HIV-2 as a model to identify a functional HIV cure

Key Viral Adaptations Preceding the AIDS Pandemic

(2019) Daniel Sauter et al.   Cell Host & Microbe

Low Postseroconversion CD4+ T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection

(2019) Angelica A. Palm et al.   mBio

Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein–Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2–Infected Individuals

(2019) Ingrid Karlsson et al.   JOURNAL OF INFECTIOUS DISEASES

T and B-cell perturbations are similar in ART-naïve HIV-1 and HIV-1/2 dually infected patients

(2019) Bo L. Hønge et al.   AIDS

T and B-cell perturbations identify distinct differences in HIV-2 compared with HIV-1 induced immunodeficiency

(2019) Bo L. Hønge et al.   AIDS

HTLV prevalence is no longer following the decreasing HIV prevalence – 20 years of retroviral surveillance in Guinea-Bissau, West Africa

(2019) Mads Mose Jensen et al.   ACTA TROPICA

Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection

(2019) Assia Samri et al.   PLoS Pathogens

New insights are game-changers in HIV-2 disease management – Authors' reply

(2019) Joakim Esbjörnsson et al.   Lancet HIV

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

(2019) Alexandra M. Bender et al.   Cell Host & Microbe

Performance of Bio-Rad HIV-1/2 Confirmatory Assay in HIV-1, HIV-2 and HIV-1/2 dually reactive patients - comparison with INNO-LIA and immunocomb discriminatory assays

(2019) Jacob Lindman et al.   JOURNAL OF VIROLOGICAL METHODS

Discriminatory rapid tests cause HIV-type misclassification—evaluation of three rapid tests using clinical samples from Guinea-Bissau

(2019) Bo Langhoff Hønge et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

(2019) Prasanta K. Dash et al.   Nature Communications

The influence of human leukocyte antigen-types on disease progression among HIV-2 infected patients in Guinea-Bissau

(2018) Ditte Thomsen et al.   AIDS

HIV-2 continues to decrease, whereas HIV-1 is stabilizing in Guinea-Bissau

(2018) Jens S. Olesen et al.   AIDS

The challenge of discriminating between HIV-1, HIV-2 and HIV-1/2 dual infections

(2018) BL Hønge et al.   HIV MEDICINE

Targeting the Latent Reservoir for HIV-1

(2018) Srona Sengupta et al.   IMMUNITY

Soluble Macrophage Mannose Receptor (sCD206/sMR) as a Biomarker in Human Immunodeficiency Virus Infection

(2018) Morten N Andersen et al.   JOURNAL OF INFECTIOUS DISEASES

Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea-Bissau: a cross-sectional study

(2018) Helene L. Grønborg et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Barriers and strategies to achieve a cure for HIV

(2018) Matthew C Pitman et al.   Lancet HIV

Long-term Persistent Elite HIV-controllers: The Right Model of Functional Cure

(2018) Laura Tarancon-Diez et al.   EBioMedicine

Protease Inhibitors or NNRTIs as First-Line HIV-1 Treatment in West Africa (PIONA)

(2018) Sanne Jespersen et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

(2018) Pilar Mendoza et al.   NATURE

Low-Bias RNA Sequencing of the HIV-2 Genome from Blood Plasma

(2018) Katherine L. James et al.   JOURNAL OF VIROLOGY

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

(2018) Erica N. Borducchi et al.   NATURE

Prevalence of HIV-1 pretreatment drug resistance among treatment naïve pregnant women in Bissau, Guinea Bissau

(2018) Sten Wilhelmson et al.   PLoS One

Cross Type Neutralizing Antibodies Detected in a Unique HIV-2 Infected Individual From India

(2018) K. K. Vidyavijayan et al.   Frontiers in Immunology

Is it time to revise the notion that HIV-2 is benign?

(2018) Christian Wejse et al.   Lancet HIV

Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study

(2018) Joakim Esbjörnsson et al.   Lancet HIV

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

(2017) Ling Xu et al.   SCIENCE

A humanized mouse model for HIV-2 infection and efficacy testing of a single-pill triple-drug combination anti-retroviral therapy

(2017) Shuang Hu et al.   VIROLOGY

Peripheral T follicular helper Cells Make a Difference in HIV Reservoir Size between Elite Controllers and Patients on Successful cART

(2017) Marcial García et al.   Scientific Reports

Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections

(2016) Susanna M. Bächle et al.   AIDS

CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection

(2016) Marcus Buggert et al.   AIDS

Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1–Infected Individuals from Guinea-Bissau and Denmark

(2016) Marie Borggren et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Assessing factors for loss to follow-up of HIV infected patients in Guinea-Bissau

(2016) Pernille Bejer Nordentoft et al.   INFECTION

Brief Report

(2016) Bo L. Hønge et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+T Cells in HIV-2–Infected Controllers

(2016) Mathieu Angin et al.   JOURNAL OF IMMUNOLOGY

Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research

(2016) Paul W. Denton et al.   Journal of Translational Medicine

Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

(2016) Erica N. Borducchi et al.   NATURE

Diabetes mellitus and impaired fasting glucose in ART-naïve patients with HIV-1, HIV-2 and HIV-1/2 dual infection in Guinea-Bissau: a cross-sectional study

(2016) Ditte Steiniche et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Reversal of Latency as Part of a Cure for HIV-1

(2016) Thomas Aagaard Rasmussen et al.   TRENDS IN MICROBIOLOGY

Mortality and survival patterns of people living with HIV-2

(2016) Boris Tchounga et al.   Current Opinion in HIV and AIDS

Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation

(2016) Trevor A Crowell et al.   Journal of the International AIDS Society

Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau

(2016) Allan Sørensen et al.   Infectious Diseases

HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report

(2016) Pierre Frange et al.   Lancet HIV

HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART

(2016) Jintanat Ananworanich et al.   EBioMedicine

Cocirculation of Several Similar But Unique HIV-1 Recombinant Forms in Guinea-Bissau Revealed by Near Full-Length Genomic Sequencing

(2015) Angelica A. Palm et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Comment on Gautheret-Dejeanet al.: Performance of rapid tests for discrimination between HIV-1 and/or HIV-2 infections

(2015) Bo Langhoff Hønge et al.   JOURNAL OF MEDICAL VIROLOGY

Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child

(2015) Katherine Luzuriaga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential effects of sex in a West African cohort of HIV-1, HIV-2 and HIV-1/2 dually infected patients: men are worse off

(2015) Sanne Jespersen et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

High level of HIV-1 drug resistance among patients with HIV-1 and HIV-1/2 dual infections in Guinea-Bissau

(2015) Sanne Jespersen et al.   Virology Journal

Lack of awareness of treatment failure among HIV-1-infected patients in Guinea-Bissau - a retrospective cohort study

(2015) Sanne Jespersen et al.   Journal of the International AIDS Society

Effect of HIV-2 infection on HIV-1 disease progression and mortality

(2014) Joakim Esbjörnsson et al.   AIDS

Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation

(2014) Timothy J. Henrich et al.   ANNALS OF INTERNAL MEDICINE

Challenges facing HIV treatment in Guinea-Bissau: the benefits of international research collaborations

(2014) Sanne Jespersen et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Cohort Profile: The Bissau HIV Cohort—a cohort of HIV-1, HIV-2 and co-infected patients

(2014) Sanne Jespersen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Hepatitis C prevalence among HIV-infected patients in Guinea-Bissau: a descriptive cross-sectional study

(2014) Bo Langhoff Hønge et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Thymic HIV-2 Infection Uncovers Posttranscriptional Control of Viral Replication in Human Thymocytes

(2014) Helena Nunes-Cabaço et al.   JOURNAL OF VIROLOGY

Hepatitis B and Delta Virus Are Prevalent but Often Subclinical Co-Infections among HIV Infected Patients in Guinea-Bissau, West Africa: A Cross-Sectional Study

(2014) Bo Langhoff Hønge et al.   PLoS One

Mortality rates in people dually infected with HIV-1/2 and those infected with either HIV-1 or HIV-2

(2013) Puck D. Prince et al.   AIDS

Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals

(2013) Joakim Esbjörnsson et al.   AIDS

Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau

(2013) Victor Raúl Gómez Román et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Barriers and facilitators to antiretroviral therapy adherence among patients with HIV in Bissau, Guinea-Bissau: A qualitative study

(2013) Dlama N Rasmussen et al.   AJAR-African Journal of AIDS Research

Correlates of T-cell-mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection

(2013) T. I. de Silva et al.   BLOOD

Impact of tuberculosis treatment on CD4 cell count, HIV RNA, and p24 antigen in patients with HIV and tuberculosis

(2013) C. Wejse et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Performance of 3 Rapid Tests for Discrimination Between HIV-1 and HIV-2 in Guinea-Bissau, West Africa

(2013) Bo Langhoff Hønge et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Faster Progression to AIDS and AIDS-Related Death Among Seroincident Individuals Infected With Recombinant HIV-1 A3/CRF02_AG Compared With Sub-subtype A3

(2013) Angelica A. Palm et al.   JOURNAL OF INFECTIOUS DISEASES

Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis

(2013) Samuel Nyamweya et al.   REVIEWS IN MEDICAL VIROLOGY

Declining Prevalence Rates of Syphilis Among Police Officers in Guinea-Bissau, West Africa, 1990–2010

(2013) Jacob Lopatko Lindman et al.   SEXUALLY TRANSMITTED DISEASES

Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study

(2013) Bo Langhoff Hønge et al.   BMJ Open

Frequent Intratype Neutralization by Plasma Immunoglobulin A Identified in HIV Type 2 Infection

(2012) Gülşen Özkaya Şahin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Effect of Complement on HIV-2 Plasma Antiviral Activity Is Intratype Specific and Potent

(2012) G. Ozkaya Sahin et al.   JOURNAL OF VIROLOGY

Shock and kill

(2012) Steven G. Deeks   NATURE

Inhibition of HIV-1 Disease Progression by Contemporaneous HIV-2 Infection

(2012) Joakim Esbjörnsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phenotypic and genetic characterisation of bacterial sexually transmitted infections in Bissau, Guinea-Bissau, West Africa: a prospective cohort study

(2012) Birgitta Olsen et al.   BMJ Open

Assessment of simple risk markers for early mortality among HIV-infected patients in Guinea-Bissau: a cohort study

(2012) Inés Oliveira et al.   BMJ Open

The Use of Nonhuman Primate Models of HIV Infection for the Evaluation of Antiviral Strategies

(2011) Koen K.A. Van Rompay   AIDS RESEARCH AND HUMAN RETROVIRUSES

Broad and Potent Neutralizing Antibody Responses Elicited in Natural HIV-2 Infection

(2011) R. Kong et al.   JOURNAL OF VIROLOGY

Potent Intratype Neutralizing Activity Distinguishes Human Immunodeficiency Virus Type 2 (HIV-2) from HIV-1

(2011) G. Ozkaya Sahin et al.   JOURNAL OF VIROLOGY

Potent Autologous and Heterologous Neutralizing Antibody Responses Occur in HIV-2 Infection across a Broad Range of Infection Outcomes

(2011) T. I. de Silva et al.   JOURNAL OF VIROLOGY

HIV-1 Molecular Epidemiology in Guinea-Bissau, West Africa: Origin, Demography and Migrations

(2011) Joakim Esbjörnsson et al.   PLoS One

Elite controllers as a model of functional cure

(2011) Brigitte Autran et al.   Current Opinion in HIV and AIDS

Human exposure to persistent organic pollutants in West Africa — A temporal trend study from Guinea-Bissau

(2010) Linda Linderholm et al.   ENVIRONMENT INTERNATIONAL

Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection

(2010) Aleksandra Leligdowicz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Higher mortality in HIV-2/HTLV-1 co-infected patients with pulmonary tuberculosis in Guinea-Bissau, West Africa, compared to HIV-2-positive HTLV-1-negative patients

(2010) Hans Norrgren et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Long-term Nonprogressive Disease Among Untreated HIV-Infected Individuals

(2010) Stephen A. Migueles et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Microbial Translocation Correlates with the Severity of Both HIV‐1 and HIV‐2 Infections

(2010) Salma Nowroozalizadeh et al.   JOURNAL OF INFECTIOUS DISEASES

Cell-Associated Viral Burden Provides Evidence of Ongoing Viral Replication in Aviremic HIV-2-Infected Patients

(2010) R. S. Soares et al.   JOURNAL OF VIROLOGY

Influence of HLA Class I and HLA-KIR Compound Genotypes on HIV-2 Infection and Markers of Disease Progression in a Manjako Community in West Africa

(2010) L.-M. Yindom et al.   JOURNAL OF VIROLOGY

Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village

(2010) Maarten van der Loeff et al.   Retrovirology

Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease - indication of an evolving epidemic in West Africa

(2010) Joakim Esbjörnsson et al.   Retrovirology

Comparison of viro-immunological marker changes between HIV-1 and HIV-2-infected patients in France

(2009) Julia Drylewicz et al.   AIDS

Differences in proviral DNA load between HIV-1- and HIV-2-infected patients

(2009) Marie Gueudin et al.   AIDS

Changes in prevalence and incidence of HIV-1, HIV-2 and dual infections in urban areas of Bissau, Guinea-Bissau: is HIV-2 disappearing?

(2009) Zacarias J da Silva et al.   AIDS

Prevalence and incidence of HIV-1 and HIV-2 before, during and after a civil war in an occupational cohort in Guinea-Bissau, West Africa

(2009) Fredrik Månsson et al.   AIDS

Studies on toll-like receptor stimuli responsiveness in HIV-1 and HIV-2 infections

(2009) Salma Nowroozalizadeh et al.   CYTOKINE

Direct Relationship between Virus Load and Systemic Immune Activation in HIV‐2 Infection

(2009) Aleksandra Leligdowicz et al.   JOURNAL OF INFECTIOUS DISEASES

Polyfunctional T cell responses are a hallmark of HIV-2 infection

(2008) Melody G. Duvall et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gag-Specific CD4+ T-Cell Frequency Is Inversely Correlated with Proviral Load and Directly Correlated with Immune Activation in Infection with Human Immunodeficiency Virus Type 2 (HIV-2) but Not HIV-1

(2008) R. B. Foxall et al.   JOURNAL OF VIROLOGY

HIV-2: the forgotten AIDS virus

(2008) Thushan I. de Silva et al.   TRENDS IN MICROBIOLOGY