIROLOGY

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

(2010) Nicolas Manel et al.   NATURE

Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village

(2010) Maarten van der Loeff et al.   Retrovirology

Cause of death among people with retroviral infection in rural Guinea-Bissau

(2010) Maxwell Cooper et al.   TROPICAL DOCTOR

HIV-2 capsids distinguish high and low virus load patients in a West African community cohort

(2010) Clayton O. Onyango et al.   VACCINE

Differences in proviral DNA load between HIV-1- and HIV-2-infected patients

(2009) Marie Gueudin et al.   AIDS

Changes in prevalence and incidence of HIV-1, HIV-2 and dual infections in urban areas of Bissau, Guinea-Bissau: is HIV-2 disappearing?

(2009) Zacarias J da Silva et al.   AIDS

Studies on toll-like receptor stimuli responsiveness in HIV-1 and HIV-2 infections

(2009) Salma Nowroozalizadeh et al.   CYTOKINE

Assessment of mother-to-child HIV-1 and HIV-2 transmission: an AIDS reference laboratory collaborative study

(2009) E Pádua et al.   HIV MEDICINE

Direct Relationship between Virus Load and Systemic Immune Activation in HIV‐2 Infection

(2009) Aleksandra Leligdowicz et al.   JOURNAL OF INFECTIOUS DISEASES

Downregulation of the T-Cell Receptor by Human Immunodeficiency Virus Type 2 Nef Does Not Protect against Disease Progression

(2009) J. Feldmann et al.   JOURNAL OF VIROLOGY

Antagonism to and Intracellular Sequestration of Human Tetherin by the Human Immunodeficiency Virus Type 2 Envelope Glycoprotein

(2009) A. Le Tortorec et al.   JOURNAL OF VIROLOGY

Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2

(2009) Bin Jia et al.   PLoS Pathogens

Comprehensive analysis of HIV Gag-specific IFN-γ response in HIV-1- and HIV-2-infected asymptomatic patients from a clinical cohort in The Gambia

(2008) Beatrice O. Ondondo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Polyfunctional T cell responses are a hallmark of HIV-2 infection

(2008) Melody G. Duvall et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gag-Specific CD4+ T-Cell Frequency Is Inversely Correlated with Proviral Load and Directly Correlated with Immune Activation in Infection with Human Immunodeficiency Virus Type 2 (HIV-2) but Not HIV-1

(2008) R. B. Foxall et al.   JOURNAL OF VIROLOGY